Matches in SemOpenAlex for { <https://semopenalex.org/work/W2900356118> ?p ?o ?g. }
- W2900356118 startingPage "465302" @default.
- W2900356118 abstract "7-Transmembrane-Helix (7TMH) proteins cannot be grouped under a monolithic fold or superfold. A parallel structure-based analysis of pseudo-symmetric membrane domains around that magic number of 7 transmembrane helices, reveals a possible intragenic duplication pattern in their construction. A number of distinct 6/7/8-TMH proteins are examined: MFS, SWEET, PnuC, TRIC, FocA, Aquaporin, and GPCRs, which show evidence of a duplication pattern of a 3 or 4 Transmembrane Helix (3/4-TMH) protodomain, the unifying theme in all membrane proteins examined in this study. Our analysis leads to guiding principles of protodomain assembly and to envision the role of conformational plasticity in fold formation and functional divergence. It also provides a structural and mechanistic framework for the evolutionary deconstruction and reconstruction of current pseudo-symmetrical transmembrane helical (TMH) proteins. In particular, the transmembrane (TM) sequences of intracellular and extracellular facing halves reflect the co-evolution of these protodomains within 6/7/8-TMH pseudo-symmetric domains under functional and structural constraints, especially in the case of G protein coupled receptors (GPCRs). The sequence/structure analysis of different 6/7/8-TMH superfamilies provides a unifying theme of their evolutionary process involving the intragenic duplication of protodomains with varying degrees of sequence and functional divergence under structural constraints." @default.
- W2900356118 created "2018-11-16" @default.
- W2900356118 creator A5069454106 @default.
- W2900356118 creator A5076400708 @default.
- W2900356118 creator A5081431544 @default.
- W2900356118 date "2018-11-08" @default.
- W2900356118 modified "2023-09-22" @default.
- W2900356118 title "Pseudo-Symmetry and Conformational Plasticity in 7 Transmembrane Helix (7TMH) Proteins: Intragenic Duplication and Assembly of 3TMH or 4TMH Protodomains with Evolutionary Balance of Structural Constraints and Functional Divergence" @default.
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