FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2900382890> ?p ?o ?g. }

• W2900382890 endingPage "1681" @default.
• W2900382890 startingPage "1674" @default.
• W2900382890 abstract "Background: Recent intervention studies have suggested that selenium (Se) is an effective treatment for autoimmune thyroiditis (AIT). However, the exact effect of Se on AIT is unclear as well as the mechanism of action. The aim of the present study was to explore the effect of Se on thyroid peroxidase antibody (TPOAb) titers in patients with AIT and to analyze the potential impact of the genetic background on the effect of Se supplementation. Methods: This was a randomized, placebo-controlled, double-blind trial. Three hundred and sixty-four patients with elevated TPOAb (>300 IU/mL) were recruited and randomized to receive Se yeast 200 μg/day supplementation or placebo. Urinary iodine concentration, serum thyrotropin, free thyroxine, TPOAb, Se, malondialdehyde, and serum glutathione peroxidase activity were measured at baseline and follow-up. Ninety-six patients were genotyped for single nucleotide polymorphism r25191G/A in the selenoprotein P (SEPP1/SELENOP) gene. Results: The median urinary iodine concentration was 182 μg/L. Serum Se increased significantly (p < 0.001) after Se treatment. TPOAb titer decreased by 10.0% at 3 months and by 10.7% at 6 months after Se supplementation, while there was a moderate increase in TPOAb titers over the follow-up period in patients receiving placebo. Glutathione peroxidase activity significantly increased (p < 0.001), and malondialdehyde significantly decreased (p < 0.001) after 6 months of Se supplementation. TPOAb titers decreased to variable extents in patients with different genotypes of single nucleotide polymorphism r25191G/A after Se supplementation. Serum TPOAb titers in patients with the AA genotype showed a more significant decrease (by 46.2%) than those with the GA and GG genotypes (by 14.5 and 9.8% respectively) at 3 months of Se supplementation (p = 0.070). Conclusions: Se supplementation significantly reduced TPOAb titers in patients with AIT, and there may be an important genetic component influencing interindividual differences in the decrease in TPOAb titers." @default.
• W2900382890 created "2018-11-16" @default.
• W2900382890 creator A5002287326 @default.
• W2900382890 creator A5010607811 @default.
• W2900382890 creator A5010842655 @default.
• W2900382890 creator A5012799196 @default.
• W2900382890 creator A5015225860 @default.
• W2900382890 creator A5019685555 @default.
• W2900382890 creator A5021257748 @default.
• W2900382890 creator A5032794423 @default.
• W2900382890 creator A5033020983 @default.
• W2900382890 creator A5043874453 @default.
• W2900382890 creator A5045522488 @default.
• W2900382890 creator A5051992470 @default.
• W2900382890 creator A5055675142 @default.
• W2900382890 creator A5077293572 @default.
• W2900382890 creator A5084762460 @default.
• W2900382890 creator A5085140875 @default.
• W2900382890 date "2018-12-01" @default.
• W2900382890 modified "2023-10-03" @default.
• W2900382890 title "Decreased Thyroid Peroxidase Antibody Titer in Response to Selenium Supplementation in Autoimmune Thyroiditis and the Influence of a Selenoprotein P Gene Polymorphism: A Prospective, Multicenter Study in China" @default.
• W2900382890 cites W1964038112 @default.
• W2900382890 cites W1983261536 @default.
• W2900382890 cites W1993076014 @default.
• W2900382890 cites W2006170482 @default.
• W2900382890 cites W2008090659 @default.
• W2900382890 cites W2013131201 @default.
• W2900382890 cites W2026059149 @default.
• W2900382890 cites W2026844201 @default.
• W2900382890 cites W2046098121 @default.
• W2900382890 cites W2051457681 @default.
• W2900382890 cites W2052475191 @default.
• W2900382890 cites W2060844202 @default.
• W2900382890 cites W2114420258 @default.
• W2900382890 cites W2114517714 @default.
• W2900382890 cites W2118611619 @default.
• W2900382890 cites W2121694556 @default.
• W2900382890 cites W2133855383 @default.
• W2900382890 cites W2134410122 @default.
• W2900382890 cites W2135834945 @default.
• W2900382890 cites W2144579285 @default.
• W2900382890 cites W2144587279 @default.
• W2900382890 cites W2161982303 @default.
• W2900382890 cites W2162212157 @default.
• W2900382890 cites W2163839210 @default.
• W2900382890 cites W2168365695 @default.
• W2900382890 cites W2168433858 @default.
• W2900382890 cites W2207775534 @default.
• W2900382890 cites W2527602205 @default.
• W2900382890 cites W2556562919 @default.
• W2900382890 doi "https://doi.org/10.1089/thy.2017.0230" @default.
• W2900382890 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30398407" @default.
• W2900382890 hasPublicationYear "2018" @default.
• W2900382890 type Work @default.
• W2900382890 sameAs 2900382890 @default.
• W2900382890 citedByCount "20" @default.
• W2900382890 countsByYear W29003828902019 @default.
• W2900382890 countsByYear W29003828902020 @default.
• W2900382890 countsByYear W29003828902021 @default.
• W2900382890 countsByYear W29003828902022 @default.
• W2900382890 countsByYear W29003828902023 @default.
• W2900382890 crossrefType "journal-article" @default.
• W2900382890 hasAuthorship W2900382890A5002287326 @default.
• W2900382890 hasAuthorship W2900382890A5010607811 @default.
• W2900382890 hasAuthorship W2900382890A5010842655 @default.
• W2900382890 hasAuthorship W2900382890A5012799196 @default.
• W2900382890 hasAuthorship W2900382890A5015225860 @default.
• W2900382890 hasAuthorship W2900382890A5019685555 @default.
• W2900382890 hasAuthorship W2900382890A5021257748 @default.
• W2900382890 hasAuthorship W2900382890A5032794423 @default.
• W2900382890 hasAuthorship W2900382890A5033020983 @default.
• W2900382890 hasAuthorship W2900382890A5043874453 @default.
• W2900382890 hasAuthorship W2900382890A5045522488 @default.
• W2900382890 hasAuthorship W2900382890A5051992470 @default.
• W2900382890 hasAuthorship W2900382890A5055675142 @default.
• W2900382890 hasAuthorship W2900382890A5077293572 @default.
• W2900382890 hasAuthorship W2900382890A5084762460 @default.
• W2900382890 hasAuthorship W2900382890A5085140875 @default.
• W2900382890 hasConcept C126322002 @default.
• W2900382890 hasConcept C134018914 @default.
• W2900382890 hasConcept C142724271 @default.
• W2900382890 hasConcept C180650514 @default.
• W2900382890 hasConcept C204787440 @default.
• W2900382890 hasConcept C27081682 @default.
• W2900382890 hasConcept C2776151105 @default.
• W2900382890 hasConcept C2776841403 @default.
• W2900382890 hasConcept C2778401633 @default.
• W2900382890 hasConcept C2778696486 @default.
• W2900382890 hasConcept C2778760513 @default.
• W2900382890 hasConcept C2778979269 @default.
• W2900382890 hasConcept C526584372 @default.
• W2900382890 hasConcept C71924100 @default.
• W2900382890 hasConcept C90924648 @default.
• W2900382890 hasConceptScore W2900382890C126322002 @default.
• W2900382890 hasConceptScore W2900382890C134018914 @default.
• W2900382890 hasConceptScore W2900382890C142724271 @default.
• W2900382890 hasConceptScore W2900382890C180650514 @default.
• W2900382890 hasConceptScore W2900382890C204787440 @default.

• next