FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2900397998> ?p ?o ?g. }

• W2900397998 endingPage "1537" @default.
• W2900397998 startingPage "1537" @default.
• W2900397998 abstract "Introduction : Breast cancer is one the most common life-threatening diseases in women. Most breast cancer-related deaths are not due to cancer at the primary site but due to metastasis, a process in which cancer cells spread from the primary site to distant sites such as the lung, bone and brain. The molecular mechanisms underlying breast cancer metastasis are poorly understood. Recent studies have shown that angiopoietin-like proteins, particularly angiopoietin like protein 4 (ANGPTL4), play a crucial role in the modulation of breast cancer metastasis. ANGPTL4, also known as fasting-induced adipose factor (FIAF), is a circulating protein, highly expressed in the liver, adipose tissue and placenta; it plays a role in adipogenesis, angiogenesis, carcinogenesis and metastasis. Recently it has been shown that transforming growth factor #946;1 (TGF#946;1) induces ANGPTL4 expression, which leads to lung metastasis of breast cancer through disruption of the endothelial barrier. Methods : The expression of ANGPTL4 in human normal and breast cancer tissue as well as in normal and breast cancer cell lines was studied by RT-PCR. The expression was also monitored in human normal and colon cancer tissue, and in normal and colon cancer cell lines. Furthermore, the regulation of ANGPTL4 expression in breast cancer cell lines by various growth factors and their receptors, cytokines, and inhibitors of several signaling pathways was investigated. The transcriptional regulation of the gene by potential trans-activators was studied in the human metastatic breast cancer cell line MDA-MB231 by a reporter assay using a 2.2 kb human ANGPTL4 promoter fragment, and luciferase (pGL3-Luc) and GFP (pU3RII-pEGFP) as the reporters. Results : The levels of ANGPTL4 mRNA were higher in human breast cancer and in breast cancer cell lines, and in human colon cancer and colon cancer cell lines. TGF#946;1 and IL-8 induced ANGPTL4 expression in metastatic breast cancer cells. Furthermore, DNA methyltransferases (DNMTs), particularly DNMT1 and DNMT3b, were involved in the regulation ANGPTL4 expression. Functional inactivation of these DNMTs, either by deletion of the genes by homologous recombination or by using pharmacological agents, decreased the expression of ANGPTL4. Treatment of MDA-MB231 cells with Lovastatin, an inhibitor of HMG-CoA reductase, down-regulated ANGPTL4 expression in this cell line. In addition, functional expression of oncogenic Ras, C/EBP#946;, c-Myc and constitutively active Stat3 trans-activated ANGPTL4 promoter in metastatic breast cancer cells. Conclusions : These studies describe the molecular processes involved in the regulation of ANGPTL4 expression in breast cancer. In addition, these studies show that DNA methylation inhibitors and the lipid-lowering drug Lovastatin may have therapeutic potential in the treatment of breast cancer metastasis due to their ability to inhibit the expression of ANGPTL4. Citation Information: In: Proc Am Assoc Cancer Res; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR; 2009. Abstract nr 1537." @default.
• W2900397998 created "2018-11-16" @default.
• W2900397998 creator A5016876329 @default.
• W2900397998 creator A5073081372 @default.
• W2900397998 creator A5088440923 @default.
• W2900397998 creator A5091451352 @default.
• W2900397998 date "2009-05-01" @default.
• W2900397998 modified "2023-09-28" @default.
• W2900397998 title "Abstract #1537: Regulation of angiopoietin-like protein 4 (ANGPTL4) expression in breast cancer and breast cancer cell lines" @default.
• W2900397998 hasPublicationYear "2009" @default.
• W2900397998 type Work @default.
• W2900397998 sameAs 2900397998 @default.
• W2900397998 citedByCount "0" @default.
• W2900397998 crossrefType "journal-article" @default.
• W2900397998 hasAuthorship W2900397998A5016876329 @default.
• W2900397998 hasAuthorship W2900397998A5073081372 @default.
• W2900397998 hasAuthorship W2900397998A5088440923 @default.
• W2900397998 hasAuthorship W2900397998A5091451352 @default.
• W2900397998 hasConcept C104317684 @default.
• W2900397998 hasConcept C111683008 @default.
• W2900397998 hasConcept C118646709 @default.
• W2900397998 hasConcept C121608353 @default.
• W2900397998 hasConcept C126322002 @default.
• W2900397998 hasConcept C2775930923 @default.
• W2900397998 hasConcept C2779013556 @default.
• W2900397998 hasConcept C2780394083 @default.
• W2900397998 hasConcept C502942594 @default.
• W2900397998 hasConcept C530470458 @default.
• W2900397998 hasConcept C55493867 @default.
• W2900397998 hasConcept C555283112 @default.
• W2900397998 hasConcept C71924100 @default.
• W2900397998 hasConcept C77305985 @default.
• W2900397998 hasConcept C86803240 @default.
• W2900397998 hasConcept C96232424 @default.
• W2900397998 hasConceptScore W2900397998C104317684 @default.
• W2900397998 hasConceptScore W2900397998C111683008 @default.
• W2900397998 hasConceptScore W2900397998C118646709 @default.
• W2900397998 hasConceptScore W2900397998C121608353 @default.
• W2900397998 hasConceptScore W2900397998C126322002 @default.
• W2900397998 hasConceptScore W2900397998C2775930923 @default.
• W2900397998 hasConceptScore W2900397998C2779013556 @default.
• W2900397998 hasConceptScore W2900397998C2780394083 @default.
• W2900397998 hasConceptScore W2900397998C502942594 @default.
• W2900397998 hasConceptScore W2900397998C530470458 @default.
• W2900397998 hasConceptScore W2900397998C55493867 @default.
• W2900397998 hasConceptScore W2900397998C555283112 @default.
• W2900397998 hasConceptScore W2900397998C71924100 @default.
• W2900397998 hasConceptScore W2900397998C77305985 @default.
• W2900397998 hasConceptScore W2900397998C86803240 @default.
• W2900397998 hasConceptScore W2900397998C96232424 @default.
• W2900397998 hasLocation W29003979981 @default.
• W2900397998 hasOpenAccess W2900397998 @default.
• W2900397998 hasPrimaryLocation W29003979981 @default.
• W2900397998 hasRelatedWork W1939696168 @default.
• W2900397998 hasRelatedWork W1998733024 @default.
• W2900397998 hasRelatedWork W2008438358 @default.
• W2900397998 hasRelatedWork W2034986953 @default.
• W2900397998 hasRelatedWork W2122431346 @default.
• W2900397998 hasRelatedWork W2145753519 @default.
• W2900397998 hasRelatedWork W2151584857 @default.
• W2900397998 hasRelatedWork W2177693051 @default.
• W2900397998 hasRelatedWork W2595718592 @default.
• W2900397998 hasRelatedWork W2759624873 @default.
• W2900397998 hasRelatedWork W2760415653 @default.
• W2900397998 hasRelatedWork W2772817713 @default.
• W2900397998 hasRelatedWork W2890983267 @default.
• W2900397998 hasRelatedWork W2894165877 @default.
• W2900397998 hasRelatedWork W2921335270 @default.
• W2900397998 hasRelatedWork W2994717720 @default.
• W2900397998 hasRelatedWork W3042190230 @default.
• W2900397998 hasRelatedWork W3093438112 @default.
• W2900397998 hasRelatedWork W3094014166 @default.
• W2900397998 hasRelatedWork W3195830701 @default.
• W2900397998 hasVolume "69" @default.
• W2900397998 isParatext "false" @default.
• W2900397998 isRetracted "false" @default.
• W2900397998 magId "2900397998" @default.
• W2900397998 workType "article" @default.