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• W2900437112 startingPage "3610" @default.
• W2900437112 abstract "Sleep is ancient and fulfills higher brain functions as well as basic vital processes. Little is known about how sleep emerged in evolution and what essential functions it was selected for. Here, we investigated sleep in Caenorhabditis elegans across developmental stages and physiological conditions to find out when and how sleep in a simple animal becomes essential for survival. We found that sleep in worms occurs during most stages and physiological conditions and is typically induced by the sleep-active RIS neuron. Food quality and availability determine sleep amount. Extended starvation, which induces developmental arrest in larvae, presents a major sleep trigger. Conserved nutrient-sensing regulators of longevity and developmental arrest, AMP-activated kinase and FoxO, act in parallel to induce sleep during extended food deprivation. These metabolic factors can act in multiple tissues to signal starvation to RIS. Although sleep does not appear to be essential for a normal adult lifespan, it is crucial for survival of starvation-induced developmental arrest in larvae. Rather than merely saving energy for later use, sleep counteracts the progression of aging phenotypes, perhaps by allocating resources. Thus, sleep presents a protective anti-aging program that is induced by nutrient-sensing longevity pathways to survive starvation-induced developmental arrest. All organisms are threatened with the possibility of experienced famine in their life, which suggests that the molecular coupling of starvation, development, aging, and sleep was selected for early in the evolution of nervous systems and may be conserved in other species, including humans." @default.
• W2900437112 created "2018-11-16" @default.
• W2900437112 creator A5036023533 @default.
• W2900437112 creator A5061682758 @default.
• W2900437112 creator A5070270589 @default.
• W2900437112 creator A5077048649 @default.
• W2900437112 date "2018-11-01" @default.
• W2900437112 modified "2023-09-29" @default.
• W2900437112 title "Sleep Counteracts Aging Phenotypes to Survive Starvation-Induced Developmental Arrest in C. elegans" @default.
• W2900437112 cites W1486595217 @default.
• W2900437112 cites W1501366749 @default.
• W2900437112 cites W1647075334 @default.
• W2900437112 cites W1726094883 @default.
• W2900437112 cites W1911220294 @default.
• W2900437112 cites W1944127002 @default.
• W2900437112 cites W1966145280 @default.
• W2900437112 cites W1969730990 @default.
• W2900437112 cites W1970489875 @default.
• W2900437112 cites W1976095017 @default.
• W2900437112 cites W1976416661 @default.
• W2900437112 cites W1977139215 @default.
• W2900437112 cites W1985294550 @default.
• W2900437112 cites W1986006829 @default.
• W2900437112 cites W1987240473 @default.
• W2900437112 cites W1990211095 @default.
• W2900437112 cites W1992241459 @default.
• W2900437112 cites W1993183165 @default.
• W2900437112 cites W2002293846 @default.
• W2900437112 cites W2007979086 @default.
• W2900437112 cites W2009286795 @default.
• W2900437112 cites W2009558990 @default.
• W2900437112 cites W2011580879 @default.
• W2900437112 cites W2013927030 @default.
• W2900437112 cites W2017246643 @default.
• W2900437112 cites W2018272303 @default.
• W2900437112 cites W2022508149 @default.
• W2900437112 cites W2024515932 @default.
• W2900437112 cites W2028786309 @default.
• W2900437112 cites W2030907978 @default.
• W2900437112 cites W2034734284 @default.
• W2900437112 cites W2038439610 @default.
• W2900437112 cites W2047495081 @default.
• W2900437112 cites W2052446412 @default.
• W2900437112 cites W2054233487 @default.
• W2900437112 cites W2055581281 @default.
• W2900437112 cites W2058484936 @default.
• W2900437112 cites W2059712176 @default.
• W2900437112 cites W2060891261 @default.
• W2900437112 cites W2066210642 @default.
• W2900437112 cites W2066660409 @default.
• W2900437112 cites W2067251833 @default.
• W2900437112 cites W2072681733 @default.
• W2900437112 cites W2074343841 @default.
• W2900437112 cites W2076327464 @default.
• W2900437112 cites W2078588026 @default.
• W2900437112 cites W2087085892 @default.
• W2900437112 cites W2087758126 @default.
• W2900437112 cites W2089145020 @default.
• W2900437112 cites W2090648368 @default.
• W2900437112 cites W2094686403 @default.
• W2900437112 cites W2100365580 @default.
• W2900437112 cites W2101455204 @default.
• W2900437112 cites W2116717495 @default.
• W2900437112 cites W2123138830 @default.
• W2900437112 cites W2123674030 @default.
• W2900437112 cites W2128679613 @default.
• W2900437112 cites W2128797181 @default.
• W2900437112 cites W2132350109 @default.
• W2900437112 cites W2144498949 @default.
• W2900437112 cites W2148418653 @default.
• W2900437112 cites W2154492025 @default.
• W2900437112 cites W2155557838 @default.
• W2900437112 cites W2160615487 @default.
• W2900437112 cites W2163988516 @default.
• W2900437112 cites W2165277324 @default.
• W2900437112 cites W2166015640 @default.
• W2900437112 cites W2166222890 @default.
• W2900437112 cites W2169940731 @default.
• W2900437112 cites W2170979056 @default.
• W2900437112 cites W2204439106 @default.
• W2900437112 cites W2269759225 @default.
• W2900437112 cites W2298484317 @default.
• W2900437112 cites W2308155718 @default.
• W2900437112 cites W2318671960 @default.
• W2900437112 cites W2346631670 @default.
• W2900437112 cites W2417661282 @default.
• W2900437112 cites W2426703678 @default.
• W2900437112 cites W2481995903 @default.
• W2900437112 cites W2523694756 @default.
• W2900437112 cites W2534346109 @default.
• W2900437112 cites W2537691135 @default.
• W2900437112 cites W2564232696 @default.
• W2900437112 cites W2591215085 @default.
• W2900437112 cites W2606022362 @default.
• W2900437112 cites W2616414475 @default.
• W2900437112 cites W2655812336 @default.
• W2900437112 cites W2738520358 @default.
• W2900437112 cites W2745000121 @default.

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