FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2900452912> ?p ?o ?g. }

• W2900452912 endingPage "63" @default.
• W2900452912 startingPage "57" @default.
• W2900452912 abstract "A reliable and accessible biomarker for nonfunctioning pancreatic neuroendocrine tumors (NF-PanNET) is currently unavailable. Chromogranin A (CgA) represents the best-described neuroendocrine biomarker, but its accuracy is low. Vasostatin-1 (VS-1), a fragment derived from the cleavage of CgA, was recently investigated and found to be more accurate as tumor biomarker in a cohort of patients affected by mainly metastatic small intestinal NET. Patients submitted to surgery for sporadic localized NF-PanNET at San Raffaele Hospital were included. Preoperative plasma samples were prospectively collected. Circulating levels of total-CgA and VS-1 were retrospectively investigated by sandwich Enzyme-Linked ImmunoSorbent Assays. Overall, 50 patients were included. VS-1 value (P=0.0001) was the only preoperatively retrievable factor independently associated with NF-PanNET size. No significant correlation between CgA and tumor diameter was found (P = 0.057). A VS-1 value of 0.39 nM was identified as the optimal VS-1 cut-off accurately associated with NF-PanNET larger than 4 cm. Patients with VS-1 > 0.39 nM had a significantly higher frequency of microvascular invasion (P = 0.005) and nodal metastasis (P = 0.027). Median VS-1 plasma level was significantly higher in the presence of microvascular invasion (P = 0.001) and nodal metastasis (P = 0.012). PPI assumption significantly increased total-CgA levels, but not those of VS-1 (P = 0.111). In localized, non-metastatic NF-PanNET, VS-1 is strongly associated to tumor dimension and its plasma levels are significantly higher in the presence of microvascular invasion and nodal metastases; moreover, VS-1 value is not affected by the PPI use." @default.
• W2900452912 created "2018-11-29" @default.
• W2900452912 creator A5001378606 @default.
• W2900452912 creator A5011972071 @default.
• W2900452912 creator A5016560689 @default.
• W2900452912 creator A5045664787 @default.
• W2900452912 creator A5057238914 @default.
• W2900452912 creator A5057380925 @default.
• W2900452912 creator A5063976959 @default.
• W2900452912 date "2019-01-01" @default.
• W2900452912 modified "2023-10-18" @default.
• W2900452912 title "Association between preoperative Vasostatin-1 and pathological features of aggressiveness in localized nonfunctioning pancreatic neuroendocrine tumors (NF-PanNET)" @default.
• W2900452912 cites W1963249638 @default.
• W2900452912 cites W1982249319 @default.
• W2900452912 cites W1998521425 @default.
• W2900452912 cites W2002962269 @default.
• W2900452912 cites W2011205419 @default.
• W2900452912 cites W2026668428 @default.
• W2900452912 cites W2028414515 @default.
• W2900452912 cites W2028774131 @default.
• W2900452912 cites W2038756754 @default.
• W2900452912 cites W2043740725 @default.
• W2900452912 cites W2049243354 @default.
• W2900452912 cites W2061071330 @default.
• W2900452912 cites W2063178653 @default.
• W2900452912 cites W2073558711 @default.
• W2900452912 cites W2080523209 @default.
• W2900452912 cites W2092955619 @default.
• W2900452912 cites W2110016520 @default.
• W2900452912 cites W2110254924 @default.
• W2900452912 cites W2117017066 @default.
• W2900452912 cites W2119014166 @default.
• W2900452912 cites W2156051970 @default.
• W2900452912 cites W2167257250 @default.
• W2900452912 cites W2341351795 @default.
• W2900452912 cites W2570825390 @default.
• W2900452912 cites W2584166571 @default.
• W2900452912 cites W2592896510 @default.
• W2900452912 cites W2608160487 @default.
• W2900452912 cites W2765107149 @default.
• W2900452912 cites W2792155627 @default.
• W2900452912 cites W2799762506 @default.
• W2900452912 cites W2800171779 @default.
• W2900452912 cites W3020992444 @default.
• W2900452912 doi "https://doi.org/10.1016/j.pan.2018.11.005" @default.
• W2900452912 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30470614" @default.
• W2900452912 hasPublicationYear "2019" @default.
• W2900452912 type Work @default.
• W2900452912 sameAs 2900452912 @default.
• W2900452912 citedByCount "5" @default.
• W2900452912 countsByYear W29004529122020 @default.
• W2900452912 countsByYear W29004529122021 @default.
• W2900452912 countsByYear W29004529122022 @default.
• W2900452912 crossrefType "journal-article" @default.
• W2900452912 hasAuthorship W2900452912A5001378606 @default.
• W2900452912 hasAuthorship W2900452912A5011972071 @default.
• W2900452912 hasAuthorship W2900452912A5016560689 @default.
• W2900452912 hasAuthorship W2900452912A5045664787 @default.
• W2900452912 hasAuthorship W2900452912A5057238914 @default.
• W2900452912 hasAuthorship W2900452912A5057380925 @default.
• W2900452912 hasAuthorship W2900452912A5063976959 @default.
• W2900452912 hasConcept C121608353 @default.
• W2900452912 hasConcept C126322002 @default.
• W2900452912 hasConcept C142724271 @default.
• W2900452912 hasConcept C143998085 @default.
• W2900452912 hasConcept C204232928 @default.
• W2900452912 hasConcept C207886595 @default.
• W2900452912 hasConcept C2777209535 @default.
• W2900452912 hasConcept C2778165163 @default.
• W2900452912 hasConcept C2779013556 @default.
• W2900452912 hasConcept C2779066768 @default.
• W2900452912 hasConcept C2781197716 @default.
• W2900452912 hasConcept C55493867 @default.
• W2900452912 hasConcept C71924100 @default.
• W2900452912 hasConcept C77231918 @default.
• W2900452912 hasConcept C86803240 @default.
• W2900452912 hasConcept C90924648 @default.
• W2900452912 hasConceptScore W2900452912C121608353 @default.
• W2900452912 hasConceptScore W2900452912C126322002 @default.
• W2900452912 hasConceptScore W2900452912C142724271 @default.
• W2900452912 hasConceptScore W2900452912C143998085 @default.
• W2900452912 hasConceptScore W2900452912C204232928 @default.
• W2900452912 hasConceptScore W2900452912C207886595 @default.
• W2900452912 hasConceptScore W2900452912C2777209535 @default.
• W2900452912 hasConceptScore W2900452912C2778165163 @default.
• W2900452912 hasConceptScore W2900452912C2779013556 @default.
• W2900452912 hasConceptScore W2900452912C2779066768 @default.
• W2900452912 hasConceptScore W2900452912C2781197716 @default.
• W2900452912 hasConceptScore W2900452912C55493867 @default.
• W2900452912 hasConceptScore W2900452912C71924100 @default.
• W2900452912 hasConceptScore W2900452912C77231918 @default.
• W2900452912 hasConceptScore W2900452912C86803240 @default.
• W2900452912 hasConceptScore W2900452912C90924648 @default.
• W2900452912 hasIssue "1" @default.
• W2900452912 hasLocation W29004529121 @default.
• W2900452912 hasLocation W29004529122 @default.
• W2900452912 hasOpenAccess W2900452912 @default.
• W2900452912 hasPrimaryLocation W29004529121 @default.

• next