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• W2900461036 endingPage "3543" @default.
• W2900461036 startingPage "3533" @default.
• W2900461036 abstract "Our previous study reported that stemofoline (STF) exhibited a synergistic effect with chemotherapeutic drugs inhuman multidrug-resistant (MDR) leukemic cells (K526/Adr) by inhibiting the function of P-glycoprotein, which is amembrane transporter that is overexpressed in several types of MDR cancers. This study further investigated the effects ofa combination treatment of STF and doxorubicin (DOX) in vitro and in vivo. The combination treatment of 50 mg/kg ofSTF strongly enhanced the anti-tumor activity of DOX in SCID-beige mice bearing K562/Adr xenografts withoutadditional toxicity when compared to the single treatment groups. Additionally, an examination of the proliferationmarkers (Ki67) and the apoptotic marker (TUNEL) in tumor tissues in each group revealed that the combinationtherapy significantly reduced Ki67 positive cells and increased apoptotic cells. From the in vitro experiments we alsofound that this combination treatment dramatically induced G1 and G2M arrest in K562/Adr when compared to a singletreatment of DOX. STF treatment alone did not show any cytotoxic effect to the cells. These results suggest that theaccumulation of DOX enhanced by STF was sufficient to induce cell cycle arrest in K562/Adr. These findings supportour previous in vitro data and indicate the possibility of developing STF as an adjuvant therapy in cancer treatments." @default.
• W2900461036 created "2018-11-29" @default.
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• W2900461036 date "2018-12-01" @default.
• W2900461036 modified "2023-10-10" @default.
• W2900461036 title "A Pharmacological Strategy Using Stemofoline for more Efficacious Chemotherapeutic Treatments Against Human Multidrug Resistant Leukemic Cells" @default.
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• W2900461036 doi "https://doi.org/10.31557/apjcp.2018.19.12.3533" @default.
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