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- W2900463072 abstract "Air pollutants generate reactive oxygen species on lung surfaces. Here we report how hydroxyl radicals (·OH) injected on the surface of water react with SP-B1–25, a 25-residue polypeptide surrogate of human lung surfactant protein B. Our experiments consist of intersecting microjets of aqueous SP-B1–25 solutions with O3/O2/H2O/N2(g) gas streams that are photolyzed into ·OH(g) in situ by 266 nm laser nanosecond pulses. Surface-sensitive mass spectrometry enables us to monitor the prompt (<10 μs) and simultaneous formation of primary On-containing products/intermediates (n≤5) triggered by the reaction of ·OH with interfacial SP-B1–25. We found that O-atoms from both O3 and ·OH are incorporated into the reactive cysteine Cys8 and Cys11 and tryptophan Trp9 components of the hydrophobic N-terminus of SP-B1–25 that lies at the topmost layers of the air–liquid interface. Remarkably, these processes are initiated by ·OH additions rather than by H-atom abstractions from S–H, C–H, or N–H groups. By increasing the hydrophilicity of the N-terminus region of SP-B1–25, these transformations will impair its role as a surfactant." @default.
- W2900463072 created "2018-11-29" @default.
- W2900463072 creator A5068302586 @default.
- W2900463072 creator A5071788870 @default.
- W2900463072 date "2018-11-21" @default.
- W2900463072 modified "2023-09-23" @default.
- W2900463072 title "OH-Radical Oxidation of Lung Surfactant Protein B on Aqueous Surfaces" @default.
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- W2900463072 doi "https://doi.org/10.5702/massspectrometry.s0077" @default.
- W2900463072 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6245955" @default.
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- W2900463072 hasPublicationYear "2018" @default.
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