Matches in SemOpenAlex for { <https://semopenalex.org/work/W2900470510> ?p ?o ?g. }
- W2900470510 endingPage "128" @default.
- W2900470510 startingPage "118" @default.
- W2900470510 abstract "Previously, a series of aurones bearing amine and carbamate functionalities was synthesized and evaluated for their cholinesterase inhibitory activity and drug-like attributes. In the present study, these aurones were evaluated for their multi-targeting properties in two Alzheimer’s disease (AD)-related activities namely, monoamine oxidase (MAO) and amyloid-beta (Aβ) inhibition. Evaluation of the aurones for MAO inhibitory activity disclosed several potent selective inhibitors of MAO-B, particularly those with 6-methoxyl group attached at ring A. Of the different amine moieties attached as side chains, pyrrolidine-bearing aurones were prominent as represented by 2-2, the most potent inhibitor. Evaluation on the Aβ aggregation inhibition identified 4-3 as the best inhibitor with a percentage inhibition comparable to that of a known Aβ inhibitor curcumin. Examination on the neuroprotective ability of the more drug-like aurone 4-3 in two Caenorhabditis elegans neurodegeneration models showed 4-3 to protect the nematodes against both Aβ- and 6-hydroxydopamine-induced toxicities. These new activities further support 4-3 as a promising lead to develop the aurones as potential multipotent agents for neurodegenerative diseases." @default.
- W2900470510 created "2018-11-29" @default.
- W2900470510 creator A5015418988 @default.
- W2900470510 creator A5052717945 @default.
- W2900470510 creator A5070718944 @default.
- W2900470510 creator A5083468164 @default.
- W2900470510 date "2019-02-01" @default.
- W2900470510 modified "2023-09-27" @default.
- W2900470510 title "Multi-targeting aurones with monoamine oxidase and amyloid-beta inhibitory activities: Structure-activity relationship and translating multi-potency to neuroprotection" @default.
- W2900470510 cites W149565960 @default.
- W2900470510 cites W1504674761 @default.
- W2900470510 cites W1572452765 @default.
- W2900470510 cites W1733175660 @default.
- W2900470510 cites W1940331911 @default.
- W2900470510 cites W1965718249 @default.
- W2900470510 cites W1967223669 @default.
- W2900470510 cites W1971729859 @default.
- W2900470510 cites W1978522315 @default.
- W2900470510 cites W1994067502 @default.
- W2900470510 cites W2000225222 @default.
- W2900470510 cites W2001405361 @default.
- W2900470510 cites W2003428681 @default.
- W2900470510 cites W2010426046 @default.
- W2900470510 cites W2013176372 @default.
- W2900470510 cites W2017606063 @default.
- W2900470510 cites W2023018514 @default.
- W2900470510 cites W2031231661 @default.
- W2900470510 cites W2038557175 @default.
- W2900470510 cites W2038942391 @default.
- W2900470510 cites W2046880577 @default.
- W2900470510 cites W2049805159 @default.
- W2900470510 cites W2062930327 @default.
- W2900470510 cites W2064407760 @default.
- W2900470510 cites W2065245388 @default.
- W2900470510 cites W2070520328 @default.
- W2900470510 cites W2079313884 @default.
- W2900470510 cites W2080225612 @default.
- W2900470510 cites W2080375658 @default.
- W2900470510 cites W2084972185 @default.
- W2900470510 cites W2089835787 @default.
- W2900470510 cites W2092545090 @default.
- W2900470510 cites W2094994507 @default.
- W2900470510 cites W2096410114 @default.
- W2900470510 cites W2114896498 @default.
- W2900470510 cites W2120992224 @default.
- W2900470510 cites W2131819352 @default.
- W2900470510 cites W2171727894 @default.
- W2900470510 cites W2554987097 @default.
- W2900470510 doi "https://doi.org/10.1016/j.biopha.2018.11.054" @default.
- W2900470510 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30466001" @default.
- W2900470510 hasPublicationYear "2019" @default.
- W2900470510 type Work @default.
- W2900470510 sameAs 2900470510 @default.
- W2900470510 citedByCount "9" @default.
- W2900470510 countsByYear W29004705102020 @default.
- W2900470510 countsByYear W29004705102021 @default.
- W2900470510 countsByYear W29004705102022 @default.
- W2900470510 countsByYear W29004705102023 @default.
- W2900470510 crossrefType "journal-article" @default.
- W2900470510 hasAuthorship W2900470510A5015418988 @default.
- W2900470510 hasAuthorship W2900470510A5052717945 @default.
- W2900470510 hasAuthorship W2900470510A5070718944 @default.
- W2900470510 hasAuthorship W2900470510A5083468164 @default.
- W2900470510 hasBestOaLocation W29004705101 @default.
- W2900470510 hasConcept C181199279 @default.
- W2900470510 hasConcept C185592680 @default.
- W2900470510 hasConcept C25498285 @default.
- W2900470510 hasConcept C2776024655 @default.
- W2900470510 hasConcept C2778250585 @default.
- W2900470510 hasConcept C31896038 @default.
- W2900470510 hasConcept C39398028 @default.
- W2900470510 hasConcept C55493867 @default.
- W2900470510 hasConcept C71240020 @default.
- W2900470510 hasConcept C71924100 @default.
- W2900470510 hasConcept C98274493 @default.
- W2900470510 hasConceptScore W2900470510C181199279 @default.
- W2900470510 hasConceptScore W2900470510C185592680 @default.
- W2900470510 hasConceptScore W2900470510C25498285 @default.
- W2900470510 hasConceptScore W2900470510C2776024655 @default.
- W2900470510 hasConceptScore W2900470510C2778250585 @default.
- W2900470510 hasConceptScore W2900470510C31896038 @default.
- W2900470510 hasConceptScore W2900470510C39398028 @default.
- W2900470510 hasConceptScore W2900470510C55493867 @default.
- W2900470510 hasConceptScore W2900470510C71240020 @default.
- W2900470510 hasConceptScore W2900470510C71924100 @default.
- W2900470510 hasConceptScore W2900470510C98274493 @default.
- W2900470510 hasFunder F4320321709 @default.
- W2900470510 hasFunder F4320322757 @default.
- W2900470510 hasFunder F4320329006 @default.
- W2900470510 hasLocation W29004705101 @default.
- W2900470510 hasLocation W29004705102 @default.
- W2900470510 hasLocation W29004705103 @default.
- W2900470510 hasOpenAccess W2900470510 @default.
- W2900470510 hasPrimaryLocation W29004705101 @default.
- W2900470510 hasRelatedWork W1978339404 @default.
- W2900470510 hasRelatedWork W2015987533 @default.
- W2900470510 hasRelatedWork W2037168299 @default.
- W2900470510 hasRelatedWork W2091558615 @default.