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• W2900484414 abstract "Introduction Identifying specific IgE sensitization in patients with chronic spontaneous urticaria (CSU) is not recommended by current guidelines. The objective of this review was to evaluate markers of TH2 inflammation in all patients with CSU undergoing treatment with omalizumab. Methods Systematic literature reviews were conducted using the PubMed, Medline and Google Scholar electronic databases for English studies published in peer-reviewed journals between 2010 to 2018 to identify studies of CSU where markers of TH2 inflammation were determined. Results A total of 18 studies were identified, involving 1892 patients. Thirteen studies found the mean total IgE levels in the CSU population to be elevated at 211.5 IU/ml (normal 133-570.6 IU/mL, and an absolute range of values of 0-5600 IU/mL. On average, 39% of the CSU population had IgG autoantibody directed to the high-affinity receptor for the Fc region of IgE (FcεRIa) compared to 2.9% in control groups. Patients with CSU were 5.4 times more likely to have IgG autoantibody to FcεRIa (95% CI 2.8-10.6) than the controls (p < 0.00001). Mean total blood eosinophil % was elevated at 5.5% (n = 279) (normal ≤ 4%), despite many patients being on systemic corticosteroids. Conclusions Elevated levels of total IgE, blood eosinophil counts, and FcεRIa-specific autoantibodies in the CSU population may indicate the importance of TH2 inflammation in the pathogenesis of CSU. Perhaps the role of specific IgE sensitization in CSU should be revisited. Identifying specific IgE sensitization in patients with chronic spontaneous urticaria (CSU) is not recommended by current guidelines. The objective of this review was to evaluate markers of TH2 inflammation in all patients with CSU undergoing treatment with omalizumab. Systematic literature reviews were conducted using the PubMed, Medline and Google Scholar electronic databases for English studies published in peer-reviewed journals between 2010 to 2018 to identify studies of CSU where markers of TH2 inflammation were determined. A total of 18 studies were identified, involving 1892 patients. Thirteen studies found the mean total IgE levels in the CSU population to be elevated at 211.5 IU/ml (normal 133-570.6 IU/mL, and an absolute range of values of 0-5600 IU/mL. On average, 39% of the CSU population had IgG autoantibody directed to the high-affinity receptor for the Fc region of IgE (FcεRIa) compared to 2.9% in control groups. Patients with CSU were 5.4 times more likely to have IgG autoantibody to FcεRIa (95% CI 2.8-10.6) than the controls (p < 0.00001). Mean total blood eosinophil % was elevated at 5.5% (n = 279) (normal ≤ 4%), despite many patients being on systemic corticosteroids. Elevated levels of total IgE, blood eosinophil counts, and FcεRIa-specific autoantibodies in the CSU population may indicate the importance of TH2 inflammation in the pathogenesis of CSU. Perhaps the role of specific IgE sensitization in CSU should be revisited." @default.
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• W2900484414 date "2018-11-01" @default.
• W2900484414 modified "2023-09-27" @default.
• W2900484414 title "MARKERS OF TH2 INFLAMMATION IN PATIENTS WITH CHRONIC SPONTANEOUS URTICARIA: A SYSTEMATIC LITERATURE REVIEW" @default.
• W2900484414 doi "https://doi.org/10.1016/j.anai.2018.09.117" @default.
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