Matches in SemOpenAlex for { <https://semopenalex.org/work/W2900501672> ?p ?o ?g. }
- W2900501672 abstract "Abstract Sialic acid (Sia) residues on cell surface are critical for myriad cellular events such as immunity and inflammation. We herein reported the use of abiotic Sia to raise the thresholds of inflammatory cell responses. Identified from a panel of structurally diversified Sia analogs via a cell inflammation assay, Sia-2, with N -butyryl moiety at C-5, markedly lowered LPS-stimulated NF-κB activity in macrophages. Further analysis shows that Sia-2 attenuates phosphorylation of IκB and Erk1/2/p38/JNK, critical for NF-κB signaling and MAPK signaling, and lowers gene transcription of proinflammatory interleukin-6. These results support the use of abiotic Sia as promising agents to modulate cell surface Sia-pertinent cell signaling." @default.
- W2900501672 created "2018-11-29" @default.
- W2900501672 creator A5002578267 @default.
- W2900501672 creator A5032188592 @default.
- W2900501672 creator A5039982353 @default.
- W2900501672 creator A5050152196 @default.
- W2900501672 creator A5065735840 @default.
- W2900501672 creator A5067011111 @default.
- W2900501672 creator A5069188763 @default.
- W2900501672 date "2018-11-23" @default.
- W2900501672 modified "2023-10-10" @default.
- W2900501672 title "On the use of abiotic sialic acids to attenuate cell inflammation" @default.
- W2900501672 cites W1482074571 @default.
- W2900501672 cites W1512741418 @default.
- W2900501672 cites W1967297513 @default.
- W2900501672 cites W1970087902 @default.
- W2900501672 cites W1971907885 @default.
- W2900501672 cites W1974677375 @default.
- W2900501672 cites W1974938963 @default.
- W2900501672 cites W1985537536 @default.
- W2900501672 cites W1989569828 @default.
- W2900501672 cites W2004465286 @default.
- W2900501672 cites W2027170262 @default.
- W2900501672 cites W2029249295 @default.
- W2900501672 cites W2033877739 @default.
- W2900501672 cites W2034949980 @default.
- W2900501672 cites W2037767282 @default.
- W2900501672 cites W2046056065 @default.
- W2900501672 cites W2056445309 @default.
- W2900501672 cites W2059260998 @default.
- W2900501672 cites W2062289724 @default.
- W2900501672 cites W2062923968 @default.
- W2900501672 cites W2066307140 @default.
- W2900501672 cites W2073870582 @default.
- W2900501672 cites W2085043812 @default.
- W2900501672 cites W2086525709 @default.
- W2900501672 cites W2087027040 @default.
- W2900501672 cites W2101363646 @default.
- W2900501672 cites W2101710014 @default.
- W2900501672 cites W2103007380 @default.
- W2900501672 cites W2107495112 @default.
- W2900501672 cites W2112785873 @default.
- W2900501672 cites W2115806827 @default.
- W2900501672 cites W2120121992 @default.
- W2900501672 cites W2120533079 @default.
- W2900501672 cites W2123063574 @default.
- W2900501672 cites W2127674627 @default.
- W2900501672 cites W2128088040 @default.
- W2900501672 cites W2129106319 @default.
- W2900501672 cites W2129617028 @default.
- W2900501672 cites W2143007555 @default.
- W2900501672 cites W2143301135 @default.
- W2900501672 cites W2147143140 @default.
- W2900501672 cites W2148119611 @default.
- W2900501672 cites W2155755315 @default.
- W2900501672 cites W2158924104 @default.
- W2900501672 cites W2163283852 @default.
- W2900501672 cites W2167500896 @default.
- W2900501672 cites W2168470451 @default.
- W2900501672 cites W2169135213 @default.
- W2900501672 cites W2281466216 @default.
- W2900501672 cites W2339311912 @default.
- W2900501672 cites W2620769476 @default.
- W2900501672 cites W2736346397 @default.
- W2900501672 doi "https://doi.org/10.1038/s41598-018-35477-2" @default.
- W2900501672 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6251910" @default.
- W2900501672 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30470771" @default.
- W2900501672 hasPublicationYear "2018" @default.
- W2900501672 type Work @default.
- W2900501672 sameAs 2900501672 @default.
- W2900501672 citedByCount "3" @default.
- W2900501672 countsByYear W29005016722020 @default.
- W2900501672 countsByYear W29005016722021 @default.
- W2900501672 crossrefType "journal-article" @default.
- W2900501672 hasAuthorship W2900501672A5002578267 @default.
- W2900501672 hasAuthorship W2900501672A5032188592 @default.
- W2900501672 hasAuthorship W2900501672A5039982353 @default.
- W2900501672 hasAuthorship W2900501672A5050152196 @default.
- W2900501672 hasAuthorship W2900501672A5065735840 @default.
- W2900501672 hasAuthorship W2900501672A5067011111 @default.
- W2900501672 hasAuthorship W2900501672A5069188763 @default.
- W2900501672 hasBestOaLocation W29005016721 @default.
- W2900501672 hasConcept C104317684 @default.
- W2900501672 hasConcept C132215390 @default.
- W2900501672 hasConcept C1491633281 @default.
- W2900501672 hasConcept C150555746 @default.
- W2900501672 hasConcept C151730666 @default.
- W2900501672 hasConcept C164027704 @default.
- W2900501672 hasConcept C185592680 @default.
- W2900501672 hasConcept C203014093 @default.
- W2900501672 hasConcept C2776914184 @default.
- W2900501672 hasConcept C2780115458 @default.
- W2900501672 hasConcept C51551487 @default.
- W2900501672 hasConcept C55493867 @default.
- W2900501672 hasConcept C57074206 @default.
- W2900501672 hasConcept C62478195 @default.
- W2900501672 hasConcept C86339819 @default.
- W2900501672 hasConcept C86803240 @default.
- W2900501672 hasConcept C95444343 @default.
- W2900501672 hasConceptScore W2900501672C104317684 @default.