Matches in SemOpenAlex for { <https://semopenalex.org/work/W2900505005> ?p ?o ?g. }
- W2900505005 endingPage "461" @default.
- W2900505005 startingPage "449" @default.
- W2900505005 abstract "Abstract For many cancer types, the immune system plays an essential role in their development and growth. Based on these rather novel insights, immunotherapeutic strategies have been developed. In the past decade, immune checkpoint blockade has demonstrated a major breakthrough in cancer treatment and has currently been approved for the treatment of multiple tumor types. Adoptive cell therapy (ACT) with tumor-infiltrating lymphocytes (TIL) or gene-modified T cells expressing novel T cell receptors (TCR) or chimeric antigen receptors (CAR) is another strategy to modify the immune system to recognize tumor cells and thus carry out an anti-tumor effector function. These treatments have shown promising results in various tumor types, and multiple clinical trials are being conducted worldwide to further optimize this treatment modality. Most successful results were obtained in hematological malignancies with the use of CD19-directed CAR T cell therapy and already led to the commercial approval by the FDA. This review provides an overview of the developments in ACT, the associated toxicity, and the future potential of ACT in cancer treatment." @default.
- W2900505005 created "2018-11-29" @default.
- W2900505005 creator A5017136846 @default.
- W2900505005 creator A5033241663 @default.
- W2900505005 creator A5061367251 @default.
- W2900505005 date "2018-11-23" @default.
- W2900505005 modified "2023-10-14" @default.
- W2900505005 title "Adoptive cellular therapies: the current landscape" @default.
- W2900505005 cites W1624657716 @default.
- W2900505005 cites W1703091204 @default.
- W2900505005 cites W1950572133 @default.
- W2900505005 cites W1965504034 @default.
- W2900505005 cites W1967517831 @default.
- W2900505005 cites W1968592882 @default.
- W2900505005 cites W1970087181 @default.
- W2900505005 cites W1972077866 @default.
- W2900505005 cites W1976158962 @default.
- W2900505005 cites W1979818745 @default.
- W2900505005 cites W1983056774 @default.
- W2900505005 cites W1983143892 @default.
- W2900505005 cites W1990005899 @default.
- W2900505005 cites W1990602451 @default.
- W2900505005 cites W1993858544 @default.
- W2900505005 cites W1994993231 @default.
- W2900505005 cites W2003624697 @default.
- W2900505005 cites W2005354199 @default.
- W2900505005 cites W2007753570 @default.
- W2900505005 cites W2010303814 @default.
- W2900505005 cites W2010607826 @default.
- W2900505005 cites W2012108097 @default.
- W2900505005 cites W2013798321 @default.
- W2900505005 cites W2016671320 @default.
- W2900505005 cites W2021472146 @default.
- W2900505005 cites W2027863358 @default.
- W2900505005 cites W2028460943 @default.
- W2900505005 cites W2036063900 @default.
- W2900505005 cites W2037993285 @default.
- W2900505005 cites W2041655295 @default.
- W2900505005 cites W2044442352 @default.
- W2900505005 cites W2046562334 @default.
- W2900505005 cites W2047205338 @default.
- W2900505005 cites W2050302632 @default.
- W2900505005 cites W2051549641 @default.
- W2900505005 cites W2058899594 @default.
- W2900505005 cites W2064510700 @default.
- W2900505005 cites W2064932721 @default.
- W2900505005 cites W2070748533 @default.
- W2900505005 cites W2075574520 @default.
- W2900505005 cites W2076335749 @default.
- W2900505005 cites W2078197336 @default.
- W2900505005 cites W2083431965 @default.
- W2900505005 cites W2085935150 @default.
- W2900505005 cites W2087091972 @default.
- W2900505005 cites W2089828715 @default.
- W2900505005 cites W2094652659 @default.
- W2900505005 cites W2097173066 @default.
- W2900505005 cites W2099570622 @default.
- W2900505005 cites W2099736081 @default.
- W2900505005 cites W2104597364 @default.
- W2900505005 cites W2105400883 @default.
- W2900505005 cites W2106511557 @default.
- W2900505005 cites W2113802879 @default.
- W2900505005 cites W2118796952 @default.
- W2900505005 cites W2124373740 @default.
- W2900505005 cites W2124446900 @default.
- W2900505005 cites W2127734125 @default.
- W2900505005 cites W2129702476 @default.
- W2900505005 cites W2130011407 @default.
- W2900505005 cites W2130338247 @default.
- W2900505005 cites W2131473264 @default.
- W2900505005 cites W2132923173 @default.
- W2900505005 cites W2132948331 @default.
- W2900505005 cites W2137088550 @default.
- W2900505005 cites W2141410122 @default.
- W2900505005 cites W2142257845 @default.
- W2900505005 cites W2143626441 @default.
- W2900505005 cites W2144491853 @default.
- W2900505005 cites W2148523692 @default.
- W2900505005 cites W2149209349 @default.
- W2900505005 cites W2149699468 @default.
- W2900505005 cites W2153520524 @default.
- W2900505005 cites W2153590293 @default.
- W2900505005 cites W2153712501 @default.
- W2900505005 cites W2155026493 @default.
- W2900505005 cites W2162184613 @default.
- W2900505005 cites W2166226087 @default.
- W2900505005 cites W2169579205 @default.
- W2900505005 cites W2201278844 @default.
- W2900505005 cites W2214791309 @default.
- W2900505005 cites W2221432805 @default.
- W2900505005 cites W2226616534 @default.
- W2900505005 cites W2292597058 @default.
- W2900505005 cites W2293521247 @default.
- W2900505005 cites W2309691699 @default.
- W2900505005 cites W2395676613 @default.
- W2900505005 cites W2482999389 @default.
- W2900505005 cites W2504729294 @default.
- W2900505005 cites W2509364267 @default.