Matches in SemOpenAlex for { <https://semopenalex.org/work/W2900514529> ?p ?o ?g. }
- W2900514529 abstract "Anaplastic lymphoma kinase (ALK) is a tyrosine kinase receptor that is a clinical target of major interest in cancer. Mutations and rearrangements in ALK trigger the activation of the encoded receptor and its downstream signaling pathways. ALK mutations have been identified in both familial and sporadic neuroblastoma cases as well as in 30 to 40% of relapses, which makes ALK a bona fide target in neuroblastoma therapy. Tyrosine kinase inhibitors (TKIs) that target ALK are currently in clinical use for the treatment of patients with ALK-positive non-small cell lung cancer. However, monotherapy with the ALK inhibitor crizotinib has been less encouraging in neuroblastoma patients with ALK alterations, raising the question of whether combinatorial therapy would be more effective. In this study, we established both phosphoproteomic and gene expression profiles of ALK activity in neuroblastoma cells exposed to first- and third-generation ALK TKIs, to identify the underlying molecular mechanisms and identify relevant biomarkers, signaling networks, and new therapeutic targets. This analysis has unveiled various important leads for novel combinatorial treatment strategies for patients with neuroblastoma and an increased understanding of ALK signaling involved in this disease." @default.
- W2900514529 created "2018-11-29" @default.
- W2900514529 creator A5002721999 @default.
- W2900514529 creator A5007977575 @default.
- W2900514529 creator A5025880133 @default.
- W2900514529 creator A5032564835 @default.
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- W2900514529 creator A5044229149 @default.
- W2900514529 creator A5049469623 @default.
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- W2900514529 creator A5074444663 @default.
- W2900514529 creator A5082957078 @default.
- W2900514529 creator A5091191169 @default.
- W2900514529 date "2018-11-20" @default.
- W2900514529 modified "2023-09-30" @default.
- W2900514529 title "Phosphoproteome and gene expression profiling of ALK inhibition in neuroblastoma cell lines reveals conserved oncogenic pathways" @default.
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