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• W2900514986 abstract "Antibiotic residue, as emerging pollution resulting from antibiotic abuse, poses a serious threat on ecosystem and human health. Conventional methods for antibiotic detection, e.g., liquid/gas chromatography, are based on complicated instruments and time-consuming; therefore, efforts have been made to realize in situ and real-time monitoring of antibiotics. Here, a miniaturized and integratable electronic antibiotic sensor based on field-effect transistor (FET) is reported. The reduced graphene oxide (rGO) nanosheet is used as the channel material and the aptamer RNA for tobramycin is modified onto rGO as the probe. A novel sensor design with 6-mercapto-1-hexanol (MCH)/1-pyrenebutanol (PBA) blocking layer (BL) for structure optimization is applied to enhance the sensor reliability and specificity. This rGO/aptamer/BL sensor shows an ultra-sensitivity to tobramycin with a lower detection limit of 0.3 nM and a quick response within 5 s, as well as a high specificity over other antibiotics such as kanamycin, streptomycin, ciprofloxacin, and tetracycline. The sensing mechanism based on the deformation of the charged aptamer probe is proposed via an in-depth analysis of the interactions between aptamer, tobramycin and rGO. In addition, sensing test performed under controlled microfluidic flow conditions demonstrates a great potential of the sensors in practical applications." @default.
• W2900514986 created "2018-11-29" @default.
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• W2900514986 date "2019-02-01" @default.
• W2900514986 modified "2023-10-13" @default.
• W2900514986 title "Ultratrace antibiotic sensing using aptamer/graphene-based field-effect transistors" @default.
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• W2900514986 doi "https://doi.org/10.1016/j.bios.2018.11.034" @default.
• W2900514986 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30530212" @default.
• W2900514986 hasPublicationYear "2019" @default.
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