FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2900519175> ?p ?o ?g. }

• W2900519175 endingPage "15" @default.
• W2900519175 startingPage "1" @default.
• W2900519175 abstract "The relationship between varicocele and fertility has always been a matter of debate because of the absence of predictive clinical indicators or molecular markers able to define the severity of this disease. Even though accumulated evidence demonstrated that the endocannabinoid system (ECS) plays a central role in male reproductive biology, particularly in the testicular compartment, to date no data point to a role for ECS in the etiopathogenesis of varicocele. Therefore, the present research has been designed to investigate the relationship between testicular ECS gene expression and fertility, using a validated animal model of experimental varicocele (VAR), taking advantage of traditional statistical approaches and artificial neural network (ANN). Experimental induction of VAR led to a clear reduction of spermatogenesis in left testes ranging from a mild (Johnsen score 7: 21%) to a severe (Johnsen score 4: 58%) damage of the germinal epithelium. However, the mean number of new-borns recorded after two sequential matings was quite variable and independent of the Johnsen score. While the gene expression of biosynthetic and degrading enzymes of AEA (NAPE-PLD and FAAH, respectively) and of 2-AG (DAGL α and MAGL, respectively), as well as their binding cannabinoid receptors (CB 1 and CB 2 ), did not change between testes and among groups, a significant downregulation of vanilloid (TRPV1) expression was recorded in left testes of VAR rats and positively correlated with animal fertility. Interestingly, an ANN trained by inserting the left and right testicular ECS gene expression profiles (inputs) was able to predict varicocele impact on male fertility in terms of mean number of new-borns delivered (outputs), with a very high accuracy (average prediction error of 1%). The present study provides unprecedented information on testicular ECS gene expression patterns during varicocele, by developing a freely available predictive ANN model that may open new perspectives in the diagnosis of varicocele-associated infertility." @default.
• W2900519175 created "2018-11-29" @default.
• W2900519175 creator A5007088211 @default.
• W2900519175 creator A5015367318 @default.
• W2900519175 creator A5019752163 @default.
• W2900519175 creator A5040520015 @default.
• W2900519175 creator A5046675917 @default.
• W2900519175 creator A5060591081 @default.
• W2900519175 creator A5069326941 @default.
• W2900519175 creator A5082080602 @default.
• W2900519175 creator A5084489352 @default.
• W2900519175 creator A5086707955 @default.
• W2900519175 creator A5091332504 @default.
• W2900519175 date "2018-11-13" @default.
• W2900519175 modified "2023-10-05" @default.
• W2900519175 title "Artificial Neural Network to Predict Varicocele Impact on Male Fertility through Testicular Endocannabinoid Gene Expression Profiles" @default.
• W2900519175 cites W149046334 @default.
• W2900519175 cites W1498436455 @default.
• W2900519175 cites W1553029954 @default.
• W2900519175 cites W1555818161 @default.
• W2900519175 cites W1727290854 @default.
• W2900519175 cites W1821539668 @default.
• W2900519175 cites W1864669634 @default.
• W2900519175 cites W1923202901 @default.
• W2900519175 cites W1978936699 @default.
• W2900519175 cites W1979938143 @default.
• W2900519175 cites W1985325184 @default.
• W2900519175 cites W1987717082 @default.
• W2900519175 cites W1990714593 @default.
• W2900519175 cites W1993516781 @default.
• W2900519175 cites W2002535987 @default.
• W2900519175 cites W2005694755 @default.
• W2900519175 cites W2021138861 @default.
• W2900519175 cites W2031212289 @default.
• W2900519175 cites W2032631457 @default.
• W2900519175 cites W2033553393 @default.
• W2900519175 cites W2052372081 @default.
• W2900519175 cites W2059168493 @default.
• W2900519175 cites W2060277249 @default.
• W2900519175 cites W2062557443 @default.
• W2900519175 cites W2062734801 @default.
• W2900519175 cites W2062767227 @default.
• W2900519175 cites W2067864509 @default.
• W2900519175 cites W2076228635 @default.
• W2900519175 cites W2076975188 @default.
• W2900519175 cites W2087296025 @default.
• W2900519175 cites W2090843150 @default.
• W2900519175 cites W2093315658 @default.
• W2900519175 cites W2094051883 @default.
• W2900519175 cites W2096195476 @default.
• W2900519175 cites W2102154241 @default.
• W2900519175 cites W2102188803 @default.
• W2900519175 cites W2107277218 @default.
• W2900519175 cites W2108474339 @default.
• W2900519175 cites W2110082320 @default.
• W2900519175 cites W2111361033 @default.
• W2900519175 cites W2112827290 @default.
• W2900519175 cites W2113207118 @default.
• W2900519175 cites W2114343065 @default.
• W2900519175 cites W2115755671 @default.
• W2900519175 cites W2116605247 @default.
• W2900519175 cites W2116649023 @default.
• W2900519175 cites W2119780457 @default.
• W2900519175 cites W2130600650 @default.
• W2900519175 cites W2132160195 @default.
• W2900519175 cites W2137724899 @default.
• W2900519175 cites W2141014386 @default.
• W2900519175 cites W2141293077 @default.
• W2900519175 cites W2144073503 @default.
• W2900519175 cites W2146866311 @default.
• W2900519175 cites W2162516508 @default.
• W2900519175 cites W2170953670 @default.
• W2900519175 cites W2192080449 @default.
• W2900519175 cites W2215602123 @default.
• W2900519175 cites W2222970347 @default.
• W2900519175 cites W2240280269 @default.
• W2900519175 cites W2262814078 @default.
• W2900519175 cites W2295264566 @default.
• W2900519175 cites W2319814963 @default.
• W2900519175 cites W2398190948 @default.
• W2900519175 cites W2417596961 @default.
• W2900519175 cites W2470085322 @default.
• W2900519175 cites W2592216350 @default.
• W2900519175 cites W2616618306 @default.
• W2900519175 cites W2725628753 @default.
• W2900519175 cites W2750919948 @default.
• W2900519175 cites W2752241260 @default.
• W2900519175 cites W2917574652 @default.
• W2900519175 cites W3021347101 @default.
• W2900519175 cites W37591796 @default.
• W2900519175 cites W37887123 @default.
• W2900519175 cites W4210959510 @default.
• W2900519175 cites W4233542142 @default.
• W2900519175 cites W4298228160 @default.
• W2900519175 cites W4302339906 @default.
• W2900519175 doi "https://doi.org/10.1155/2018/3591086" @default.
• W2900519175 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6258097" @default.
• W2900519175 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30539009" @default.

• next