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- W2900526197 endingPage "1002" @default.
- W2900526197 startingPage "981" @default.
- W2900526197 abstract "ABSTRACT The calcium release‐activated calcium (CRAC) channel, composed of ORAI and stromal interaction molecules (STIM), represents a prototypical example of store‐operated calcium entry in mammals. The ORAI‐STIM signaling occurs at membrane contact sites formed by close appositions between the endoplasmic reticulum (ER) and the plasma membrane. ORAI1 is a four‐pass transmembrane protein that forms a highly calcium‐selective ion channel in the plasma membrane. STIM1 is an ER‐resident, a single‐pass transmembrane protein that serves as a calcium sensor within the ER lumen and a potent activator of ORAI1 calcium channels. The intricate interplay between ORAI and STIM controls calcium entry into cells to regulate a myriad of physiological processes. We highlight herein the current knowledge on the structure‐function relationship of CRAC channel, with a focus on key structural elements that mediate STIM1 conformational switch and the dynamic coupling between STIM1 and ORAI1. Furthermore, we discuss the physiological roles of STIM‐ORAI signaling in various tissues and organs, as well as major pathological conditions arising from loss‐ or gain‐of‐function mutations in human ORAI1 and STIM1. © 2017 American Physiological Society. Compr Physiol 8:981‐1002, 2018." @default.
- W2900526197 created "2018-11-29" @default.
- W2900526197 creator A5003662438 @default.
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- W2900526197 creator A5071602703 @default.
- W2900526197 creator A5073632725 @default.
- W2900526197 date "2018-06-18" @default.
- W2900526197 modified "2023-10-14" @default.
- W2900526197 title "Store‐Operated Calcium Entry Mediated by ORAI and STIM" @default.
- W2900526197 cites W111410485 @default.
- W2900526197 cites W1485297825 @default.
- W2900526197 cites W1495215957 @default.
- W2900526197 cites W1500581977 @default.
- W2900526197 cites W1544230004 @default.
- W2900526197 cites W1546599127 @default.
- W2900526197 cites W1554199623 @default.
- W2900526197 cites W1581327117 @default.
- W2900526197 cites W1593637618 @default.
- W2900526197 cites W1599277155 @default.
- W2900526197 cites W1608909099 @default.
- W2900526197 cites W1761464554 @default.
- W2900526197 cites W1773482870 @default.
- W2900526197 cites W1843230840 @default.
- W2900526197 cites W1856053518 @default.
- W2900526197 cites W1934528477 @default.
- W2900526197 cites W1964205844 @default.
- W2900526197 cites W1965629349 @default.
- W2900526197 cites W1967175288 @default.
- W2900526197 cites W1967218656 @default.
- W2900526197 cites W1967797998 @default.
- W2900526197 cites W1970151239 @default.
- W2900526197 cites W1971529415 @default.
- W2900526197 cites W1972239832 @default.
- W2900526197 cites W1975221601 @default.
- W2900526197 cites W1976015442 @default.
- W2900526197 cites W1976566307 @default.
- W2900526197 cites W1978593035 @default.
- W2900526197 cites W1979573280 @default.
- W2900526197 cites W1981125908 @default.
- W2900526197 cites W1981840225 @default.
- W2900526197 cites W1982522146 @default.
- W2900526197 cites W1982528213 @default.
- W2900526197 cites W1982731106 @default.
- W2900526197 cites W1985592845 @default.
- W2900526197 cites W1985674147 @default.
- W2900526197 cites W1985785210 @default.
- W2900526197 cites W1985924867 @default.
- W2900526197 cites W1985948706 @default.
- W2900526197 cites W1986506306 @default.
- W2900526197 cites W1986531910 @default.
- W2900526197 cites W1988248740 @default.
- W2900526197 cites W1989178712 @default.
- W2900526197 cites W1990548229 @default.
- W2900526197 cites W1992735552 @default.
- W2900526197 cites W1993712825 @default.
- W2900526197 cites W1993781709 @default.
- W2900526197 cites W1995076152 @default.
- W2900526197 cites W1995782709 @default.
- W2900526197 cites W1996047650 @default.
- W2900526197 cites W1996693518 @default.
- W2900526197 cites W1999321414 @default.
- W2900526197 cites W2001917660 @default.
- W2900526197 cites W2004208753 @default.
- W2900526197 cites W2004234324 @default.
- W2900526197 cites W2004779826 @default.
- W2900526197 cites W2004856071 @default.
- W2900526197 cites W2005128153 @default.
- W2900526197 cites W2005700813 @default.
- W2900526197 cites W2006227978 @default.
- W2900526197 cites W2007840462 @default.
- W2900526197 cites W2008613689 @default.
- W2900526197 cites W2009707152 @default.
- W2900526197 cites W2009866298 @default.
- W2900526197 cites W2009968707 @default.
- W2900526197 cites W2010052045 @default.
- W2900526197 cites W2010105936 @default.
- W2900526197 cites W2015080011 @default.
- W2900526197 cites W2015480034 @default.
- W2900526197 cites W2019023589 @default.
- W2900526197 cites W2019141252 @default.
- W2900526197 cites W2019889005 @default.
- W2900526197 cites W2020033048 @default.
- W2900526197 cites W2020708758 @default.
- W2900526197 cites W2023518937 @default.
- W2900526197 cites W2024047363 @default.
- W2900526197 cites W2024183493 @default.
- W2900526197 cites W2025102008 @default.
- W2900526197 cites W2026912177 @default.
- W2900526197 cites W2026937490 @default.
- W2900526197 cites W2027524220 @default.
- W2900526197 cites W2028649950 @default.
- W2900526197 cites W2029301182 @default.
- W2900526197 cites W2031149920 @default.