Matches in SemOpenAlex for { <https://semopenalex.org/work/W2900545582> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2900545582 endingPage "101" @default.
- W2900545582 startingPage "95" @default.
- W2900545582 abstract "Drug-induced liver injury (DILI) is a serious adverse reaction due to flucloxacillin. The pathogenesis is not fully understood. Female sex, age over 60 years, and a longer treatment duration have been suggested to be predisposing factors. Carriers of HLA-B*57:01 have an 80-fold increased risk, but due to the rarity of the reaction, testing of all patients is not cost-effective. We aimed to validate and detect clinical risk factors for flucloxacillin DILI.Clinical characteristics of flucloxacillin-treated patients with (n=50) and without DILI (n=2,330) were compared in a retrospective case control study. Cases were recruited from the Swedish database of spontaneously reported adverse drug reactions. Treated controls were selected from the Swedish Twin Registry. Statistical comparisons were made using chi-squared test and logistic regression. The significance threshold was set to P<0.00357 to correct for multiple comparisons. Reliable variables were tested in a multiple regression model.DILI was associated with female sex, OR 2.79, 95% CI 1.50-5.17, P=0.0011, and with a history of kidney stones, OR 5.51, 95% CI 2.21-13.72, P=0.0003. Cases were younger than controls, OR per increase in years 0.91, 95% CI 0.88-0.94, P<0.0001, probably due to selection bias. No difference in treatment duration was detected, OR 1.03, 95% CI 0.98-1.08, P=0.1790.We established female sex as a risk factor for flucloxacillin-induced DILI, and a history of kidney stones was identified as a potential risk factor. Clinical risk factors for flucloxacillin-induced DILI could be used to indicate whom to test for HLA-B*57:01 before treatment." @default.
- W2900545582 created "2018-11-29" @default.
- W2900545582 creator A5003137589 @default.
- W2900545582 creator A5047914572 @default.
- W2900545582 creator A5053748287 @default.
- W2900545582 creator A5066812926 @default.
- W2900545582 date "2018-11-01" @default.
- W2900545582 modified "2023-10-16" @default.
- W2900545582 title "Clinical factors predicting drug-induced liver injury due to flucloxacillin" @default.
- W2900545582 cites W1559956070 @default.
- W2900545582 cites W1958573926 @default.
- W2900545582 cites W1973293519 @default.
- W2900545582 cites W1976214439 @default.
- W2900545582 cites W1991554738 @default.
- W2900545582 cites W2002493942 @default.
- W2900545582 cites W2003268732 @default.
- W2900545582 cites W2022085508 @default.
- W2900545582 cites W2031364396 @default.
- W2900545582 cites W2032330856 @default.
- W2900545582 cites W2059179441 @default.
- W2900545582 cites W2060470911 @default.
- W2900545582 cites W2061290402 @default.
- W2900545582 cites W2065039457 @default.
- W2900545582 cites W2075352120 @default.
- W2900545582 cites W2079109653 @default.
- W2900545582 cites W2081074064 @default.
- W2900545582 cites W2123590494 @default.
- W2900545582 cites W2139741257 @default.
- W2900545582 cites W2166018731 @default.
- W2900545582 cites W2320830449 @default.
- W2900545582 cites W2499688117 @default.
- W2900545582 cites W2559870928 @default.
- W2900545582 doi "https://doi.org/10.2147/dhps.s178394" @default.
- W2900545582 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6254585" @default.
- W2900545582 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30538582" @default.
- W2900545582 hasPublicationYear "2018" @default.
- W2900545582 type Work @default.
- W2900545582 sameAs 2900545582 @default.
- W2900545582 citedByCount "7" @default.
- W2900545582 countsByYear W29005455822020 @default.
- W2900545582 countsByYear W29005455822021 @default.
- W2900545582 countsByYear W29005455822022 @default.
- W2900545582 countsByYear W29005455822023 @default.
- W2900545582 crossrefType "journal-article" @default.
- W2900545582 hasAuthorship W2900545582A5003137589 @default.
- W2900545582 hasAuthorship W2900545582A5047914572 @default.
- W2900545582 hasAuthorship W2900545582A5053748287 @default.
- W2900545582 hasAuthorship W2900545582A5066812926 @default.
- W2900545582 hasBestOaLocation W29005455821 @default.
- W2900545582 hasConcept C126322002 @default.
- W2900545582 hasConcept C151956035 @default.
- W2900545582 hasConcept C167135981 @default.
- W2900545582 hasConcept C197934379 @default.
- W2900545582 hasConcept C2776637226 @default.
- W2900545582 hasConcept C2778355172 @default.
- W2900545582 hasConcept C2779489039 @default.
- W2900545582 hasConcept C50440223 @default.
- W2900545582 hasConcept C523546767 @default.
- W2900545582 hasConcept C54355233 @default.
- W2900545582 hasConcept C71924100 @default.
- W2900545582 hasConcept C86803240 @default.
- W2900545582 hasConceptScore W2900545582C126322002 @default.
- W2900545582 hasConceptScore W2900545582C151956035 @default.
- W2900545582 hasConceptScore W2900545582C167135981 @default.
- W2900545582 hasConceptScore W2900545582C197934379 @default.
- W2900545582 hasConceptScore W2900545582C2776637226 @default.
- W2900545582 hasConceptScore W2900545582C2778355172 @default.
- W2900545582 hasConceptScore W2900545582C2779489039 @default.
- W2900545582 hasConceptScore W2900545582C50440223 @default.
- W2900545582 hasConceptScore W2900545582C523546767 @default.
- W2900545582 hasConceptScore W2900545582C54355233 @default.
- W2900545582 hasConceptScore W2900545582C71924100 @default.
- W2900545582 hasConceptScore W2900545582C86803240 @default.
- W2900545582 hasLocation W29005455821 @default.
- W2900545582 hasLocation W29005455822 @default.
- W2900545582 hasLocation W29005455823 @default.
- W2900545582 hasLocation W29005455824 @default.
- W2900545582 hasLocation W29005455825 @default.
- W2900545582 hasOpenAccess W2900545582 @default.
- W2900545582 hasPrimaryLocation W29005455821 @default.
- W2900545582 hasRelatedWork W2028371130 @default.
- W2900545582 hasRelatedWork W2105151527 @default.
- W2900545582 hasRelatedWork W2354901326 @default.
- W2900545582 hasRelatedWork W2389709268 @default.
- W2900545582 hasRelatedWork W3009852707 @default.
- W2900545582 hasRelatedWork W3013145321 @default.
- W2900545582 hasRelatedWork W3095141535 @default.
- W2900545582 hasRelatedWork W3208090289 @default.
- W2900545582 hasRelatedWork W3210359220 @default.
- W2900545582 hasRelatedWork W4255376461 @default.
- W2900545582 hasVolume "Volume 10" @default.
- W2900545582 isParatext "false" @default.
- W2900545582 isRetracted "false" @default.
- W2900545582 magId "2900545582" @default.
- W2900545582 workType "article" @default.