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• W2900548468 abstract "Abstract Doxorubicin and paclitaxel, two hydrophobic chemotherapeutic agents, are used in cancer therapies. Presence of hydrophobic patches and a flexible fold could probably make α-Lactalbumin a suitable carrier for hydrophobic drugs. In the present study, a variety of thermodynamic, spectroscopic, computational, and cellular techniques were applied to assess α-lactalbumin potential as a carrier for doxorubicin and paclitaxel. According to isothermal titration calorimetry data, the interaction between α-lactalbumin and doxorubicin or paclitaxel is spontaneous and the K (M −1 ) value for the interaction of α-lactalbumin and paclitaxel is higher than that for doxorubicin. Differential scanning calorimetry and anisotropy results indicated formation of α-lactalbumin complexes with doxorubicin or paclitaxel. Furthermore, molecular docking and dynamic studies revealed that TRPs are not involved in α-Lac’s interaction with Doxorubicin while TRP 60 interacts with paclitaxel. Based on Pace analysis to determine protein thermal stability, doxorubicin and paclitaxel induced higher and lower thermal stability in α-lactalbumin, respectively. Besides, fluorescence lifetime measurements reflected that the interaction between α-lactalbumin with doxorubicin or paclitaxel was of static nature. Therefore, the authors hypothesized that α-lactalbumin could serve as a carrier for doxorubicin and paclitaxel by reducing cytotoxicity and apoptosis which was demonstrated during our in vitro cell studies." @default.
• W2900548468 created "2018-11-29" @default.
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• W2900548468 date "2018-11-26" @default.
• W2900548468 modified "2023-10-16" @default.
• W2900548468 title "A biophysical study on the mechanism of interactions of DOX or PTX with α-lactalbumin as a delivery carrier" @default.
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• W2900548468 doi "https://doi.org/10.1038/s41598-018-35559-1" @default.
• W2900548468 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6255783" @default.
• W2900548468 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30478403" @default.
• W2900548468 hasPublicationYear "2018" @default.
• W2900548468 type Work @default.
• W2900548468 sameAs 2900548468 @default.

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