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• W2900558675 abstract "Abstract Osmotic alterations are associated with several human diseases, including diabetic nephropathy. We have previously shown that high glucose, which is a well‐known osmotic agent, induces significant disruption of the tight junction (TJ)‐mediated tubular barrier of the Madin–Darby canine kidney (MDCK) cell line. In this study, we investigated the effect of acute (24 h) and chronic (72 h) exposure to increased osmolality (with a 14.5 mM mannitol solution) on TJ‐mediated barrier function in MDCK cells. The treatment with mannitol significantly increased the transepithelial electrical resistance (TEER) and accelerated the TEER recovery after Ca 2+ switch assay in comparison with control monolayers. Immunofluorescence and Western blot analyses showed that mannitol treatment induced a significant increase in the tight junctional and cellular content of claudin‐1 (a barrier‐forming claudin) as well as a significant decrease in claudin‐2 (a pore‐forming claudin) junctional and cellular contents. These data suggest that an increased osmolality induces enhancement of the TJ‐mediated barrier of MDCK cells, and that, therefore, the negative effect of high glucose on the epithelial paracellular barrier cannot be attributed to its osmotic actions. In addition, a subtle increase in osmolality may have an impact on kidney function and renal‐related diseases." @default.
• W2900558675 created "2018-11-29" @default.
• W2900558675 creator A5053677891 @default.
• W2900558675 creator A5066994848 @default.
• W2900558675 date "2018-12-27" @default.
• W2900558675 modified "2023-10-01" @default.
• W2900558675 title "Increased osmolality enhances the tight junction-mediated barrier function in a cultured renal epithelial cell line" @default.
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• W2900558675 doi "https://doi.org/10.1002/cbin.11074" @default.
• W2900558675 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30468279" @default.
• W2900558675 hasPublicationYear "2018" @default.
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