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- W2900575438 abstract "A core–shell ensemble of bovine hemoglobin (Hb) and human serum albumin (HSA) is an artificial O2 carrier as a red blood cell substitute. This protein particle is created by covalent wrapping of a carbonyl Hb with HSAs: HbR–HSA3 cluster, where HbR signifies the use of carbonyl Hb (relaxed (R) state conformation) as a starting material. The HbR–HSA3 cluster exhibits high O2 affinity and low cooperativity. Analysis of the quaternary structure of the central HbR in the cluster revealed that its high O2 affinity is attributed to the physically immobile HbR nucleus. Circular dichroism and UV–vis absorption spectroscopy showed that the structure of deoxy HbR core closely resembles the R-state. The crystal structure of Lys-modified carbonyl HbR was superimposed on that of carbonyl Hb. These results imply that chemical modifications of the surface Lys groups and Cys-93(β) of the carbonyl Hb with cross-linking agent interfered in the quaternary structure movement from the R-state to tense (T) state. As expected, coupling of deoxy Hb (T-state) with HSAs yielded HbT–HSA3 cluster having low O2 affinity. The mixing of HbR–HSA3 and HbT–HSA3 clusters conferred a tailor-made formulation of artificial O2 carrier with a desired O2 affinity (P50)." @default.
- W2900575438 created "2018-11-29" @default.
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- W2900575438 date "2018-11-16" @default.
- W2900575438 modified "2023-10-11" @default.
- W2900575438 title "Quaternary Structure Analysis of a Hemoglobin Core in Hemoglobin–Albumin Cluster" @default.
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- W2900575438 doi "https://doi.org/10.1021/acs.jpcb.8b10077" @default.
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