FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2900577994> ?p ?o ?g. }

• W2900577994 endingPage "e0207366" @default.
• W2900577994 startingPage "e0207366" @default.
• W2900577994 abstract "The Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP), a polycationic, amphiphilic and helical neuropeptide, is well known for its neuroprotective actions and cell penetrating properties. In the present study, we evaluated the potent antibacterial property of PACAP38 and related analogs against various bacterial strains. Interestingly, PACAP38 and related analogs can inhibit the growth of various bacteria including Escherichia coli (JM109), Bacillus subtilis (PY79), and the pathogenic Burkholderia cenocepacia (J2315). Investigation of the mechanism of action suggested that a PACAP metabolite, identified as PACAP(9-38), might indeed be responsible for the observed PACAP38 antibacterial action. Surprisingly, PACAP(9-38), which does not induce haemolysis, exhibits an increased specificity toward Burkholderia cenocepacia J2315 compared to other tested bacteria. Finally, the predisposition of PACAP(9-38) to adopt a π-helix conformation rather than an α-helical conformation like PACAP38 could explain this gain in specificity. Overall, this study has revealed a new function for PACAP38 and related derivatives that can be added to its pleiotropic biological activities. This innovative study could therefore pave the way toward the development of new therapeutic agents against multiresistant bacteria, and more specifically the Burkholderia cenocepacia complex." @default.
• W2900577994 created "2018-11-29" @default.
• W2900577994 creator A5006175603 @default.
• W2900577994 creator A5027368726 @default.
• W2900577994 creator A5036058683 @default.
• W2900577994 creator A5038208747 @default.
• W2900577994 creator A5050869331 @default.
• W2900577994 creator A5053724659 @default.
• W2900577994 creator A5072778586 @default.
• W2900577994 creator A5079917358 @default.
• W2900577994 creator A5082617665 @default.
• W2900577994 creator A5086454546 @default.
• W2900577994 date "2018-11-21" @default.
• W2900577994 modified "2023-10-16" @default.
• W2900577994 title "Antibacterial properties of the pituitary adenylate cyclase-activating polypeptide: A new human antimicrobial peptide" @default.
• W2900577994 cites W1888185978 @default.
• W2900577994 cites W1945664147 @default.
• W2900577994 cites W1966078827 @default.
• W2900577994 cites W1977069728 @default.
• W2900577994 cites W1986326641 @default.
• W2900577994 cites W1990733397 @default.
• W2900577994 cites W2008708467 @default.
• W2900577994 cites W2015746473 @default.
• W2900577994 cites W2034297574 @default.
• W2900577994 cites W2042699876 @default.
• W2900577994 cites W2050895876 @default.
• W2900577994 cites W2063746709 @default.
• W2900577994 cites W2066275795 @default.
• W2900577994 cites W2067174909 @default.
• W2900577994 cites W2079182949 @default.
• W2900577994 cites W2081260116 @default.
• W2900577994 cites W2102906662 @default.
• W2900577994 cites W2115622227 @default.
• W2900577994 cites W2127522551 @default.
• W2900577994 cites W2128572087 @default.
• W2900577994 cites W2132460256 @default.
• W2900577994 cites W2134747968 @default.
• W2900577994 cites W2147859611 @default.
• W2900577994 cites W2156979070 @default.
• W2900577994 cites W2169222199 @default.
• W2900577994 cites W2179036997 @default.
• W2900577994 cites W2316913446 @default.
• W2900577994 cites W2321603276 @default.
• W2900577994 cites W2402171825 @default.
• W2900577994 cites W2768173870 @default.
• W2900577994 cites W2800450220 @default.
• W2900577994 doi "https://doi.org/10.1371/journal.pone.0207366" @default.
• W2900577994 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6248945" @default.
• W2900577994 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30462698" @default.
• W2900577994 hasPublicationYear "2018" @default.
• W2900577994 type Work @default.
• W2900577994 sameAs 2900577994 @default.
• W2900577994 citedByCount "5" @default.
• W2900577994 countsByYear W29005779942020 @default.
• W2900577994 countsByYear W29005779942021 @default.
• W2900577994 countsByYear W29005779942023 @default.
• W2900577994 crossrefType "journal-article" @default.
• W2900577994 hasAuthorship W2900577994A5006175603 @default.
• W2900577994 hasAuthorship W2900577994A5027368726 @default.
• W2900577994 hasAuthorship W2900577994A5036058683 @default.
• W2900577994 hasAuthorship W2900577994A5038208747 @default.
• W2900577994 hasAuthorship W2900577994A5050869331 @default.
• W2900577994 hasAuthorship W2900577994A5053724659 @default.
• W2900577994 hasAuthorship W2900577994A5072778586 @default.
• W2900577994 hasAuthorship W2900577994A5079917358 @default.
• W2900577994 hasAuthorship W2900577994A5082617665 @default.
• W2900577994 hasAuthorship W2900577994A5086454546 @default.
• W2900577994 hasBestOaLocation W29005779941 @default.
• W2900577994 hasConcept C104317684 @default.
• W2900577994 hasConcept C170493617 @default.
• W2900577994 hasConcept C180526460 @default.
• W2900577994 hasConcept C185592680 @default.
• W2900577994 hasConcept C2777272437 @default.
• W2900577994 hasConcept C2777979451 @default.
• W2900577994 hasConcept C2780069284 @default.
• W2900577994 hasConcept C2780104969 @default.
• W2900577994 hasConcept C2780855054 @default.
• W2900577994 hasConcept C4937899 @default.
• W2900577994 hasConcept C523546767 @default.
• W2900577994 hasConcept C540938839 @default.
• W2900577994 hasConcept C54355233 @default.
• W2900577994 hasConcept C547475151 @default.
• W2900577994 hasConcept C55493867 @default.
• W2900577994 hasConcept C86803240 @default.
• W2900577994 hasConcept C89423630 @default.
• W2900577994 hasConceptScore W2900577994C104317684 @default.
• W2900577994 hasConceptScore W2900577994C170493617 @default.
• W2900577994 hasConceptScore W2900577994C180526460 @default.
• W2900577994 hasConceptScore W2900577994C185592680 @default.
• W2900577994 hasConceptScore W2900577994C2777272437 @default.
• W2900577994 hasConceptScore W2900577994C2777979451 @default.
• W2900577994 hasConceptScore W2900577994C2780069284 @default.
• W2900577994 hasConceptScore W2900577994C2780104969 @default.
• W2900577994 hasConceptScore W2900577994C2780855054 @default.
• W2900577994 hasConceptScore W2900577994C4937899 @default.
• W2900577994 hasConceptScore W2900577994C523546767 @default.
• W2900577994 hasConceptScore W2900577994C540938839 @default.
• W2900577994 hasConceptScore W2900577994C54355233 @default.

• next