FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2900599151> ?p ?o ?g. }

• W2900599151 endingPage "345" @default.
• W2900599151 startingPage "336" @default.
• W2900599151 abstract "The SPOUT family of enzymes makes up the second largest of seven structurally distinct groups of methyltransferases and is named after two evolutionarily related RNA methyltransferases, SpoU and TrmD. A deep trefoil knotted domain in the tertiary structures of member enzymes defines the SPOUT family. For many years, formation of a homodimeric quaternary structure was thought to be a strict requirement for all SPOUT enzymes, critical for substrate binding and formation of the active site. However, recent structural characterization of two SPOUT members, Trm10 and Sfm1, revealed that they function as monomers without the requirement of this critical dimerization. This unusual monomeric form implies that these enzymes must exhibit a nontraditional substrate binding mode and active site architecture and may represent a new division in the SPOUT family with distinct properties removed from the dimeric enzymes. Here we discuss the mechanistic features of SPOUT enzymes with an emphasis on the monomeric members and implications of this “novel” monomeric structure on cofactor and substrate binding." @default.
• W2900599151 created "2018-11-29" @default.
• W2900599151 creator A5002863056 @default.
• W2900599151 creator A5022205141 @default.
• W2900599151 date "2018-11-20" @default.
• W2900599151 modified "2023-10-14" @default.
• W2900599151 title "A Family Divided: Distinct Structural and Mechanistic Features of the SpoU-TrmD (SPOUT) Methyltransferase Superfamily" @default.
• W2900599151 cites W1496844582 @default.
• W2900599151 cites W1497068429 @default.
• W2900599151 cites W1499272745 @default.
• W2900599151 cites W1521190384 @default.
• W2900599151 cites W1581165587 @default.
• W2900599151 cites W1620761982 @default.
• W2900599151 cites W1753285579 @default.
• W2900599151 cites W1932734291 @default.
• W2900599151 cites W1963614491 @default.
• W2900599151 cites W1977738109 @default.
• W2900599151 cites W1981791357 @default.
• W2900599151 cites W1985801486 @default.
• W2900599151 cites W1994261442 @default.
• W2900599151 cites W2026004144 @default.
• W2900599151 cites W2027173928 @default.
• W2900599151 cites W2032757954 @default.
• W2900599151 cites W2041730140 @default.
• W2900599151 cites W2044015620 @default.
• W2900599151 cites W2052885644 @default.
• W2900599151 cites W2060344007 @default.
• W2900599151 cites W2064969549 @default.
• W2900599151 cites W2071241692 @default.
• W2900599151 cites W2072871227 @default.
• W2900599151 cites W2074266891 @default.
• W2900599151 cites W2079531680 @default.
• W2900599151 cites W2082388363 @default.
• W2900599151 cites W2097105872 @default.
• W2900599151 cites W2100071542 @default.
• W2900599151 cites W2100205151 @default.
• W2900599151 cites W2102041979 @default.
• W2900599151 cites W2104107140 @default.
• W2900599151 cites W2116709001 @default.
• W2900599151 cites W2117031151 @default.
• W2900599151 cites W2117113235 @default.
• W2900599151 cites W2117889142 @default.
• W2900599151 cites W2117892897 @default.
• W2900599151 cites W2126358181 @default.
• W2900599151 cites W2131064870 @default.
• W2900599151 cites W2132740573 @default.
• W2900599151 cites W2133168873 @default.
• W2900599151 cites W2138463176 @default.
• W2900599151 cites W2139283159 @default.
• W2900599151 cites W2142125112 @default.
• W2900599151 cites W2151771785 @default.
• W2900599151 cites W2153689708 @default.
• W2900599151 cites W2164367666 @default.
• W2900599151 cites W2167611648 @default.
• W2900599151 cites W2168003751 @default.
• W2900599151 cites W2221756059 @default.
• W2900599151 cites W2266719610 @default.
• W2900599151 cites W2516486208 @default.
• W2900599151 cites W2563740023 @default.
• W2900599151 cites W2592607575 @default.
• W2900599151 cites W2606353465 @default.
• W2900599151 cites W2736462848 @default.
• W2900599151 cites W2805591138 @default.
• W2900599151 cites W2806263203 @default.
• W2900599151 doi "https://doi.org/10.1021/acs.biochem.8b01047" @default.
• W2900599151 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6541868" @default.
• W2900599151 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30457841" @default.
• W2900599151 hasPublicationYear "2018" @default.
• W2900599151 type Work @default.
• W2900599151 sameAs 2900599151 @default.
• W2900599151 citedByCount "17" @default.
• W2900599151 countsByYear W29005991512019 @default.
• W2900599151 countsByYear W29005991512020 @default.
• W2900599151 countsByYear W29005991512021 @default.
• W2900599151 countsByYear W29005991512022 @default.
• W2900599151 countsByYear W29005991512023 @default.
• W2900599151 crossrefType "journal-article" @default.
• W2900599151 hasAuthorship W2900599151A5002863056 @default.
• W2900599151 hasAuthorship W2900599151A5022205141 @default.
• W2900599151 hasBestOaLocation W29005991512 @default.
• W2900599151 hasConcept C104292427 @default.
• W2900599151 hasConcept C104317684 @default.
• W2900599151 hasConcept C107824862 @default.
• W2900599151 hasConcept C166940927 @default.
• W2900599151 hasConcept C178790620 @default.
• W2900599151 hasConcept C181199279 @default.
• W2900599151 hasConcept C185592680 @default.
• W2900599151 hasConcept C18903297 @default.
• W2900599151 hasConcept C197957613 @default.
• W2900599151 hasConcept C2777289219 @default.
• W2900599151 hasConcept C33288867 @default.
• W2900599151 hasConcept C41183919 @default.
• W2900599151 hasConcept C521977710 @default.
• W2900599151 hasConcept C552990157 @default.
• W2900599151 hasConcept C55493867 @default.
• W2900599151 hasConcept C71240020 @default.
• W2900599151 hasConcept C7927669 @default.
• W2900599151 hasConcept C86803240 @default.

• next