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• W2900607856 abstract "Cell-to-cell signaling via small molecules is an essential process to coordinate behavior in single species within a community, and also across kingdoms. In this review, we discuss the quorum sensing (QS) systems used by the opportunistic pathogen <i>Pseudomonas aeruginosa</i> to sense bacterial population density and fitness, and regulate virulence, biofilm development, metabolite acquisition, and mammalian host defense. We also focus on the role of <i>N</i>-acylhomoserine lactone-dependent QS signaling in the modulation of innate immune responses connected together via calcium signaling, homeostasis, mitochondrial and cytoskeletal dynamics, and governing transcriptional and proteomic responses of host cells. A future perspective emphasizes the need for multidisciplinary efforts to bring current knowledge of QS into a more detailed understanding of the communication between bacteria and host, as well as into strategies to prevent and treat <i>P. aeruginosa</i> infections and reduce the rate of antibiotic resistance." @default.
• W2900607856 created "2018-11-29" @default.
• W2900607856 creator A5016178530 @default.
• W2900607856 creator A5039434791 @default.
• W2900607856 date "2018-11-14" @default.
• W2900607856 modified "2023-10-15" @default.
• W2900607856 title "Bacteria-Host Crosstalk: Sensing of the Quorum in the Context of <b><i>Pseudomonas aeruginosa</i></b> Infections" @default.
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