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• W2900622102 abstract "The objective of this study was to evaluate the physical properties, cytotoxicity and sealing ability of HealApex _a new premixed calcium-silicate-phosphate-based biosealer_ in comparison with AH-26.Setting time, working time, film thickness, flow and radiopacity evaluation were performed according to ISO 6876 specification. L929 fibroblasts were incubated with the extracts of sealers and cytotoxicity was then evaluated using MTT assay. Thirty intact extracted human premolars were instrumented using step-back technique. The specimens were obturated with gutta-percha and experimental sealers employing lateral condensation technique. Sealing ability of sealers was investigated for up to one month using fluid filtration method. Data were statistically analyzed by t-test and ANOVA.Physical properties of both sealers conformed to ISO specification. AH-26 exhibited significantly higher flow, higher radiopacity and lower film thickness; whereas HealApex showed lower setting time (P<0.05). HealApex represented high cell viability (P<0.05); however, AH-26 demonstrated significantly lower cell viability compared with the negative control group (P<0.05). There was no significant difference in microleakage between the sealers after 1 and 7 days; however, after 30 days, HealApex displayed better sealing ability (P<0.05).In this in vitro study, HealApex revealed acceptable physical properties, biocompatibility and good sealing ability as an endodontic sealer. Obtained results showed the new sealer had acceptable physical properties and good biocompatibility. In short term, the sealing ability of HealApex was comparable with AH-26 whilst in long term, HealApex's sealing ability was better than the epoxy resin-based sealer." @default.
• W2900622102 created "2018-11-29" @default.
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• W2900622102 date "2018-01-01" @default.
• W2900622102 modified "2023-09-23" @default.
• W2900622102 title "Physical Properties, Cytocompatibility and Sealability of HealApex (a Novel Premixed Biosealer)." @default.
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• W2900622102 doi "https://doi.org/10.22037/iej.v13i3.20188" @default.
• W2900622102 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6064026" @default.
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