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• W2900642763 endingPage "125" @default.
• W2900642763 startingPage "116" @default.
• W2900642763 abstract "Prostate Specific Antigen (PSA) is a biomarker employed for detection of prostate cancer. An electrochemical nanobiosensor is designed and fabricated using a molecularly imprinted polymer for the simple and fast PSA detection. The imprinted polymer served as a PSA artificial receptor fabricated by electrochemical polymerization of pyrrole on screen-printed gold electrode in the presence of PSA. PSA was a molecular template for the polymer. The fabricated nanobiosensor was evaluated by differential pulse voltammetry and using K3[Fe(CN)6]/K4[Fe(CN)6] as an electrochemical marker. The factors influencing the performance of the sensor including electropolymerization cycle umbers (to control the thickness of the polymer film) and time of PSA binding were optimized to attain the best sensitivity. The binding affinity of the nanobiosensor surface was examined by the Freundlich isotherm with Freundlich constant and exponent of 0.89 ng mL-1 and 10.93, respectively. The nanobiosensor demonstrated a fast rebinding rate and a high capacity of PSA recognition with detection limit of 2.0 pg mL-1." @default.
• W2900642763 created "2018-11-29" @default.
• W2900642763 creator A5020977060 @default.
• W2900642763 creator A5038028119 @default.
• W2900642763 creator A5044916380 @default.
• W2900642763 date "2019-02-01" @default.
• W2900642763 modified "2023-10-13" @default.
• W2900642763 title "A molecularly imprinted electrochemical nanobiosensor for prostate specific antigen determination" @default.
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• W2900642763 doi "https://doi.org/10.1016/j.ab.2018.11.020" @default.
• W2900642763 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30472220" @default.
• W2900642763 hasPublicationYear "2019" @default.
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