FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2900643023> ?p ?o ?g. }

• W2900643023 endingPage "214" @default.
• W2900643023 startingPage "207" @default.
• W2900643023 abstract "Inducible nitric oxide synthase (iNOS) pathway has been in the limelight since its discovery as a key mediator in the process of liver fibrogenesis. Therefore, the objective of the current study was to elucidate the in vivo molecular mechanism underlying the hepatic preventive relevance of eugenol (EUG) and telmisartan (TEL) through iNOS pathway modulation against carbon tetrachloride (CCl4)-induced hepatic injury.Sixty healthy male albino rats were used in this study. Serum aminotransferases activities and NO levels were assessed. Hepatic malondialdehyde (MDA), total nitrite/nitrate content and reduced glutathione (GSH) concentration were estimated. Liver NF-kB, TNF-α, IL-6 and iNOS proteins expressions were investigated by western blot assay. Histopathological examination was done.CCl4 resulted in damage to centrilobular regions of the liver, elevation of serum aminotransferases, rise in oxidative parameters level, and up-regulation of NF-kB, TNF-α, IL-6 as well as iNOS proteins expressions. Treatment of fibrotic rats with either EUG or TEL significantly alleviated CCl4-induced biochemical, inflammatory and histopathological changes. Moreover, the combined administration of EUG with TEL has an ameliorative effect which is greater than either of them alone.In conclusion, the combination therapy between EUG and TEL is more effective than either drug alone which is attributed to suppression of NO production and iNOS protein expression. The results support that use of EUG and TEL exerts beneficial effects in the attenuation of CCl4-induced liver fibrosis in rats." @default.
• W2900643023 created "2018-11-29" @default.
• W2900643023 creator A5033903086 @default.
• W2900643023 creator A5038378713 @default.
• W2900643023 creator A5084799981 @default.
• W2900643023 date "2019-01-01" @default.
• W2900643023 modified "2023-10-18" @default.
• W2900643023 title "Modulation of inducible nitric oxide synthase pathway by eugenol and telmisartan in carbon tetrachloride-induced liver injury in rats" @default.
• W2900643023 cites W1506043065 @default.
• W2900643023 cites W1832953517 @default.
• W2900643023 cites W1963633297 @default.
• W2900643023 cites W1967291007 @default.
• W2900643023 cites W1968494226 @default.
• W2900643023 cites W1971033557 @default.
• W2900643023 cites W1976777085 @default.
• W2900643023 cites W1981262534 @default.
• W2900643023 cites W1983310681 @default.
• W2900643023 cites W1983465854 @default.
• W2900643023 cites W1983709889 @default.
• W2900643023 cites W1989268736 @default.
• W2900643023 cites W1989468718 @default.
• W2900643023 cites W1998469963 @default.
• W2900643023 cites W1999700055 @default.
• W2900643023 cites W2001398345 @default.
• W2900643023 cites W2006708785 @default.
• W2900643023 cites W2007452107 @default.
• W2900643023 cites W2017058203 @default.
• W2900643023 cites W2020253830 @default.
• W2900643023 cites W2020780884 @default.
• W2900643023 cites W2024040797 @default.
• W2900643023 cites W2025780125 @default.
• W2900643023 cites W2027957531 @default.
• W2900643023 cites W2029884920 @default.
• W2900643023 cites W2035954299 @default.
• W2900643023 cites W2045522851 @default.
• W2900643023 cites W2047936141 @default.
• W2900643023 cites W2049733183 @default.
• W2900643023 cites W2053749081 @default.
• W2900643023 cites W2056565128 @default.
• W2900643023 cites W2065348863 @default.
• W2900643023 cites W2068084277 @default.
• W2900643023 cites W2070761972 @default.
• W2900643023 cites W2077119788 @default.
• W2900643023 cites W2078854975 @default.
• W2900643023 cites W2085427506 @default.
• W2900643023 cites W2094029848 @default.
• W2900643023 cites W2099632798 @default.
• W2900643023 cites W2101937547 @default.
• W2900643023 cites W2116342732 @default.
• W2900643023 cites W2123098050 @default.
• W2900643023 cites W2129697991 @default.
• W2900643023 cites W2133204950 @default.
• W2900643023 cites W2145491327 @default.
• W2900643023 cites W2147962691 @default.
• W2900643023 cites W2175315926 @default.
• W2900643023 cites W2263023695 @default.
• W2900643023 cites W2291913215 @default.
• W2900643023 cites W2320770893 @default.
• W2900643023 cites W2409506259 @default.
• W2900643023 cites W2495031229 @default.
• W2900643023 cites W2790158372 @default.
• W2900643023 doi "https://doi.org/10.1016/j.lfs.2018.11.031" @default.
• W2900643023 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30452970" @default.
• W2900643023 hasPublicationYear "2019" @default.
• W2900643023 type Work @default.
• W2900643023 sameAs 2900643023 @default.
• W2900643023 citedByCount "40" @default.
• W2900643023 countsByYear W29006430232019 @default.
• W2900643023 countsByYear W29006430232020 @default.
• W2900643023 countsByYear W29006430232021 @default.
• W2900643023 countsByYear W29006430232022 @default.
• W2900643023 countsByYear W29006430232023 @default.
• W2900643023 crossrefType "journal-article" @default.
• W2900643023 hasAuthorship W2900643023A5033903086 @default.
• W2900643023 hasAuthorship W2900643023A5038378713 @default.
• W2900643023 hasAuthorship W2900643023A5084799981 @default.
• W2900643023 hasConcept C102124568 @default.
• W2900643023 hasConcept C126322002 @default.
• W2900643023 hasConcept C134018914 @default.
• W2900643023 hasConcept C178790620 @default.
• W2900643023 hasConcept C185592680 @default.
• W2900643023 hasConcept C2776151105 @default.
• W2900643023 hasConcept C2776637226 @default.
• W2900643023 hasConcept C2777359374 @default.
• W2900643023 hasConcept C2777622882 @default.
• W2900643023 hasConcept C2778401633 @default.
• W2900643023 hasConcept C519581460 @default.
• W2900643023 hasConcept C55493867 @default.
• W2900643023 hasConcept C71924100 @default.
• W2900643023 hasConcept C98274493 @default.
• W2900643023 hasConceptScore W2900643023C102124568 @default.
• W2900643023 hasConceptScore W2900643023C126322002 @default.
• W2900643023 hasConceptScore W2900643023C134018914 @default.
• W2900643023 hasConceptScore W2900643023C178790620 @default.
• W2900643023 hasConceptScore W2900643023C185592680 @default.
• W2900643023 hasConceptScore W2900643023C2776151105 @default.
• W2900643023 hasConceptScore W2900643023C2776637226 @default.
• W2900643023 hasConceptScore W2900643023C2777359374 @default.

• next