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- W2900666156 abstract "Background and purpose Myasthenia gravis activities of daily living (MG‐ADL) is a commonly used questionnaire in MG trials. To investigate whether MG ‐ ADL is equally sensitive to oculobulbar and generalized weakness, its correlation with the oculobulbar and generalized domain of the quantitative myasthenia gravis ( QMG ) score was analyzed ( QMG ob and QMG gen, respectively). To test whether the sensitivity of MG ‐ ADL for generalized weakness could be improved, the additional value of ACTIVLIM on top of MG‐ADL in the prediction QMGgen in was investigated. Methods MG‐ADL, QMG and ACTIVLIM , an ADL questionnaire focusing on generalized weakness, were analyzed in a prospective cohort of 112 MG patients. A generalized linear model was used to calculate the correlation of MG ‐ ADL with QMG ob and QMG gen and to assess the additional value of ACTIVLIM on top of MG ‐ ADL for its correlation with QMG gen. Results MG‐ADL had a higher correlation with QMG ob than with QMG gen ( B = 0.68, P < 0.001, and B = 0.38, P < 0.001, respectively). A similar trend was found for changes in the scores ( B = 0.68, P = 0.132, and B = 0.39, P = 0.492, respectively). ACTIVLIM had a significant additional value on top of MG ‐ ADL in the prediction of QMG gen, both cross‐sectionally ( B = −0.61, P < 0.001) and for changes within individual patients ( B = −0.93, P = 0.041). Conclusion MG‐ADL has a lower sensitivity for generalized weakness than for oculobulbar weakness. Adding questions on generalized weakness would improve the sensitivity of the MG ‐ ADL for generalized weakness." @default.
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- W2900666156 date "2018-12-17" @default.
- W2900666156 modified "2023-09-27" @default.
- W2900666156 title "Sensitivity of MG‐ADL for generalized weakness in myasthenia gravis" @default.
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- W2900666156 doi "https://doi.org/10.1111/ene.13867" @default.
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