FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2900670249> ?p ?o ?g. }

• W2900670249 abstract "In the surgical treatment of vulvar squamous‐cell carcinoma (VSCC), tumor‐free margins of 8 mm or more are considered adequate. However, limited perioperative information on the tumor‐free margins other than the surgeon's own estimation is available. The purpose of this study was therefore to investigate the feasibility of ex vivo MRI in localizing VSCC and to assess the surgical tumor‐free margins in fresh radical local excision (RLE) specimens to guide the surgeon during resections. Nine patients with biopsy‐proven VSCC scheduled for RLE were prospectively included. Intact fresh specimens were scanned using a 7 T preclinical MR‐scanner. Whole mount H&E‐stained slides were obtained every 3 mm and correlated with ex vivo MRI. A pathologist annotated VSCC and minimal tumor‐free margins (3 o'clock, 9 o'clock, basal) on the digitalized histological slides. An observer with knowledge of histology (the non‐blinded annotation) and a radiologist blinded to histology (the blinded annotation) separately performed annotation of the same features on ex vivo MRI. Linear correlation and agreement of the ex vivo MRI measurements with histology were assessed. Diagnostic performance for VSCC localization and identification of margins less than 8 mm was expressed as positive and negative predictive values (PPV, NPV). In 153 matched ex vivo MRI slices, the observer correctly identified 79/91 margins as less than 8 mm (PPV 87%) and 110/124 margins as 8 mm or greater (NPV 89%). The radiologist correctly annotated absence of VSCC in 73/81 (NPV 90%) and presence in 65/72 (PPV 90%) slices. Sixty‐four of 90 margins were correctly identified as less than 8 mm (PPV 71%) and 83/102 margins as 8 mm or greater (NPV 81%). Both non‐blinded and blinded annotations were linearly correlated and demonstrated good agreement with histology. Accurate localization of VSCC and measurements of the surgical tumor‐free margins in fresh RLE specimens using ex vivo MRI seems feasible. High diagnostic performance in VSCC localization and identification of margins less than 8 mm suggest ex vivo MRI to be clinically applicable." @default.
• W2900670249 created "2018-11-29" @default.
• W2900670249 creator A5000448641 @default.
• W2900670249 creator A5011591011 @default.
• W2900670249 creator A5039133993 @default.
• W2900670249 creator A5053996737 @default.
• W2900670249 creator A5055817835 @default.
• W2900670249 creator A5057003626 @default.
• W2900670249 creator A5061307922 @default.
• W2900670249 creator A5073067998 @default.
• W2900670249 date "2018-11-15" @default.
• W2900670249 modified "2023-10-18" @default.
• W2900670249 title "MRI evaluation of vulvar squamous-cell carcinoma in fresh radical local excision specimens for cancer localization and prediction of surgical tumor-free margins" @default.
• W2900670249 cites W1560395071 @default.
• W2900670249 cites W1766737038 @default.
• W2900670249 cites W1843533268 @default.
• W2900670249 cites W1976440161 @default.
• W2900670249 cites W1985716116 @default.
• W2900670249 cites W1987869189 @default.
• W2900670249 cites W2001835712 @default.
• W2900670249 cites W2007518614 @default.
• W2900670249 cites W2008030359 @default.
• W2900670249 cites W2014972306 @default.
• W2900670249 cites W2034068931 @default.
• W2900670249 cites W2037683731 @default.
• W2900670249 cites W2047473340 @default.
• W2900670249 cites W2049536465 @default.
• W2900670249 cites W2050807317 @default.
• W2900670249 cites W2052243126 @default.
• W2900670249 cites W2056721934 @default.
• W2900670249 cites W2061270788 @default.
• W2900670249 cites W2075087025 @default.
• W2900670249 cites W2075415215 @default.
• W2900670249 cites W2092992238 @default.
• W2900670249 cites W2114141365 @default.
• W2900670249 cites W2127659772 @default.
• W2900670249 cites W2128314982 @default.
• W2900670249 cites W2134690707 @default.
• W2900670249 cites W2140486893 @default.
• W2900670249 cites W2141773937 @default.
• W2900670249 cites W2152575748 @default.
• W2900670249 cites W2235523093 @default.
• W2900670249 cites W2419251028 @default.
• W2900670249 cites W2507789829 @default.
• W2900670249 cites W2581518756 @default.
• W2900670249 cites W2624491238 @default.
• W2900670249 doi "https://doi.org/10.1002/nbm.4025" @default.
• W2900670249 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6587990" @default.
• W2900670249 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30431192" @default.
• W2900670249 hasPublicationYear "2018" @default.
• W2900670249 type Work @default.
• W2900670249 sameAs 2900670249 @default.
• W2900670249 citedByCount "3" @default.
• W2900670249 countsByYear W29006702492020 @default.
• W2900670249 countsByYear W29006702492021 @default.
• W2900670249 countsByYear W29006702492022 @default.
• W2900670249 crossrefType "journal-article" @default.
• W2900670249 hasAuthorship W2900670249A5000448641 @default.
• W2900670249 hasAuthorship W2900670249A5011591011 @default.
• W2900670249 hasAuthorship W2900670249A5039133993 @default.
• W2900670249 hasAuthorship W2900670249A5053996737 @default.
• W2900670249 hasAuthorship W2900670249A5055817835 @default.
• W2900670249 hasAuthorship W2900670249A5057003626 @default.
• W2900670249 hasAuthorship W2900670249A5061307922 @default.
• W2900670249 hasAuthorship W2900670249A5073067998 @default.
• W2900670249 hasBestOaLocation W29006702491 @default.
• W2900670249 hasConcept C126838900 @default.
• W2900670249 hasConcept C142724271 @default.
• W2900670249 hasConcept C143409427 @default.
• W2900670249 hasConcept C150903083 @default.
• W2900670249 hasConcept C207001950 @default.
• W2900670249 hasConcept C26291073 @default.
• W2900670249 hasConcept C2775934546 @default.
• W2900670249 hasConcept C2989005 @default.
• W2900670249 hasConcept C3019992690 @default.
• W2900670249 hasConcept C31174226 @default.
• W2900670249 hasConcept C57742111 @default.
• W2900670249 hasConcept C71924100 @default.
• W2900670249 hasConcept C86803240 @default.
• W2900670249 hasConceptScore W2900670249C126838900 @default.
• W2900670249 hasConceptScore W2900670249C142724271 @default.
• W2900670249 hasConceptScore W2900670249C143409427 @default.
• W2900670249 hasConceptScore W2900670249C150903083 @default.
• W2900670249 hasConceptScore W2900670249C207001950 @default.
• W2900670249 hasConceptScore W2900670249C26291073 @default.
• W2900670249 hasConceptScore W2900670249C2775934546 @default.
• W2900670249 hasConceptScore W2900670249C2989005 @default.
• W2900670249 hasConceptScore W2900670249C3019992690 @default.
• W2900670249 hasConceptScore W2900670249C31174226 @default.
• W2900670249 hasConceptScore W2900670249C57742111 @default.
• W2900670249 hasConceptScore W2900670249C71924100 @default.
• W2900670249 hasConceptScore W2900670249C86803240 @default.
• W2900670249 hasIssue "1" @default.
• W2900670249 hasLocation W29006702491 @default.
• W2900670249 hasLocation W29006702492 @default.
• W2900670249 hasLocation W29006702493 @default.
• W2900670249 hasLocation W29006702494 @default.
• W2900670249 hasOpenAccess W2900670249 @default.
• W2900670249 hasPrimaryLocation W29006702491 @default.
• W2900670249 hasRelatedWork W2037182962 @default.

• next