FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2900693695> ?p ?o ?g. }

• W2900693695 abstract "Synovial sarcoma tumours contain a characteristic fusion protein, SS18-SSX, which drives disease development. Targeting oncogenic fusion proteins presents an attractive therapeutic opportunity. However, SS18-SSX has proven intractable for therapeutic intervention. Using a domain-focused CRISPR screen we identified the bromodomain of BRD9 as a critical functional dependency in synovial sarcoma. BRD9 is a component of SS18-SSX containing BAF complexes in synovial sarcoma cells; and integration of BRD9 into these complexes is critical for cell growth. Moreover BRD9 and SS18-SSX co-localize extensively on the synovial sarcoma genome. Remarkably, synovial sarcoma cells are highly sensitive to a novel small molecule degrader of BRD9, while other sarcoma subtypes are unaffected. Degradation of BRD9 induces downregulation of oncogenic transcriptional programs and inhibits tumour progression in vivo. We demonstrate that BRD9 supports oncogenic mechanisms underlying the SS18-SSX fusion in synovial sarcoma and highlight targeted degradation of BRD9 as a potential therapeutic opportunity in this disease." @default.
• W2900693695 created "2018-11-29" @default.
• W2900693695 creator A5006404204 @default.
• W2900693695 creator A5011165297 @default.
• W2900693695 creator A5012956545 @default.
• W2900693695 creator A5014909932 @default.
• W2900693695 creator A5015010943 @default.
• W2900693695 creator A5015474131 @default.
• W2900693695 creator A5022352605 @default.
• W2900693695 creator A5033773796 @default.
• W2900693695 creator A5037115007 @default.
• W2900693695 creator A5038387953 @default.
• W2900693695 creator A5043149847 @default.
• W2900693695 creator A5057948821 @default.
• W2900693695 creator A5060964091 @default.
• W2900693695 creator A5072926885 @default.
• W2900693695 creator A5073346894 @default.
• W2900693695 creator A5076974924 @default.
• W2900693695 creator A5091562783 @default.
• W2900693695 date "2018-11-15" @default.
• W2900693695 modified "2023-10-14" @default.
• W2900693695 title "Targeted degradation of BRD9 reverses oncogenic gene expression in synovial sarcoma" @default.
• W2900693695 cites W1635615463 @default.
• W2900693695 cites W1904339445 @default.
• W2900693695 cites W1967297034 @default.
• W2900693695 cites W1976128449 @default.
• W2900693695 cites W1978867804 @default.
• W2900693695 cites W1984838097 @default.
• W2900693695 cites W1986656413 @default.
• W2900693695 cites W1994568630 @default.
• W2900693695 cites W2004966039 @default.
• W2900693695 cites W2017325023 @default.
• W2900693695 cites W2025847887 @default.
• W2900693695 cites W2037199116 @default.
• W2900693695 cites W2038496720 @default.
• W2900693695 cites W2044351445 @default.
• W2900693695 cites W2057460011 @default.
• W2900693695 cites W2060484997 @default.
• W2900693695 cites W2080752012 @default.
• W2900693695 cites W2086797990 @default.
• W2900693695 cites W2108549889 @default.
• W2900693695 cites W2108740070 @default.
• W2900693695 cites W2118471037 @default.
• W2900693695 cites W2119079421 @default.
• W2900693695 cites W2124328974 @default.
• W2900693695 cites W2127736279 @default.
• W2900693695 cites W2128551987 @default.
• W2900693695 cites W2145234793 @default.
• W2900693695 cites W2146938620 @default.
• W2900693695 cites W2148297520 @default.
• W2900693695 cites W2149047387 @default.
• W2900693695 cites W2155309830 @default.
• W2900693695 cites W2160060092 @default.
• W2900693695 cites W2163261207 @default.
• W2900693695 cites W2166310590 @default.
• W2900693695 cites W2172177942 @default.
• W2900693695 cites W2180985467 @default.
• W2900693695 cites W2269379690 @default.
• W2900693695 cites W2286718346 @default.
• W2900693695 cites W2298612765 @default.
• W2900693695 cites W2314012478 @default.
• W2900693695 cites W2322132473 @default.
• W2900693695 cites W2464821864 @default.
• W2900693695 cites W2567190685 @default.
• W2900693695 cites W2605411274 @default.
• W2900693695 cites W2734897764 @default.
• W2900693695 cites W2739511077 @default.
• W2900693695 cites W2765468373 @default.
• W2900693695 cites W2784755083 @default.
• W2900693695 cites W2793444178 @default.
• W2900693695 cites W2796292093 @default.
• W2900693695 cites W2796408191 @default.
• W2900693695 cites W2806892701 @default.
• W2900693695 cites W2900693695 @default.
• W2900693695 cites W848101669 @default.
• W2900693695 doi "https://doi.org/10.7554/elife.41305" @default.
• W2900693695 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6277197" @default.
• W2900693695 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30431433" @default.
• W2900693695 hasPublicationYear "2018" @default.
• W2900693695 type Work @default.
• W2900693695 sameAs 2900693695 @default.
• W2900693695 citedByCount "111" @default.
• W2900693695 countsByYear W29006936952018 @default.
• W2900693695 countsByYear W29006936952019 @default.
• W2900693695 countsByYear W29006936952020 @default.
• W2900693695 countsByYear W29006936952021 @default.
• W2900693695 countsByYear W29006936952022 @default.
• W2900693695 countsByYear W29006936952023 @default.
• W2900693695 crossrefType "journal-article" @default.
• W2900693695 hasAuthorship W2900693695A5006404204 @default.
• W2900693695 hasAuthorship W2900693695A5011165297 @default.
• W2900693695 hasAuthorship W2900693695A5012956545 @default.
• W2900693695 hasAuthorship W2900693695A5014909932 @default.
• W2900693695 hasAuthorship W2900693695A5015010943 @default.
• W2900693695 hasAuthorship W2900693695A5015474131 @default.
• W2900693695 hasAuthorship W2900693695A5022352605 @default.
• W2900693695 hasAuthorship W2900693695A5033773796 @default.
• W2900693695 hasAuthorship W2900693695A5037115007 @default.
• W2900693695 hasAuthorship W2900693695A5038387953 @default.
• W2900693695 hasAuthorship W2900693695A5043149847 @default.

• next