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• W2900693732 startingPage "e1007430" @default.
• W2900693732 abstract "Lassa virus (LASV) is responsible for a viral hemorrhagic fever in humans and the death of 3,000 to 5,000 people every year. The immune response to LASV is poorly understood, but type I interferon (IFN-I) and T-cell responses appear to be critical for the host. We studied the response of myeloid dendritic cells (mDC) to LASV, as mDCs are involved in both IFN-I production and T-cell activation. We compared the response of primary human mDCs to LASV and Mopeia virus (MOPV), which is similar to LASV, but non-pathogenic. We showed that mDCs produced substantial amounts of IFN-I in response to both LASV and MOPV. However, only MOPV-infected mDCs were able to activate T cells. More surprisingly, coculture with T cells completely inhibited the activation of LASV-infected mDCs. These differences between LASV and MOPV were mostly due to the LASV nucleoprotein, which has major immunosuppressive properties, but the glycoprotein was also involved. Overall, these results suggest that mDCs may be important for the global response to LASV and play a role in the outcome of Lassa fever." @default.
• W2900693732 created "2018-11-29" @default.
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• W2900693732 date "2018-11-12" @default.
• W2900693732 modified "2023-10-17" @default.
• W2900693732 title "Lassa virus activates myeloid dendritic cells but suppresses their ability to stimulate T cells" @default.
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• W2900693732 doi "https://doi.org/10.1371/journal.ppat.1007430" @default.
• W2900693732 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6258464" @default.
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• W2900693732 hasPublicationYear "2018" @default.
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