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- W2900718904 endingPage "117" @default.
- W2900718904 startingPage "110" @default.
- W2900718904 abstract "Cell cooperation promotes many of the hallmarks of cancer via the secretion of diffusible factors that can affect cancer cells or stromal cells in the tumour microenvironment. This cooperation cannot be explained simply as the collective action of cells for the benefit of the tumour because non-cooperative subclones can constantly invade and free-ride on the diffusible factors produced by the cooperative cells. A full understanding of cooperation among the cells of a tumour requires methods and concepts from evolutionary game theory, which has been used successfully in other areas of biology to understand similar problems but has been underutilized in cancer research. Game theory can provide insights into the stability of cooperation among cells in a tumour and into the design of potentially evolution-proof therapies that disrupt this cooperation. This Opinion argues that understanding the interactions between cells that occur in tumours requires concepts from evolutionary game theory. Game theory can provide insights into the stability of cooperation among cells in a tumour and how this might be used therapeutically." @default.
- W2900718904 created "2018-11-29" @default.
- W2900718904 creator A5005001958 @default.
- W2900718904 creator A5064878844 @default.
- W2900718904 date "2018-11-23" @default.
- W2900718904 modified "2023-10-18" @default.
- W2900718904 title "Cooperation among cancer cells: applying game theory to cancer" @default.
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