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• W2900730140 endingPage "176" @default.
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• W2900730140 abstract "Bone marrow mesenchymal stromal cells (BM-MSCs) are referred as a promising immunotherapeutic cell product. New approaches using empowered MSCs should be developed as for the treatment or prevention of different immunological diseases. Such preconditioning by new licensing stimuli will empower the immune fate of BM-MSCs and, therefore, promote a better and more efficient biological. Here, our main goal was to establish the immunological profile of BM-MSCs following inflammatory priming and in particular their capacity to adjust their immune-related proteome and transcriptome.To run this study, we have used BM-MSC cell cultures, a pro-inflammatory cytokine cocktail priming, flow cytometry analysis, qPCR and ELISA techniques.Different expression levels of several immunological mediators such as COX-1, COX-2, LIF, HGF, Gal-1, HO-1, IL-11, IL-8, IL-6 and TGF-β were constitutively observed in BM-MSCs. Inflammation priming substantially but differentially modulated the gene and protein expression profiles of these mediators. Thus, expressions of COX-2, LIF, HGF, IL-11, IL-8 and IL-6 were highly increased/induced and those of COX-1, Gal-1, and TGF-β were reduced.Collectively, we demonstrated that BM-MSCs are endowed with a specific and modular regulatory machinery which is potentially involved in immunomodulation. Moreover, BM-MSCs are highly sensitive to inflammation and respond to such signal by properly adjusting their gene and protein expression of regulatory factors. Using such preconditioning may empower the immune fate of MSCs and, therefore, enhance their value for cell-based immunotherapy." @default.
• W2900730140 created "2018-11-29" @default.
• W2900730140 creator A5003191648 @default.
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• W2900730140 date "2018-11-14" @default.
• W2900730140 modified "2023-10-01" @default.
• W2900730140 title "Empowering the immune fate of bone marrow mesenchymal stromal cells: gene and protein changes" @default.
• W2900730140 cites W123039403 @default.
• W2900730140 cites W1508798545 @default.
• W2900730140 cites W1551976873 @default.
• W2900730140 cites W1568069191 @default.
• W2900730140 cites W1597881733 @default.
• W2900730140 cites W1779654418 @default.
• W2900730140 cites W1824670638 @default.
• W2900730140 cites W1905514274 @default.
• W2900730140 cites W1920637882 @default.
• W2900730140 cites W1935912749 @default.
• W2900730140 cites W1949227094 @default.
• W2900730140 cites W1963811038 @default.
• W2900730140 cites W1976823577 @default.
• W2900730140 cites W1977454958 @default.
• W2900730140 cites W1994594051 @default.
• W2900730140 cites W1995286643 @default.
• W2900730140 cites W1999676511 @default.
• W2900730140 cites W2002463533 @default.
• W2900730140 cites W2002661570 @default.
• W2900730140 cites W2005477804 @default.
• W2900730140 cites W2010096412 @default.
• W2900730140 cites W2017051726 @default.
• W2900730140 cites W2019495971 @default.
• W2900730140 cites W2020335918 @default.
• W2900730140 cites W2022915249 @default.
• W2900730140 cites W2022982343 @default.
• W2900730140 cites W2025371271 @default.
• W2900730140 cites W2033333095 @default.
• W2900730140 cites W2036334656 @default.
• W2900730140 cites W2038399651 @default.
• W2900730140 cites W2043465498 @default.
• W2900730140 cites W2048265787 @default.
• W2900730140 cites W2055426730 @default.
• W2900730140 cites W2057984458 @default.
• W2900730140 cites W2058458618 @default.
• W2900730140 cites W2061172918 @default.
• W2900730140 cites W2062042885 @default.
• W2900730140 cites W2065828375 @default.
• W2900730140 cites W2071904806 @default.
• W2900730140 cites W2074084795 @default.
• W2900730140 cites W2074127181 @default.
• W2900730140 cites W2078282038 @default.
• W2900730140 cites W2083156208 @default.
• W2900730140 cites W2087353148 @default.
• W2900730140 cites W2087521550 @default.
• W2900730140 cites W2089442121 @default.
• W2900730140 cites W2091552026 @default.
• W2900730140 cites W2097147259 @default.
• W2900730140 cites W2105151699 @default.
• W2900730140 cites W2105674052 @default.
• W2900730140 cites W2110463517 @default.
• W2900730140 cites W2113313714 @default.
• W2900730140 cites W2124117129 @default.
• W2900730140 cites W2128149258 @default.
• W2900730140 cites W2137108257 @default.
• W2900730140 cites W2159358845 @default.
• W2900730140 cites W2166672922 @default.
• W2900730140 cites W2167017590 @default.
• W2900730140 cites W2180209577 @default.
• W2900730140 cites W2193999202 @default.
• W2900730140 cites W2235029947 @default.
• W2900730140 cites W2270357641 @default.
• W2900730140 cites W2273633245 @default.
• W2900730140 cites W2299564167 @default.
• W2900730140 cites W2315305779 @default.
• W2900730140 cites W2467979029 @default.
• W2900730140 cites W2521135883 @default.
• W2900730140 cites W2522760612 @default.
• W2900730140 cites W2774129885 @default.
• W2900730140 cites W2786024057 @default.
• W2900730140 cites W2794710654 @default.
• W2900730140 cites W2069519906 @default.
• W2900730140 doi "https://doi.org/10.1007/s00011-018-1198-8" @default.
• W2900730140 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30426152" @default.
• W2900730140 hasPublicationYear "2018" @default.
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