Matches in SemOpenAlex for { <https://semopenalex.org/work/W2900758712> ?p ?o ?g. }
- W2900758712 abstract "Aims: To investigate the relationship between the miR-130a polymorphism rs731384 and coronary artery disease (CAD) and to further explore the molecular mechanism of the pathogenesis of CAD, an observational single-center study was conducted. Method: A total of 876 subjects were recruited in the present study. Four milliliters of venous blood was drawn after 12 h of fasting to perform biochemical assays. CAD patients and controls were distinguished by coronary angiography. Rs731384 was genotyped on the Agena MassARRAY system according to the manufacturer’s user guide. Statistical analysis was conducted using SPSS 16.0 software. Results: The study found that the plasma levels of total cholesterol (TC) (P=0.006), low-density lipoprotein cholesterol (LDL-C) (P=0.030), apolipoprotein A (ApoA) (P=0.038), and apolipoprotein B (ApoB) (P=0.022) distributed differently in patients with various alleles. Additionally, the AA genotype of rs731384 was found to be a protective factor against CAD in a recessive model (AA:AG+GG, odds ratio (OR) = 0.408, 95% confidence interval (95% CI) = 0.171–0.973, P=0.043). A significant association was found between the gene–environment interaction and CAD risk. The AA genotype along with high-density lipoprotein cholesterol (HDL-C) level ≥ 1.325 mmol/l significantly decreased the CAD risk (AA:AG+GG, OR = 0.117, 95% CI = 0.023–0.588, P=0.009). Conclusion: The mutant AA genotype of rs731384 seems to be a protective factor against CAD, and rs731384 plays an important role in the human metabolism of plasma lipids." @default.
- W2900758712 created "2018-11-29" @default.
- W2900758712 creator A5003146115 @default.
- W2900758712 creator A5006938103 @default.
- W2900758712 creator A5021507286 @default.
- W2900758712 creator A5033456347 @default.
- W2900758712 creator A5035295203 @default.
- W2900758712 creator A5047757729 @default.
- W2900758712 creator A5052760599 @default.
- W2900758712 creator A5056398014 @default.
- W2900758712 creator A5061443513 @default.
- W2900758712 creator A5075076354 @default.
- W2900758712 creator A5076042378 @default.
- W2900758712 creator A5080337025 @default.
- W2900758712 date "2018-12-18" @default.
- W2900758712 modified "2023-10-03" @default.
- W2900758712 title "Single-nucleotide polymorphism rs731384 is associated with plasma lipid levels and the risk of coronary artery disease in Chinese populations" @default.
- W2900758712 cites W111976367 @default.
- W2900758712 cites W149694075 @default.
- W2900758712 cites W1633080376 @default.
- W2900758712 cites W1963856902 @default.
- W2900758712 cites W1970279890 @default.
- W2900758712 cites W1985780819 @default.
- W2900758712 cites W1989258056 @default.
- W2900758712 cites W1993514777 @default.
- W2900758712 cites W1996466274 @default.
- W2900758712 cites W2009784487 @default.
- W2900758712 cites W2020106916 @default.
- W2900758712 cites W2036232093 @default.
- W2900758712 cites W2059537042 @default.
- W2900758712 cites W2065667781 @default.
- W2900758712 cites W2069163947 @default.
- W2900758712 cites W2097055412 @default.
- W2900758712 cites W2106509101 @default.
- W2900758712 cites W2113709912 @default.
- W2900758712 cites W2133188156 @default.
- W2900758712 cites W2149762754 @default.
- W2900758712 cites W2154836846 @default.
- W2900758712 cites W2195706369 @default.
- W2900758712 cites W2232908159 @default.
- W2900758712 cites W2291346814 @default.
- W2900758712 cites W2304671516 @default.
- W2900758712 cites W2318920459 @default.
- W2900758712 cites W2415767860 @default.
- W2900758712 cites W250534206 @default.
- W2900758712 cites W2529025963 @default.
- W2900758712 cites W2600175314 @default.
- W2900758712 cites W2614578122 @default.
- W2900758712 cites W2699220065 @default.
- W2900758712 cites W2742753684 @default.
- W2900758712 cites W2772073928 @default.
- W2900758712 cites W2800394734 @default.
- W2900758712 cites W4293409918 @default.
- W2900758712 doi "https://doi.org/10.1042/bsr20181502" @default.
- W2900758712 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6435504" @default.
- W2900758712 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30429231" @default.
- W2900758712 hasPublicationYear "2018" @default.
- W2900758712 type Work @default.
- W2900758712 sameAs 2900758712 @default.
- W2900758712 citedByCount "3" @default.
- W2900758712 countsByYear W29007587122019 @default.
- W2900758712 countsByYear W29007587122020 @default.
- W2900758712 countsByYear W29007587122021 @default.
- W2900758712 crossrefType "journal-article" @default.
- W2900758712 hasAuthorship W2900758712A5003146115 @default.
- W2900758712 hasAuthorship W2900758712A5006938103 @default.
- W2900758712 hasAuthorship W2900758712A5021507286 @default.
- W2900758712 hasAuthorship W2900758712A5033456347 @default.
- W2900758712 hasAuthorship W2900758712A5035295203 @default.
- W2900758712 hasAuthorship W2900758712A5047757729 @default.
- W2900758712 hasAuthorship W2900758712A5052760599 @default.
- W2900758712 hasAuthorship W2900758712A5056398014 @default.
- W2900758712 hasAuthorship W2900758712A5061443513 @default.
- W2900758712 hasAuthorship W2900758712A5075076354 @default.
- W2900758712 hasAuthorship W2900758712A5076042378 @default.
- W2900758712 hasAuthorship W2900758712A5080337025 @default.
- W2900758712 hasBestOaLocation W29007587121 @default.
- W2900758712 hasConcept C104317684 @default.
- W2900758712 hasConcept C126322002 @default.
- W2900758712 hasConcept C134018914 @default.
- W2900758712 hasConcept C135763542 @default.
- W2900758712 hasConcept C153209595 @default.
- W2900758712 hasConcept C156957248 @default.
- W2900758712 hasConcept C180754005 @default.
- W2900758712 hasConcept C2778163477 @default.
- W2900758712 hasConcept C2778213512 @default.
- W2900758712 hasConcept C2780942790 @default.
- W2900758712 hasConcept C43044207 @default.
- W2900758712 hasConcept C44249647 @default.
- W2900758712 hasConcept C50440223 @default.
- W2900758712 hasConcept C54355233 @default.
- W2900758712 hasConcept C62746215 @default.
- W2900758712 hasConcept C71924100 @default.
- W2900758712 hasConcept C86803240 @default.
- W2900758712 hasConcept C90924648 @default.
- W2900758712 hasConceptScore W2900758712C104317684 @default.
- W2900758712 hasConceptScore W2900758712C126322002 @default.
- W2900758712 hasConceptScore W2900758712C134018914 @default.
- W2900758712 hasConceptScore W2900758712C135763542 @default.
- W2900758712 hasConceptScore W2900758712C153209595 @default.