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- W2900770371 abstract "Phenolic compounds such as pentachlorophenol (PCP), triclosan, and 2,4-dichlorophenoxyacetic acid (2,4-D) represent a common class of anthropogenic biocides. Despite the novelty of these compounds, many can be degraded by microbes isolated from contaminated sites. However, degradation of this class of chemicals often generates toxic intermediates, which may contribute to their recalcitrance to biodegradation. We have addressed the stresses associated with degradation of PCP by Sphingobium chlorophenolicum by examining the transcriptional response after PCP exposure and identifying genes necessary for growth during both exposure to and degradation of PCP. This work identifies some of the mechanisms that protect cells from this toxic compound and facilitate its degradation. This information could be used to engineer strains capable of improved biodegradation of PCP or similar phenolic pollutants." @default.
- W2900770371 created "2018-11-29" @default.
- W2900770371 creator A5008773168 @default.
- W2900770371 creator A5051987215 @default.
- W2900770371 date "2018-10-30" @default.
- W2900770371 modified "2023-09-27" @default.
- W2900770371 title "Genome-Wide Analysis of Transcriptional Changes and Genes That Contribute to Fitness during Degradation of the Anthropogenic Pollutant Pentachlorophenol by Sphingobium chlorophenolicum" @default.
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- W2900770371 doi "https://doi.org/10.1128/msystems.00275-18" @default.
- W2900770371 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6247019" @default.
- W2900770371 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30505947" @default.
- W2900770371 hasPublicationYear "2018" @default.
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