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- W2900773338 endingPage "209" @default.
- W2900773338 startingPage "201" @default.
- W2900773338 abstract "Oncolytic virus therapy is a promising new option for cancer. It utilizes genetically engineered or naturally occurring viruses that selectively replicate in and kill cancer cells without harming normal cells. T-VEC (talimogene laherparepvec), a second-generation oncolytic herpes simplex virus type 1, was approved by the US Food and Drug Administration for the treatment of inoperable melanoma in 2015 and subsequently approved in Europe in 2016. Other oncolytic viruses using different parental viruses have also been tested in Phase III clinical trials and are ready for drug approval: Pexa-Vec (pexastimogene devacirepvec), an oncolytic vaccinia virus, CG0070, an oncolytic adenovirus, and REOLYSIN (pelareorep), an oncolytic reovirus. In Japan, as of May 2018, several oncolytic viruses have been developed, and some have already proceeded to clinical trials. In this review, we summarize clinical trials assessing oncolytic virus therapy that were conducted or are currently ongoing in Japan, specifically, T-VEC, the abovementioned oncolytic herpes simplex virus type 1, G47Δ, a third-generation oncolytic herpes simplex virus type 1, HF10, a naturally attenuated oncolytic herpes simplex virus type 1, Telomelysin, an oncolytic adenovirus, Surv.m-CRA, another oncolytic adenovirus, and Sendai virus particle. In the near future, oncolytic virus therapy may become an important and major treatment option for cancer in Japan." @default.
- W2900773338 created "2018-11-29" @default.
- W2900773338 creator A5044494440 @default.
- W2900773338 creator A5046264170 @default.
- W2900773338 creator A5055180595 @default.
- W2900773338 date "2018-11-20" @default.
- W2900773338 modified "2023-10-11" @default.
- W2900773338 title "Oncolytic virus therapy in Japan: progress in clinical trials and future perspectives" @default.
- W2900773338 cites W1225417585 @default.
- W2900773338 cites W1490628679 @default.
- W2900773338 cites W1542708858 @default.
- W2900773338 cites W1670726526 @default.
- W2900773338 cites W1964297270 @default.
- W2900773338 cites W1970212185 @default.
- W2900773338 cites W1974770666 @default.
- W2900773338 cites W1980973208 @default.
- W2900773338 cites W1981213347 @default.
- W2900773338 cites W1982457536 @default.
- W2900773338 cites W1993100987 @default.
- W2900773338 cites W1993835312 @default.
- W2900773338 cites W1994778014 @default.
- W2900773338 cites W1996996990 @default.
- W2900773338 cites W1998342624 @default.
- W2900773338 cites W1999009503 @default.
- W2900773338 cites W2001405744 @default.
- W2900773338 cites W2002694645 @default.
- W2900773338 cites W2003516776 @default.
- W2900773338 cites W2007629275 @default.
- W2900773338 cites W2010523084 @default.
- W2900773338 cites W2011206688 @default.
- W2900773338 cites W2018106813 @default.
- W2900773338 cites W2019811064 @default.
- W2900773338 cites W2024209265 @default.
- W2900773338 cites W2025730665 @default.
- W2900773338 cites W2025822798 @default.
- W2900773338 cites W2026234789 @default.
- W2900773338 cites W2027719557 @default.
- W2900773338 cites W2030479138 @default.
- W2900773338 cites W2033077141 @default.
- W2900773338 cites W2034881941 @default.
- W2900773338 cites W2038709470 @default.
- W2900773338 cites W2039084800 @default.
- W2900773338 cites W2046239281 @default.
- W2900773338 cites W2046300989 @default.
- W2900773338 cites W2047014766 @default.
- W2900773338 cites W2047558272 @default.
- W2900773338 cites W2050349145 @default.
- W2900773338 cites W2051068137 @default.
- W2900773338 cites W2053062203 @default.
- W2900773338 cites W2055215223 @default.
- W2900773338 cites W2056650797 @default.
- W2900773338 cites W2057382033 @default.
- W2900773338 cites W2057611916 @default.
- W2900773338 cites W2058660954 @default.
- W2900773338 cites W2064752967 @default.
- W2900773338 cites W2071310073 @default.
- W2900773338 cites W2072564990 @default.
- W2900773338 cites W2075631864 @default.
- W2900773338 cites W2076228922 @default.
- W2900773338 cites W2078835828 @default.
- W2900773338 cites W2082150850 @default.
- W2900773338 cites W2083045544 @default.
- W2900773338 cites W2086011860 @default.
- W2900773338 cites W2086591619 @default.
- W2900773338 cites W2087257698 @default.
- W2900773338 cites W2091461372 @default.
- W2900773338 cites W2094101833 @default.
- W2900773338 cites W2098599594 @default.
- W2900773338 cites W2099648846 @default.
- W2900773338 cites W2100808704 @default.
- W2900773338 cites W2104630046 @default.
- W2900773338 cites W2107239059 @default.
- W2900773338 cites W2108883303 @default.
- W2900773338 cites W2109274792 @default.
- W2900773338 cites W2112035444 @default.
- W2900773338 cites W2116576715 @default.
- W2900773338 cites W2118728917 @default.
- W2900773338 cites W2119333435 @default.
- W2900773338 cites W2119819168 @default.
- W2900773338 cites W2128023051 @default.
- W2900773338 cites W2134216634 @default.
- W2900773338 cites W2137871019 @default.
- W2900773338 cites W2151262467 @default.
- W2900773338 cites W2155457105 @default.
- W2900773338 cites W2158897346 @default.
- W2900773338 cites W2160335399 @default.
- W2900773338 cites W2162863440 @default.
- W2900773338 cites W2165320653 @default.
- W2900773338 cites W2165652424 @default.
- W2900773338 cites W2171553929 @default.
- W2900773338 cites W2268591369 @default.
- W2900773338 cites W2316101052 @default.
- W2900773338 cites W2406631797 @default.
- W2900773338 cites W2413800984 @default.
- W2900773338 cites W2427476638 @default.
- W2900773338 cites W2497822529 @default.
- W2900773338 cites W2499685627 @default.
- W2900773338 cites W2596442933 @default.