FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2900781716> ?p ?o ?g. }

• W2900781716 endingPage "8114" @default.
• W2900781716 startingPage "8105" @default.
• W2900781716 abstract "BACKGROUND:The purpose of the study was to investigate the functional roles of phosphatase in regenerating liver-3 (PRL-3) in hepatocellular carcinoma (HCC), as well as the related molecular mechanisms. MATERIAL AND METHODS:HCC tissues and adjacent normal tissues were collected from 124 HCC patients. The mRNA and protein levels of PRL-3 were detected using quantitative real-time polymerase chain reaction (qRT-PCR) and Western blot assays, respectively. The relationship between PRL-3 expression and clinical characteristics of HCC patients was evaluated by chi-square test. MTT and Transwell assays were performed to estimate cell proliferation and motility, respectively. RESULTS:The expression of PRL-3 was significantly increased in HCC tissues and cells at both protein and mRNA levels (P<0.01 for all). Furthermore, the up-regulation of PRL-3 was positively correlated with hepatic vascular invasion (P=0.019), lymph node metastasis (P=0.012), and TNM stage (P=0.001). The knockdown of PRL-3 suppressed HCC cell proliferation, migration, and invasion, and PR3K/AKT pathway activity was also obviously inhibited in HCC cells with PRL-3 deficiency. The levels of PTEN were negatively associated with PRL-3 expression. PRL-3 might inhibit the protein level of PTEN through enhancing its phosphorylation level. The transfection of si-PTEN can reverse the anti-tumor action caused by PRL-3 knockdown in HCC cells. CONCLUSIONS:Up-regulation of PRL-3 may activate the PI3K/AKT signaling pathway and enhance malignant progression of HCC through targeting PTEN." @default.
• W2900781716 created "2018-11-29" @default.
• W2900781716 creator A5001951882 @default.
• W2900781716 creator A5004076371 @default.
• W2900781716 creator A5028306431 @default.
• W2900781716 creator A5029685360 @default.
• W2900781716 creator A5034332871 @default.
• W2900781716 creator A5041909283 @default.
• W2900781716 date "2018-11-12" @default.
• W2900781716 modified "2023-10-05" @default.
• W2900781716 title "Up-Regulation of Phosphatase in Regenerating Liver-3 (PRL-3) Contributes to Malignant Progression of Hepatocellular Carcinoma by Activating Phosphatase and Tensin Homolog Deleted on Chromosome Ten (PTEN)/Phosphoinositide 3-Kinase (PI3K)/AKT Signaling Pathway" @default.
• W2900781716 cites W1514966187 @default.
• W2900781716 cites W1675308597 @default.
• W2900781716 cites W1734521060 @default.
• W2900781716 cites W17382811 @default.
• W2900781716 cites W1985068428 @default.
• W2900781716 cites W1991713904 @default.
• W2900781716 cites W1995149018 @default.
• W2900781716 cites W2017104633 @default.
• W2900781716 cites W2023387621 @default.
• W2900781716 cites W2059665962 @default.
• W2900781716 cites W2063389506 @default.
• W2900781716 cites W2077492389 @default.
• W2900781716 cites W2082095180 @default.
• W2900781716 cites W2094017811 @default.
• W2900781716 cites W2130860611 @default.
• W2900781716 cites W2137623277 @default.
• W2900781716 cites W2144044603 @default.
• W2900781716 cites W2151305493 @default.
• W2900781716 cites W2274231538 @default.
• W2900781716 cites W2300882941 @default.
• W2900781716 cites W2325862385 @default.
• W2900781716 cites W2414125851 @default.
• W2900781716 cites W2426515022 @default.
• W2900781716 cites W2463431808 @default.
• W2900781716 cites W2514181134 @default.
• W2900781716 cites W2517068426 @default.
• W2900781716 cites W2548139789 @default.
• W2900781716 cites W2570618306 @default.
• W2900781716 cites W2596261485 @default.
• W2900781716 cites W2741614522 @default.
• W2900781716 cites W2797803168 @default.
• W2900781716 cites W2861688776 @default.
• W2900781716 cites W2883616472 @default.
• W2900781716 cites W2885961012 @default.
• W2900781716 cites W2887997618 @default.
• W2900781716 cites W2891603127 @default.
• W2900781716 cites W2893235627 @default.
• W2900781716 cites W2912874324 @default.
• W2900781716 cites W2917837889 @default.
• W2900781716 cites W4250958839 @default.
• W2900781716 cites W632664331 @default.
• W2900781716 doi "https://doi.org/10.12659/msm.913307" @default.
• W2900781716 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6243833" @default.
• W2900781716 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30418964" @default.
• W2900781716 hasPublicationYear "2018" @default.
• W2900781716 type Work @default.
• W2900781716 sameAs 2900781716 @default.
• W2900781716 citedByCount "10" @default.
• W2900781716 countsByYear W29007817162019 @default.
• W2900781716 countsByYear W29007817162020 @default.
• W2900781716 countsByYear W29007817162021 @default.
• W2900781716 countsByYear W29007817162022 @default.
• W2900781716 countsByYear W29007817162023 @default.
• W2900781716 crossrefType "journal-article" @default.
• W2900781716 hasAuthorship W2900781716A5001951882 @default.
• W2900781716 hasAuthorship W2900781716A5004076371 @default.
• W2900781716 hasAuthorship W2900781716A5028306431 @default.
• W2900781716 hasAuthorship W2900781716A5029685360 @default.
• W2900781716 hasAuthorship W2900781716A5034332871 @default.
• W2900781716 hasAuthorship W2900781716A5041909283 @default.
• W2900781716 hasBestOaLocation W29007817162 @default.
• W2900781716 hasConcept C11960822 @default.
• W2900781716 hasConcept C126322002 @default.
• W2900781716 hasConcept C173396325 @default.
• W2900781716 hasConcept C178666793 @default.
• W2900781716 hasConcept C190283241 @default.
• W2900781716 hasConcept C2777609662 @default.
• W2900781716 hasConcept C2778019345 @default.
• W2900781716 hasConcept C2779549131 @default.
• W2900781716 hasConcept C2781322055 @default.
• W2900781716 hasConcept C502942594 @default.
• W2900781716 hasConcept C54355233 @default.
• W2900781716 hasConcept C55493867 @default.
• W2900781716 hasConcept C62112901 @default.
• W2900781716 hasConcept C62478195 @default.
• W2900781716 hasConcept C71924100 @default.
• W2900781716 hasConcept C75217442 @default.
• W2900781716 hasConcept C86554907 @default.
• W2900781716 hasConcept C86803240 @default.
• W2900781716 hasConcept C95444343 @default.
• W2900781716 hasConceptScore W2900781716C11960822 @default.
• W2900781716 hasConceptScore W2900781716C126322002 @default.
• W2900781716 hasConceptScore W2900781716C173396325 @default.
• W2900781716 hasConceptScore W2900781716C178666793 @default.
• W2900781716 hasConceptScore W2900781716C190283241 @default.
• W2900781716 hasConceptScore W2900781716C2777609662 @default.
• W2900781716 hasConceptScore W2900781716C2778019345 @default.

• next