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• W2900782868 abstract "Abstract Sphingolipids such as ceramide have attracted much attention as possible anticancer agents due to their potent pro‐apoptotic effects. However, due to their extreme hydrophobicity, there is currently no clinically approved delivery method for in vivo use as a therapeutic agent. To this end, we have developed a novel method for loading the short‐chain C 6 ceramide onto oxidized graphene nanoribbons (O‐GNRs) and graphene nanoplatelets (GNPs). Mass spectrometry revealed loading efficiencies of 57% and 51.5% for C 6 ceramide onto O‐GNRs and GNPs, respectively. The PrestoBlue viability assay revealed that 100 µg/mL of C 6 ceramide‐loaded O‐GNRs and C 6 ceramide‐loaded GNPs reduced HeLa cell viability by approximately 93% and approximately 76%, respectively, compared to untreated HeLa cells, while equal concentrations of these nanoparticles without C 6 ceramide did not significantly reduce HeLa cell viability. We confirmed that this cytotoxicity was apoptotic in nature via capase‐3 activity and Hoechst staining. Using live‐cell confocal imaging with the fluorescent NBD‐ceramide loaded on O‐GNRs, we observed robust uptake into HeLa cells within 30 min while NBD‐ceramide on its own was uptaken much more rapidly. Transmission electron microscopy confirmed that C 6 ceramide‐loaded O‐GNRs were actually entering cells. Taken together, these data show that O‐GNRs are a promising delivery agent for ceramide. To our knowledge, this study is the first to use such a loading method. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 25–37, 2019." @default.
• W2900782868 created "2018-11-29" @default.
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• W2900782868 date "2018-11-13" @default.
• W2900782868 modified "2023-10-05" @default.
• W2900782868 title "Oxidized graphene nanoparticles as a delivery system for the pro-apoptotic sphingolipid C₆ ceramide" @default.
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• W2900782868 doi "https://doi.org/10.1002/jbm.a.36474" @default.
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