Matches in SemOpenAlex for { <https://semopenalex.org/work/W2900820805> ?p ?o ?g. }
- W2900820805 endingPage "5509" @default.
- W2900820805 startingPage "5509" @default.
- W2900820805 abstract "Purpose: To evaluate the effect of topical suberanilohydroxamic acid (SAHA) and 5-methyl-1-phenyl-2[1H]-pyridone (pirfenidone) on the degree of corneal haze in the stromal wounded ex vivo canine cornea. Methods: Twenty-four corneoscleral rims from normal dogs were uniformly wounded with an excimer laser and placed into culture medium with an air–liquid interface. The control group (n = 8) contained placebo-treated corneas. Treatment group 1 (n = 8) received SAHA topically every 6 hours. Treatment group 2 (n = 8) received pirfenidone topically every 6 hours. Each cornea was fluorescein stained and macrophotographed every 6 hours to assess epithelialization rate. All corneas were also macrophotographed weekly to assess optical clarity (haze). Images were analyzed for differences in pixel intensity between wounded (haze) and unwounded (nonhaze) regions, and haze surface area for each cornea was calculated. Results: The mean epithelialization time was 47.25 hours in the control group, 45.00 hours in the SAHA group, and 43.50 hours in the pirfenidone group, revealing no significant difference (P = 0.368). The median difference in pixel intensity between haze and nonhaze areas was 21.5 in the control group, 8.0 in the SAHA group, and 8.0 in the pirfenidone group, which is significant (P < 0.01). The median haze surface area was 12.96 mm2 in the control group, 5.70 mm2 in the SAHA group, and 5.92 mm2 in the pirfenidone group, which is significant (P < 0.01). Conclusions: Stromal-wounded ex vivo canine corneas exhibited greater optical clarity when treated with SAHA and pirfenidone than when placebo treated at 21 days. There was no significant difference in epithelialization rate between groups. Corneal contour was correlated with geographic haze distribution." @default.
- W2900820805 created "2018-11-29" @default.
- W2900820805 creator A5001286110 @default.
- W2900820805 creator A5023362908 @default.
- W2900820805 creator A5034045633 @default.
- W2900820805 creator A5047320885 @default.
- W2900820805 creator A5051560748 @default.
- W2900820805 creator A5057222593 @default.
- W2900820805 creator A5089145782 @default.
- W2900820805 date "2018-11-20" @default.
- W2900820805 modified "2023-10-10" @default.
- W2900820805 title "Assessment of Topical Therapies for Improving the Optical Clarity Following Stromal Wounding in a Novel Ex Vivo Canine Cornea Model" @default.
- W2900820805 cites W1493760002 @default.
- W2900820805 cites W1558385102 @default.
- W2900820805 cites W1605455787 @default.
- W2900820805 cites W1885351946 @default.
- W2900820805 cites W1925631427 @default.
- W2900820805 cites W1949741226 @default.
- W2900820805 cites W1964192210 @default.
- W2900820805 cites W1969709292 @default.
- W2900820805 cites W1974344663 @default.
- W2900820805 cites W1989200736 @default.
- W2900820805 cites W1989591249 @default.
- W2900820805 cites W1990547143 @default.
- W2900820805 cites W1996141260 @default.
- W2900820805 cites W2002165043 @default.
- W2900820805 cites W2002241209 @default.
- W2900820805 cites W2007666439 @default.
- W2900820805 cites W2008716980 @default.
- W2900820805 cites W2010779479 @default.
- W2900820805 cites W2013361987 @default.
- W2900820805 cites W2014067185 @default.
- W2900820805 cites W2015851393 @default.
- W2900820805 cites W2018009819 @default.
- W2900820805 cites W2020688772 @default.
- W2900820805 cites W2021069818 @default.
- W2900820805 cites W2024966180 @default.
- W2900820805 cites W2025430092 @default.
- W2900820805 cites W2026381584 @default.
- W2900820805 cites W2028643690 @default.
- W2900820805 cites W2030028523 @default.
- W2900820805 cites W2030145184 @default.
- W2900820805 cites W2030837762 @default.
- W2900820805 cites W2033724586 @default.
- W2900820805 cites W2037250064 @default.
- W2900820805 cites W2041492303 @default.
- W2900820805 cites W2048399704 @default.
- W2900820805 cites W2052321296 @default.
- W2900820805 cites W2052485885 @default.
- W2900820805 cites W2055605421 @default.
- W2900820805 cites W2059489068 @default.
- W2900820805 cites W2060112842 @default.
- W2900820805 cites W2062387633 @default.
- W2900820805 cites W2065987595 @default.
- W2900820805 cites W2068947136 @default.
- W2900820805 cites W2070433411 @default.
- W2900820805 cites W2071115015 @default.
- W2900820805 cites W2071362471 @default.
- W2900820805 cites W2072524138 @default.
- W2900820805 cites W2085604666 @default.
- W2900820805 cites W2086432076 @default.
- W2900820805 cites W2088876699 @default.
- W2900820805 cites W2089713875 @default.
- W2900820805 cites W2091120910 @default.
- W2900820805 cites W2101548854 @default.
- W2900820805 cites W2102169774 @default.
- W2900820805 cites W2107277218 @default.
- W2900820805 cites W2122808924 @default.
- W2900820805 cites W2135619784 @default.
- W2900820805 cites W2135863640 @default.
- W2900820805 cites W2140421916 @default.
- W2900820805 cites W2147768158 @default.
- W2900820805 cites W2156956504 @default.
- W2900820805 cites W2157429545 @default.
- W2900820805 cites W2162772085 @default.
- W2900820805 cites W2167273009 @default.
- W2900820805 cites W2172043646 @default.
- W2900820805 cites W2219429396 @default.
- W2900820805 cites W2257714393 @default.
- W2900820805 cites W2321852657 @default.
- W2900820805 cites W2326492036 @default.
- W2900820805 cites W2534063678 @default.
- W2900820805 cites W2564178166 @default.
- W2900820805 cites W2600771186 @default.
- W2900820805 cites W2612180325 @default.
- W2900820805 cites W2612893883 @default.
- W2900820805 cites W2625985824 @default.
- W2900820805 cites W2794494454 @default.
- W2900820805 cites W4211075966 @default.
- W2900820805 cites W4247255054 @default.
- W2900820805 cites W4313777 @default.
- W2900820805 doi "https://doi.org/10.1167/iovs.17-23085" @default.
- W2900820805 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30658034" @default.
- W2900820805 hasPublicationYear "2018" @default.
- W2900820805 type Work @default.
- W2900820805 sameAs 2900820805 @default.
- W2900820805 citedByCount "15" @default.
- W2900820805 countsByYear W29008208052020 @default.