Matches in SemOpenAlex for { <https://semopenalex.org/work/W2900839972> ?p ?o ?g. }
- W2900839972 abstract "Abstract Abdominal adhesions (AA) account for the most common complication of peritoneal surgery with bowel obstruction being the severest problem in the absence of effective predicting biomarkers. Anti-AA-barriers or adhesiolysis did not completely prevent bowel obstruction, although there is evidence they might reduce related complications requiring reoperation. In addition, gender-related predispositions have not been adequately investigated. We explored the role of coagulation Factor XIII ( F13A1 and F13B subunit-genes) in patients following laparotomy, mostly median/lower median incision line. Globally, 426 patients (54%,♀), were PCR-SNP-genotyped for FXIIIA V34L (rs5985), FXIIIA P564L (rs5982), FXIIIA Y204F (rs3024477) and FXIIIB H95R (rs6003). Patients’ clinical phenotypes were: Group-A (n = 212), those who developed AA, and 55.2% of them developed bowel obstruction (subgroup-A1), the remaining were subgroup-A2; Group B (n = 214) were those who did not develop AA (subgroup-B1; 53.3%) or symptoms/complications (subgroup-B2). Among different laparotomy, colon surgery associated with AA at a major extent (OR = 5.1; 3.24–7.8; P < 0.0001) with different gender scores (♀OR = 5.33; 2.32–12.23; P < 0.0001 and ♂OR = 3.44; 1.58–7.49; P < 0.0001). Among SNPs, P564L (OR = 4.42; 1.45–13.4; P = 0.008) and Y204F (OR = 7.78; 1.62–37.3; P = 0.01) significantly predicted bowel obstruction and survival-analyses yielded interesting gender distinctions (♀HR = 5.28; 2.36–11.8; P = 0.00005; ♂HR = 2.22; 1.31–3.85; P = 0.0034). Active compounds preventing AA belong to the anticoagulant/fibrinolysis areas, suggesting them candidate investigation targets. We identified novel prognostic markers to predict AA/bowel obstruction giving insights to design novel therapeutic and gender prevention programs." @default.
- W2900839972 created "2018-11-29" @default.
- W2900839972 creator A5000905886 @default.
- W2900839972 creator A5007696472 @default.
- W2900839972 creator A5015378696 @default.
- W2900839972 creator A5042887836 @default.
- W2900839972 creator A5047223531 @default.
- W2900839972 creator A5071494198 @default.
- W2900839972 creator A5075204695 @default.
- W2900839972 creator A5082312639 @default.
- W2900839972 creator A5091130945 @default.
- W2900839972 date "2018-11-16" @default.
- W2900839972 modified "2023-10-16" @default.
- W2900839972 title "Inherited genetic predispositions in F13A1 and F13B genes predict abdominal adhesion formation: identification of gender prognostic indicators" @default.
- W2900839972 cites W133043211 @default.
- W2900839972 cites W133048606 @default.
- W2900839972 cites W1438919521 @default.
- W2900839972 cites W1792637460 @default.
- W2900839972 cites W1966806270 @default.
- W2900839972 cites W1980527619 @default.
- W2900839972 cites W1981142644 @default.
- W2900839972 cites W1981997914 @default.
- W2900839972 cites W1984601090 @default.
- W2900839972 cites W1990444805 @default.
- W2900839972 cites W1991409739 @default.
- W2900839972 cites W1994925063 @default.
- W2900839972 cites W1995133466 @default.
- W2900839972 cites W2005022514 @default.
- W2900839972 cites W2007703345 @default.
- W2900839972 cites W2008778245 @default.
- W2900839972 cites W2011462820 @default.
- W2900839972 cites W2039758624 @default.
- W2900839972 cites W2040287039 @default.
- W2900839972 cites W2041460340 @default.
- W2900839972 cites W2050941530 @default.
- W2900839972 cites W2055889917 @default.
- W2900839972 cites W2070495303 @default.
- W2900839972 cites W2076466056 @default.
- W2900839972 cites W2084337527 @default.
- W2900839972 cites W2084768685 @default.
- W2900839972 cites W2088738897 @default.
- W2900839972 cites W2102332869 @default.
- W2900839972 cites W2104365341 @default.
- W2900839972 cites W2109744772 @default.
- W2900839972 cites W2109748369 @default.
- W2900839972 cites W2110582342 @default.
- W2900839972 cites W2116980521 @default.
- W2900839972 cites W2119329939 @default.
- W2900839972 cites W2125341984 @default.
- W2900839972 cites W2126897207 @default.
- W2900839972 cites W2129371899 @default.
- W2900839972 cites W2138924447 @default.
- W2900839972 cites W2154410358 @default.
- W2900839972 cites W2159504493 @default.
- W2900839972 cites W2293662776 @default.
- W2900839972 cites W2471214060 @default.
- W2900839972 cites W2474287307 @default.
- W2900839972 cites W2593318548 @default.
- W2900839972 cites W2771501673 @default.
- W2900839972 cites W2791653959 @default.
- W2900839972 cites W2891194747 @default.
- W2900839972 cites W4298081676 @default.
- W2900839972 cites W746280716 @default.
- W2900839972 doi "https://doi.org/10.1038/s41598-018-35185-x" @default.
- W2900839972 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6240050" @default.
- W2900839972 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30446716" @default.
- W2900839972 hasPublicationYear "2018" @default.
- W2900839972 type Work @default.
- W2900839972 sameAs 2900839972 @default.
- W2900839972 citedByCount "12" @default.
- W2900839972 countsByYear W29008399722019 @default.
- W2900839972 countsByYear W29008399722020 @default.
- W2900839972 countsByYear W29008399722021 @default.
- W2900839972 countsByYear W29008399722023 @default.
- W2900839972 crossrefType "journal-article" @default.
- W2900839972 hasAuthorship W2900839972A5000905886 @default.
- W2900839972 hasAuthorship W2900839972A5007696472 @default.
- W2900839972 hasAuthorship W2900839972A5015378696 @default.
- W2900839972 hasAuthorship W2900839972A5042887836 @default.
- W2900839972 hasAuthorship W2900839972A5047223531 @default.
- W2900839972 hasAuthorship W2900839972A5071494198 @default.
- W2900839972 hasAuthorship W2900839972A5075204695 @default.
- W2900839972 hasAuthorship W2900839972A5082312639 @default.
- W2900839972 hasAuthorship W2900839972A5091130945 @default.
- W2900839972 hasBestOaLocation W29008399721 @default.
- W2900839972 hasConcept C104317684 @default.
- W2900839972 hasConcept C126322002 @default.
- W2900839972 hasConcept C135763542 @default.
- W2900839972 hasConcept C141071460 @default.
- W2900839972 hasConcept C153209595 @default.
- W2900839972 hasConcept C187960798 @default.
- W2900839972 hasConcept C2779036427 @default.
- W2900839972 hasConcept C2779672106 @default.
- W2900839972 hasConcept C2779787475 @default.
- W2900839972 hasConcept C2780778865 @default.
- W2900839972 hasConcept C44249647 @default.
- W2900839972 hasConcept C54355233 @default.
- W2900839972 hasConcept C71924100 @default.
- W2900839972 hasConcept C86803240 @default.
- W2900839972 hasConcept C90924648 @default.