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- W2900868416 abstract "Members of the Alphapapillomavirus genus are causative agents for cervix cancer and benign lesions in humans. These viruses are classified according to sequence similarities in their L1 region. Yet, viral carcinogenicity has been associated with variations in the proteins encoded by the E6 and E7 genes. In order to relate evolutionary history with origin of carcinogenicity, we performed phylogenetic reconstructions using both nucleotide and predicted amino acid sequences of the L1, E6 and E7 genes. Whilst phylogenetic analysis of L1 reconstructed genus evolutionary history, phylogenies based on E6 and E7 proteins support the idea that mutations at amino acids S/Tx [V/L] (E6) and LxCxE (E7) might be responsible for carcinogenic potential. These findings indicate that virulence within Alphapapillomavirus have appeared multiple times during evolution. Our results reveal that oncogenic potential is not a monophyletic clade-specific adaptation but might be the result of positive selection on random mutations occurring on proteins involved in host infection during viral diversification." @default.
- W2900868416 created "2018-11-29" @default.
- W2900868416 creator A5016596732 @default.
- W2900868416 creator A5051563999 @default.
- W2900868416 date "2019-01-01" @default.
- W2900868416 modified "2023-09-24" @default.
- W2900868416 title "Phylogenetic analysis of Alphapapillomavirus based on L1, E6 and E7 regions suggests that carcinogenicity and tissue tropism have appeared multiple times during viral evolution" @default.
- W2900868416 cites W140061535 @default.
- W2900868416 cites W1492665086 @default.
- W2900868416 cites W1501498790 @default.
- W2900868416 cites W1515226261 @default.
- W2900868416 cites W1526247840 @default.
- W2900868416 cites W1568135922 @default.
- W2900868416 cites W1568779676 @default.
- W2900868416 cites W157146037 @default.
- W2900868416 cites W1577885672 @default.
- W2900868416 cites W163257711 @default.
- W2900868416 cites W1802391258 @default.
- W2900868416 cites W1901126754 @default.
- W2900868416 cites W1969042907 @default.
- W2900868416 cites W1974452743 @default.
- W2900868416 cites W1975728570 @default.
- W2900868416 cites W1975785662 @default.
- W2900868416 cites W1976491544 @default.
- W2900868416 cites W1981444463 @default.
- W2900868416 cites W1984992908 @default.
- W2900868416 cites W1986960362 @default.
- W2900868416 cites W1987350137 @default.
- W2900868416 cites W1987616663 @default.
- W2900868416 cites W1994758270 @default.
- W2900868416 cites W2000647783 @default.
- W2900868416 cites W2001658434 @default.
- W2900868416 cites W2006708542 @default.
- W2900868416 cites W2007733233 @default.
- W2900868416 cites W2012086311 @default.
- W2900868416 cites W2014575224 @default.
- W2900868416 cites W2016000389 @default.
- W2900868416 cites W2017921754 @default.
- W2900868416 cites W2018646351 @default.
- W2900868416 cites W2019032222 @default.
- W2900868416 cites W2026617482 @default.
- W2900868416 cites W2026766776 @default.
- W2900868416 cites W2027561690 @default.
- W2900868416 cites W2030328951 @default.
- W2900868416 cites W2030735803 @default.
- W2900868416 cites W2036641307 @default.
- W2900868416 cites W2039382131 @default.
- W2900868416 cites W2039482985 @default.
- W2900868416 cites W2039934202 @default.
- W2900868416 cites W2047093839 @default.
- W2900868416 cites W2052489835 @default.
- W2900868416 cites W2059109849 @default.
- W2900868416 cites W2059658986 @default.
- W2900868416 cites W2060131263 @default.
- W2900868416 cites W2060386076 @default.
- W2900868416 cites W2063278125 @default.
- W2900868416 cites W2065150919 @default.
- W2900868416 cites W2065765062 @default.
- W2900868416 cites W2066540580 @default.
- W2900868416 cites W2068900157 @default.
- W2900868416 cites W2068991236 @default.
- W2900868416 cites W2070444077 @default.
- W2900868416 cites W2071827443 @default.
- W2900868416 cites W2073417582 @default.
- W2900868416 cites W2078066154 @default.
- W2900868416 cites W2078123210 @default.
- W2900868416 cites W2080246874 @default.
- W2900868416 cites W2086142703 @default.
- W2900868416 cites W2086993352 @default.
- W2900868416 cites W2090413996 @default.
- W2900868416 cites W2093710784 @default.
- W2900868416 cites W2097730814 @default.
- W2900868416 cites W2100599646 @default.
- W2900868416 cites W2100776514 @default.
- W2900868416 cites W2101196984 @default.
- W2900868416 cites W2101899141 @default.
- W2900868416 cites W2104176771 @default.
- W2900868416 cites W2109584764 @default.
- W2900868416 cites W2112859230 @default.
- W2900868416 cites W2112956791 @default.
- W2900868416 cites W2119900532 @default.
- W2900868416 cites W2120322137 @default.
- W2900868416 cites W2125079066 @default.
- W2900868416 cites W2127576059 @default.
- W2900868416 cites W2129687362 @default.
- W2900868416 cites W2132926880 @default.
- W2900868416 cites W2133437368 @default.
- W2900868416 cites W2134770844 @default.
- W2900868416 cites W2136797609 @default.
- W2900868416 cites W2136872570 @default.
- W2900868416 cites W2139134537 @default.
- W2900868416 cites W2139909539 @default.
- W2900868416 cites W2140059211 @default.
- W2900868416 cites W2143158562 @default.
- W2900868416 cites W2143297289 @default.
- W2900868416 cites W2145032328 @default.
- W2900868416 cites W2146058063 @default.
- W2900868416 cites W2148047088 @default.
- W2900868416 cites W2150270014 @default.
- W2900868416 cites W2151916134 @default.