FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2900870325> ?p ?o ?g. }

• W2900870325 endingPage "3649" @default.
• W2900870325 startingPage "3649" @default.
• W2900870325 abstract "Lactate is a metabolic substrate mainly produced in muscles, especially during exercise. Recently, it was reported that lactate affects myoblast differentiation; however, the obtained results are inconsistent and the in vivo effect of lactate remains unclear. Our study thus aimed to evaluate the effects of lactate on myogenic differentiation and its underlying mechanism. The differentiation of C2C12 murine myogenic cells was accelerated in the presence of lactate and, consequently, myotube hypertrophy was achieved. Gene expression analysis of myogenic regulatory factors showed significantly increased myogenic determination protein (MyoD) gene expression in lactate-treated cells compared with that in untreated ones. Moreover, lactate enhanced gene and protein expression of myosin heavy chain (MHC). In particular, lactate increased gene expression of specific MHC isotypes, MHCIIb and IId/x, in a dose-dependent manner. Using a reporter assay, we showed that lactate increased promoter activity of the MHCIIb gene and that a MyoD binding site in the promoter region was necessary for the lactate-induced increase in activity. Finally, peritoneal injection of lactate in mice resulted in enhanced regeneration and fiber hypertrophy in glycerol-induced regenerating muscles. In conclusion, physiologically high lactate concentrations modulated muscle differentiation by regulating MyoD-associated networks, thereby enhancing MHC expression and myotube hypertrophy in vitro and, potentially, in vivo." @default.
• W2900870325 created "2018-11-29" @default.
• W2900870325 creator A5004310644 @default.
• W2900870325 creator A5012775967 @default.
• W2900870325 creator A5029182190 @default.
• W2900870325 creator A5030863104 @default.
• W2900870325 creator A5043744936 @default.
• W2900870325 date "2018-11-19" @default.
• W2900870325 modified "2023-10-16" @default.
• W2900870325 title "Lactate Promotes Myoblast Differentiation and Myotube Hypertrophy via a Pathway Involving MyoD In Vitro and Enhances Muscle Regeneration In Vivo" @default.
• W2900870325 cites W1142031920 @default.
• W2900870325 cites W1506680557 @default.
• W2900870325 cites W1541458845 @default.
• W2900870325 cites W1605337130 @default.
• W2900870325 cites W1837450065 @default.
• W2900870325 cites W1870980090 @default.
• W2900870325 cites W1965911346 @default.
• W2900870325 cites W1968827129 @default.
• W2900870325 cites W1969826942 @default.
• W2900870325 cites W1969999230 @default.
• W2900870325 cites W1970287879 @default.
• W2900870325 cites W1971314280 @default.
• W2900870325 cites W1973764045 @default.
• W2900870325 cites W1974909493 @default.
• W2900870325 cites W1979533069 @default.
• W2900870325 cites W1986482362 @default.
• W2900870325 cites W1998521558 @default.
• W2900870325 cites W2011408286 @default.
• W2900870325 cites W2022223340 @default.
• W2900870325 cites W2027435060 @default.
• W2900870325 cites W2031458556 @default.
• W2900870325 cites W2035795689 @default.
• W2900870325 cites W2036145275 @default.
• W2900870325 cites W2044502027 @default.
• W2900870325 cites W2045593834 @default.
• W2900870325 cites W2050853454 @default.
• W2900870325 cites W2057868246 @default.
• W2900870325 cites W2062064489 @default.
• W2900870325 cites W2065363098 @default.
• W2900870325 cites W2069752613 @default.
• W2900870325 cites W2098438164 @default.
• W2900870325 cites W2102902846 @default.
• W2900870325 cites W2104492051 @default.
• W2900870325 cites W2104585093 @default.
• W2900870325 cites W2109154725 @default.
• W2900870325 cites W2130025116 @default.
• W2900870325 cites W2131466509 @default.
• W2900870325 cites W2139581284 @default.
• W2900870325 cites W2146822434 @default.
• W2900870325 cites W2148548585 @default.
• W2900870325 cites W2153235420 @default.
• W2900870325 cites W2153295233 @default.
• W2900870325 cites W2153594132 @default.
• W2900870325 cites W2154326737 @default.
• W2900870325 cites W2163785511 @default.
• W2900870325 cites W2165168186 @default.
• W2900870325 cites W2167062322 @default.
• W2900870325 cites W2169108031 @default.
• W2900870325 cites W2183104531 @default.
• W2900870325 cites W2281320311 @default.
• W2900870325 cites W2415143274 @default.
• W2900870325 cites W2517166961 @default.
• W2900870325 cites W2528335443 @default.
• W2900870325 cites W2554910891 @default.
• W2900870325 cites W2567010780 @default.
• W2900870325 cites W2611535218 @default.
• W2900870325 doi "https://doi.org/10.3390/ijms19113649" @default.
• W2900870325 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6274869" @default.
• W2900870325 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30463265" @default.
• W2900870325 hasPublicationYear "2018" @default.
• W2900870325 type Work @default.
• W2900870325 sameAs 2900870325 @default.
• W2900870325 citedByCount "38" @default.
• W2900870325 countsByYear W29008703252019 @default.
• W2900870325 countsByYear W29008703252020 @default.
• W2900870325 countsByYear W29008703252021 @default.
• W2900870325 countsByYear W29008703252022 @default.
• W2900870325 countsByYear W29008703252023 @default.
• W2900870325 crossrefType "journal-article" @default.
• W2900870325 hasAuthorship W2900870325A5004310644 @default.
• W2900870325 hasAuthorship W2900870325A5012775967 @default.
• W2900870325 hasAuthorship W2900870325A5029182190 @default.
• W2900870325 hasAuthorship W2900870325A5030863104 @default.
• W2900870325 hasAuthorship W2900870325A5043744936 @default.
• W2900870325 hasBestOaLocation W29008703251 @default.
• W2900870325 hasConcept C104317684 @default.
• W2900870325 hasConcept C134018914 @default.
• W2900870325 hasConcept C150194340 @default.
• W2900870325 hasConcept C153911025 @default.
• W2900870325 hasConcept C167414201 @default.
• W2900870325 hasConcept C207001950 @default.
• W2900870325 hasConcept C207200792 @default.
• W2900870325 hasConcept C2778106681 @default.
• W2900870325 hasConcept C2780508455 @default.
• W2900870325 hasConcept C2909166674 @default.
• W2900870325 hasConcept C3763915 @default.
• W2900870325 hasConcept C54355233 @default.
• W2900870325 hasConcept C55493867 @default.

• next