FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2900888964> ?p ?o ?g. }

• W2900888964 endingPage "563" @default.
• W2900888964 startingPage "551" @default.
• W2900888964 abstract "Exposure to ambient fine particular matter (PM2.5) has been clearly associated with male reproductive disorders. However, very limited toxicological studies were carried out to investigate the potential mechanisms underlying the PM2.5-induced sperm quality decline. In the present study, we established a real time whole-body PM2.5 exposure mouse model to investigate the effects of PM2.5 on sperm quality and its potential mechanisms. Sixty male C57BL/6 mice were randomly subjected to three groups: filtered air group, unfiltered air group and concentrated air group. Half of the mice from each group were sacrificed for study when the exposure duration accumulated to 8 weeks and the rest of the mice were sacrificed when exposed for 16 weeks. Our results suggested that PM2.5 exposure could induce significant increases in circulating white blood cells and inflammation in lungs. PM2.5 exposure induced apparently DNA damages and histopathologic changes in testes. There were significantly decreased sperm densities of mice, which were paralleled with the down-regulated testosterone levels in testes tissue of mice after exposure to PM2.5 for 16 weeks. The numbers of motile sperms were decreased and sperms with abnormal morphology were increased after PM2.5 exposure in a time-depended and dose-depended manner. PM2.5 exposure significantly increased the expression of the major components of the NACHT, LRR and PYD domains-containing protein3 (NALP3) inflammasome, accompanied by the increased expression of miR-183/96/182 targeting FOXO1 in testes. The present data demonstrated that sperm quality decline induced by PM2.5 could be partly explained by the inflammatory reaction in testes which might be a consequence of systemic inflammation. The molecular mechanism was depended on the activation of NALP3 inflammasome accompanied by miR-183/96/182 targeting FOXO1 in testes." @default.
• W2900888964 created "2018-11-29" @default.
• W2900888964 creator A5017052171 @default.
• W2900888964 creator A5018833932 @default.
• W2900888964 creator A5032207611 @default.
• W2900888964 creator A5032447166 @default.
• W2900888964 creator A5054418515 @default.
• W2900888964 creator A5060778724 @default.
• W2900888964 creator A5066397257 @default.
• W2900888964 creator A5083967189 @default.
• W2900888964 creator A5084015541 @default.
• W2900888964 creator A5085643062 @default.
• W2900888964 creator A5090548569 @default.
• W2900888964 date "2019-03-01" @default.
• W2900888964 modified "2023-10-17" @default.
• W2900888964 title "PM2.5 exposure impairs sperm quality through testicular damage dependent on NALP3 inflammasome and miR-183/96/182 cluster targeting FOXO1 in mouse" @default.
• W2900888964 cites W1492783417 @default.
• W2900888964 cites W1832109775 @default.
• W2900888964 cites W1920369975 @default.
• W2900888964 cites W1932718020 @default.
• W2900888964 cites W1969544207 @default.
• W2900888964 cites W1975104934 @default.
• W2900888964 cites W1975295762 @default.
• W2900888964 cites W1977183031 @default.
• W2900888964 cites W1991122771 @default.
• W2900888964 cites W1993488176 @default.
• W2900888964 cites W2001128997 @default.
• W2900888964 cites W2008410610 @default.
• W2900888964 cites W2012442548 @default.
• W2900888964 cites W2016222254 @default.
• W2900888964 cites W2027586930 @default.
• W2900888964 cites W2029401079 @default.
• W2900888964 cites W2029544901 @default.
• W2900888964 cites W2038764227 @default.
• W2900888964 cites W2043851579 @default.
• W2900888964 cites W2066148159 @default.
• W2900888964 cites W2071766782 @default.
• W2900888964 cites W2075828127 @default.
• W2900888964 cites W2081086234 @default.
• W2900888964 cites W2085229702 @default.
• W2900888964 cites W2094778506 @default.
• W2900888964 cites W2095998027 @default.
• W2900888964 cites W2097698413 @default.
• W2900888964 cites W2098845312 @default.
• W2900888964 cites W2118918019 @default.
• W2900888964 cites W2128903550 @default.
• W2900888964 cites W2129838866 @default.
• W2900888964 cites W2137604894 @default.
• W2900888964 cites W2143704513 @default.
• W2900888964 cites W2152657820 @default.
• W2900888964 cites W2155738620 @default.
• W2900888964 cites W2161852954 @default.
• W2900888964 cites W2199403026 @default.
• W2900888964 cites W2256720831 @default.
• W2900888964 cites W2338096019 @default.
• W2900888964 cites W2399730297 @default.
• W2900888964 cites W2404035599 @default.
• W2900888964 cites W2410299164 @default.
• W2900888964 cites W2415476785 @default.
• W2900888964 cites W2461586262 @default.
• W2900888964 cites W2464468902 @default.
• W2900888964 cites W2467558113 @default.
• W2900888964 cites W2468973154 @default.
• W2900888964 cites W2495367231 @default.
• W2900888964 cites W2513644890 @default.
• W2900888964 cites W2563993762 @default.
• W2900888964 cites W2566077529 @default.
• W2900888964 cites W2597759765 @default.
• W2900888964 cites W26653565 @default.
• W2900888964 cites W2727157783 @default.
• W2900888964 cites W2754313926 @default.
• W2900888964 cites W2762472682 @default.
• W2900888964 cites W2768004339 @default.
• W2900888964 cites W2768671952 @default.
• W2900888964 cites W2768967814 @default.
• W2900888964 cites W2769314384 @default.
• W2900888964 cites W2781022250 @default.
• W2900888964 cites W2782578484 @default.
• W2900888964 cites W2792750014 @default.
• W2900888964 cites W2793204952 @default.
• W2900888964 cites W2799661725 @default.
• W2900888964 cites W2803555380 @default.
• W2900888964 cites W2805357125 @default.
• W2900888964 cites W2809783517 @default.
• W2900888964 cites W4241402638 @default.
• W2900888964 doi "https://doi.org/10.1016/j.ecoenv.2018.10.108" @default.
• W2900888964 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30476817" @default.
• W2900888964 hasPublicationYear "2019" @default.
• W2900888964 type Work @default.
• W2900888964 sameAs 2900888964 @default.
• W2900888964 citedByCount "70" @default.
• W2900888964 countsByYear W29008889642019 @default.
• W2900888964 countsByYear W29008889642020 @default.
• W2900888964 countsByYear W29008889642021 @default.
• W2900888964 countsByYear W29008889642022 @default.
• W2900888964 countsByYear W29008889642023 @default.
• W2900888964 crossrefType "journal-article" @default.
• W2900888964 hasAuthorship W2900888964A5017052171 @default.

• next