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- W2900897976 abstract "Glycoprotein D (gD) of herpes simplex virus type 1 (HSV-1) plays a key role in multiple events during infection including virus entry, cell-to-cell spread, and virus-induced syncytia formation. Here, we provide evidence that an arginine/lysine cluster located at the transmembrane-cytoplasm interface of gD critically contributes to viral spread and cell-cell fusion. Our studies began with the discovery that packaging of gD into virions is almost completely blocked in the absence of tegument protein UL16. We subsequently identified a novel, direct, and regulated interaction between UL16 and gD, but this was not important for syncytia formation. However, a mutational analysis of the membrane-proximal basic residues of gD revealed that they are needed for the gBsyn phenotype, salubrinal-induced fusion of HSV-infected cells, and cell-to-cell spread. Finally, we found that these same gD tail basic residues are not required for cell fusion induced by a gKsyn variant." @default.
- W2900897976 created "2018-11-29" @default.
- W2900897976 creator A5021110484 @default.
- W2900897976 creator A5024391758 @default.
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- W2900897976 creator A5083185087 @default.
- W2900897976 creator A5086559201 @default.
- W2900897976 creator A5091826270 @default.
- W2900897976 date "2019-01-01" @default.
- W2900897976 modified "2023-10-18" @default.
- W2900897976 title "Glycoprotein D of HSV-1 is dependent on tegument protein UL16 for packaging and contains a motif that is differentially required for syncytia formation" @default.
- W2900897976 cites W1498670035 @default.
- W2900897976 cites W1502427113 @default.
- W2900897976 cites W1560841381 @default.
- W2900897976 cites W1695142101 @default.
- W2900897976 cites W1747014860 @default.
- W2900897976 cites W1919588248 @default.
- W2900897976 cites W1963690535 @default.
- W2900897976 cites W1964419190 @default.
- W2900897976 cites W1966885880 @default.
- W2900897976 cites W1990538398 @default.
- W2900897976 cites W1990581911 @default.
- W2900897976 cites W1997221411 @default.
- W2900897976 cites W2001203782 @default.
- W2900897976 cites W2001371234 @default.
- W2900897976 cites W2017967782 @default.
- W2900897976 cites W2022667827 @default.
- W2900897976 cites W2023863923 @default.
- W2900897976 cites W2025962934 @default.
- W2900897976 cites W2031689797 @default.
- W2900897976 cites W2034996626 @default.
- W2900897976 cites W2036839993 @default.
- W2900897976 cites W2036935877 @default.
- W2900897976 cites W2038650325 @default.
- W2900897976 cites W2039106758 @default.
- W2900897976 cites W2040427472 @default.
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- W2900897976 cites W2054277844 @default.
- W2900897976 cites W2059686897 @default.
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- W2900897976 cites W2064421567 @default.
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- W2900897976 cites W2083016901 @default.
- W2900897976 cites W2085390874 @default.
- W2900897976 cites W2086687080 @default.
- W2900897976 cites W2090644748 @default.
- W2900897976 cites W2090942794 @default.
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- W2900897976 cites W2104643568 @default.
- W2900897976 cites W2105888501 @default.
- W2900897976 cites W2106961341 @default.
- W2900897976 cites W2108859569 @default.
- W2900897976 cites W2109168863 @default.
- W2900897976 cites W2109241375 @default.
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- W2900897976 cites W2119700881 @default.
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- W2900897976 cites W2123193533 @default.
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- W2900897976 cites W2137186878 @default.
- W2900897976 cites W2140487984 @default.
- W2900897976 cites W2144324042 @default.
- W2900897976 cites W2148173142 @default.
- W2900897976 cites W2148805755 @default.
- W2900897976 cites W2149227633 @default.
- W2900897976 cites W2149228676 @default.
- W2900897976 cites W2150441957 @default.
- W2900897976 cites W2152863327 @default.
- W2900897976 cites W2153610525 @default.
- W2900897976 cites W2155026265 @default.
- W2900897976 cites W2162014345 @default.
- W2900897976 cites W2163314480 @default.
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- W2900897976 cites W2165065699 @default.
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- W2900897976 cites W2169191388 @default.
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- W2900897976 cites W2301932608 @default.
- W2900897976 cites W2515033424 @default.
- W2900897976 cites W2744549795 @default.
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- W2900897976 doi "https://doi.org/10.1016/j.virol.2018.09.018" @default.
- W2900897976 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6400489" @default.
- W2900897976 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30465930" @default.
- W2900897976 hasPublicationYear "2019" @default.
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