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• W2900898495 abstract "Cystic fibrosis, hereditary hemochromatosis and palmar fibromatosis are often described as Celtic, based on their contemporary prevalence. The former two are among genetically defined disorders that seem to provide survival advantages to heterozygote individuals, while severe health problems happen in homozygote mutation carriers. Although palmar fibromatosis has no defined mutations, its prevalence has been linked to the prevalence of Y-Chromosome Haplogroup I that expanded after the Last Ice Age, thus making th distribution of all three Celtic diseases dependent on the global climate from 40 to 8 Kya. During the Last Ice Age, the global climate was dry and dark due to dust-laden atmosphere (20-25 times more than today). It has been postulated that skin pigmentation was related to insolation, UV protection and skin synthesis of vitamin D, so when our ancestors moved to Eurasia, individuals with pale skin became advantageous. Deficiency of vitamin D has several health consequences and some of them have been proposed by other authors as important for the spreading of cystic fibrosis mutations: rickets/osteomalacia; susceptibility to diarrheal diseases and tuberculosis and salt induced arterial hypertension. The here proposed link is between vitamin D deficiency and the anaemia of chronic disease that might have facilitated spreading of the hemochromatosis mutation. It seems plausible that the risk of health problems in the offspring of close relatives might have resulted in social taboos of consanguinity in Eurasian protosocieties. Ancient steam bath rituals seem linked to lower incidences of cystic fibrosis in several European populations, thus suggesting health protection in an arid, dusty climate of the last glaciation, that made CFTR mutations in heterozygote carriers less advantageous." @default.
• W2900898495 created "2018-11-29" @default.
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• W2900898495 date "2019-01-01" @default.
• W2900898495 modified "2023-09-26" @default.
• W2900898495 title "Was the Last Ice Age dusty climate instrumental in spreading of the three “Celtic” diseases (hemochromatosis, cystic fibrosis and palmar fibromatosis)?" @default.
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• W2900898495 doi "https://doi.org/10.1016/j.mehy.2018.11.006" @default.
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