FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2900898855> ?p ?o ?g. }

• W2900898855 endingPage "53" @default.
• W2900898855 startingPage "43" @default.
• W2900898855 abstract "The mechanisms of membrane defence by lysylphosphatidylglycerol (LPG), were investigated using synthetic biomimetic mono- and bilayer models of methicillin resistant S. aureus ST239 TW, based on its lipid composition in both pH 7.4 (28% LPG) and pH 5.5 (51% LPG) cultures. These models incorporated a stable synthetic analogue of LPG (3adLPG) to facilitate long-duration biophysical studies, which were previously limited by the lability native LPG. Both increased 3adLPG content and full headgroup ionization at pH 5.5, increased bilayer order and dampened overall charge, via the formation of neutral ion pairs with anionic lipids. Ion pair formation in air/liquid interface lipid monolayers elicited a significant condensing effect, which correlated with the inhibition of subphase-injected magainin 2 F5W partitioning. In fluid phase lipid vesicles, increasing the proportion of 3adLPG from 28 to 51 mol% completely inhibited the adoption of the membrane-active α‑helical conformation of the peptide, without the need for full headgroup ionization. Neutron reflectivity measurements performed on biomimetic PG/3adLPG fluid floating bilayers, showed a significant ordering effect of mild acidity on a bilayer containing 30 mol% 3adLPG, whilst peptide binding/partitioning was only fully inhibited in a bilayer with 55 mol% 3adLPG at pH 5.5. These findings are discussed with respect to the roles of LPG in resistance to human epithelial defences in S. aureus and the continued evolution of this opportunistic pathogen's virulence." @default.
• W2900898855 created "2018-11-29" @default.
• W2900898855 creator A5000209954 @default.
• W2900898855 creator A5030009896 @default.
• W2900898855 creator A5060504922 @default.
• W2900898855 creator A5075639856 @default.
• W2900898855 creator A5081948538 @default.
• W2900898855 date "2019-02-01" @default.
• W2900898855 modified "2023-10-11" @default.
• W2900898855 title "The pH-dependence of lipid-mediated antimicrobial peptide resistance in a model staphylococcal plasma membrane: A two-for-one mechanism of epithelial defence circumvention" @default.
• W2900898855 cites W1423300235 @default.
• W2900898855 cites W1491362469 @default.
• W2900898855 cites W1592671512 @default.
• W2900898855 cites W1597808068 @default.
• W2900898855 cites W1606415723 @default.
• W2900898855 cites W1910093388 @default.
• W2900898855 cites W1972667216 @default.
• W2900898855 cites W1986571558 @default.
• W2900898855 cites W1986645374 @default.
• W2900898855 cites W1990233153 @default.
• W2900898855 cites W1996197671 @default.
• W2900898855 cites W2004412941 @default.
• W2900898855 cites W2011641921 @default.
• W2900898855 cites W2016945141 @default.
• W2900898855 cites W2016960960 @default.
• W2900898855 cites W2019526697 @default.
• W2900898855 cites W2024437960 @default.
• W2900898855 cites W2026113709 @default.
• W2900898855 cites W2031189675 @default.
• W2900898855 cites W2038628700 @default.
• W2900898855 cites W2055073256 @default.
• W2900898855 cites W2063775095 @default.
• W2900898855 cites W2069864951 @default.
• W2900898855 cites W2070154306 @default.
• W2900898855 cites W2071572118 @default.
• W2900898855 cites W2074989047 @default.
• W2900898855 cites W2076257060 @default.
• W2900898855 cites W2094036261 @default.
• W2900898855 cites W2098533519 @default.
• W2900898855 cites W2124749002 @default.
• W2900898855 cites W2131044290 @default.
• W2900898855 cites W2142703076 @default.
• W2900898855 cites W2145684516 @default.
• W2900898855 cites W2148954461 @default.
• W2900898855 cites W2156343873 @default.
• W2900898855 cites W2157490360 @default.
• W2900898855 cites W2166791780 @default.
• W2900898855 cites W2171544481 @default.
• W2900898855 cites W2344750051 @default.
• W2900898855 cites W2537852878 @default.
• W2900898855 cites W2560185751 @default.
• W2900898855 cites W2590317180 @default.
• W2900898855 cites W2672496435 @default.
• W2900898855 cites W2767971816 @default.
• W2900898855 cites W2767984528 @default.
• W2900898855 cites W2781152936 @default.
• W2900898855 cites W2788563726 @default.
• W2900898855 cites W2802972673 @default.
• W2900898855 cites W2804323300 @default.
• W2900898855 cites W4210952504 @default.
• W2900898855 doi "https://doi.org/10.1016/j.ejps.2018.11.017" @default.
• W2900898855 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30471412" @default.
• W2900898855 hasPublicationYear "2019" @default.
• W2900898855 type Work @default.
• W2900898855 sameAs 2900898855 @default.
• W2900898855 citedByCount "7" @default.
• W2900898855 countsByYear W29008988552019 @default.
• W2900898855 countsByYear W29008988552020 @default.
• W2900898855 countsByYear W29008988552021 @default.
• W2900898855 countsByYear W29008988552022 @default.
• W2900898855 crossrefType "journal-article" @default.
• W2900898855 hasAuthorship W2900898855A5000209954 @default.
• W2900898855 hasAuthorship W2900898855A5030009896 @default.
• W2900898855 hasAuthorship W2900898855A5060504922 @default.
• W2900898855 hasAuthorship W2900898855A5075639856 @default.
• W2900898855 hasAuthorship W2900898855A5081948538 @default.
• W2900898855 hasBestOaLocation W29008988552 @default.
• W2900898855 hasConcept C103038307 @default.
• W2900898855 hasConcept C12554922 @default.
• W2900898855 hasConcept C130316041 @default.
• W2900898855 hasConcept C149997192 @default.
• W2900898855 hasConcept C185592680 @default.
• W2900898855 hasConcept C192157962 @default.
• W2900898855 hasConcept C2778553168 @default.
• W2900898855 hasConcept C2779281246 @default.
• W2900898855 hasConcept C39944091 @default.
• W2900898855 hasConcept C41625074 @default.
• W2900898855 hasConcept C43617362 @default.
• W2900898855 hasConcept C540938839 @default.
• W2900898855 hasConcept C55493867 @default.
• W2900898855 hasConcept C86803240 @default.
• W2900898855 hasConceptScore W2900898855C103038307 @default.
• W2900898855 hasConceptScore W2900898855C12554922 @default.
• W2900898855 hasConceptScore W2900898855C130316041 @default.
• W2900898855 hasConceptScore W2900898855C149997192 @default.
• W2900898855 hasConceptScore W2900898855C185592680 @default.
• W2900898855 hasConceptScore W2900898855C192157962 @default.
• W2900898855 hasConceptScore W2900898855C2778553168 @default.

• next