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- W2900907732 abstract "The indigenous inhabitants of Siberia live in some of the harshest environments on earth, experiencing extended periods of severe cold temperatures, dramatic variation in photoperiod, and limited and highly variable food resources. While the successful long-term settlement of this area by humans required multiple behavioral and cultural innovations, the nature of the underlying genetic changes has generally remained elusive. In this study, we used a three-part approach to identify putative targets of positive natural selection in Siberians. We first performed selection scans on whole exome and genome-wide single nucleotide polymorphism array data from multiple Siberian populations. We then annotated candidates in the tails of the empirical distributions, focusing on candidates with evidence linking them to biological processes and phenotypes previously identified as relevant to adaptation in circumpolar groups. The top candidates were then genotyped in additional populations to determine their spatial allele frequency distributions and associations with climate variables. Our analysis reveals missense mutations in three genes involved in lipid metabolism (PLA2G2A, PLIN1, and ANGPTL8) that exhibit genomic and spatial patterns consistent with selection for cold climate and/or diet. These variants are unified by their connection to brown adipose tissue and may help to explain previously observed physiological differences in Siberians such as low serum lipid levels and increased basal metabolic rate. These results support the hypothesis that indigenous Siberians have genetically adapted to their local environment by selection on multiple genes." @default.
- W2900907732 created "2018-11-29" @default.
- W2900907732 creator A5006007183 @default.
- W2900907732 creator A5022307816 @default.
- W2900907732 creator A5050150990 @default.
- W2900907732 creator A5064303756 @default.
- W2900907732 creator A5065192612 @default.
- W2900907732 creator A5076190364 @default.
- W2900907732 date "2018-11-14" @default.
- W2900907732 modified "2023-10-12" @default.
- W2900907732 title "Genomic Evidence of Local Adaptation to Climate and Diet in Indigenous Siberians" @default.
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