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- W2900930361 endingPage "535" @default.
- W2900930361 startingPage "522" @default.
- W2900930361 abstract "Cancer, a life threatening disease adversely affects huge population worldwide. Naturally derived drug discovery has emerged as a potential pathway in search of anticancers. Natural products-based drugs are generally considered safe, compared to their synthetic counterparts. A systematic review on adverse drugs reactions (ADRs) of the anticancer natural products has not been performed till date. We reviewed anticancer drugs, derived from plants, microbes and marine sources with their mechanistic action and reported ADRs. PubMed, ScienceDirect and Scopus were searched through Boolean information retrieval method using keywords “natural products”, “cancer”, “herbal”, “marine drugs” and “adverse drug reaction”. We documented ADRs of natural products based anticancer agents, mechanisms of action and chemical structures. It was observed that majority of the natural products based anticancer drugs possess ample adverse effects, dominantly hematological toxicities, alopecia, neurotoxicity and cardiotoxicity. These findings deviate from the preconceived notion about safer nature of herbal drugs. We also came across some anti-cancer natural products with less/no reported adverse events like Cabazitaxel and Arglabin. Comprehensive pharmacovigilance studies are needed to report ADRs and thereby predicting safety of anti-cancer drugs, either originated from natural sources or chemically synthesized." @default.
- W2900930361 created "2018-11-29" @default.
- W2900930361 creator A5011769386 @default.
- W2900930361 creator A5064278147 @default.
- W2900930361 creator A5081890143 @default.
- W2900930361 date "2019-01-01" @default.
- W2900930361 modified "2023-10-17" @default.
- W2900930361 title "Adverse drug reactions of anticancer drugs derived from natural sources" @default.
- W2900930361 cites W1487878063 @default.
- W2900930361 cites W1504523189 @default.
- W2900930361 cites W1536538430 @default.
- W2900930361 cites W1543790510 @default.
- W2900930361 cites W1598771823 @default.
- W2900930361 cites W1918288161 @default.
- W2900930361 cites W1935541780 @default.
- W2900930361 cites W1963569255 @default.
- W2900930361 cites W1964263217 @default.
- W2900930361 cites W1965694039 @default.
- W2900930361 cites W1968151389 @default.
- W2900930361 cites W1969879564 @default.
- W2900930361 cites W1970169669 @default.
- W2900930361 cites W1971687526 @default.
- W2900930361 cites W1974517960 @default.
- W2900930361 cites W1974842306 @default.
- W2900930361 cites W1979684056 @default.
- W2900930361 cites W1980998274 @default.
- W2900930361 cites W1982692072 @default.
- W2900930361 cites W1982728268 @default.
- W2900930361 cites W1990794637 @default.
- W2900930361 cites W1991743074 @default.
- W2900930361 cites W1992084711 @default.
- W2900930361 cites W1992716708 @default.
- W2900930361 cites W1996486246 @default.
- W2900930361 cites W1999683540 @default.
- W2900930361 cites W2000129278 @default.
- W2900930361 cites W2002831254 @default.
- W2900930361 cites W2004457388 @default.
- W2900930361 cites W2009956307 @default.
- W2900930361 cites W2012889532 @default.
- W2900930361 cites W2014077191 @default.
- W2900930361 cites W2016925709 @default.
- W2900930361 cites W2018489324 @default.
- W2900930361 cites W2018563247 @default.
- W2900930361 cites W2018976898 @default.
- W2900930361 cites W2020709442 @default.
- W2900930361 cites W2021520631 @default.
- W2900930361 cites W2026122666 @default.
- W2900930361 cites W2027742171 @default.
- W2900930361 cites W2028101098 @default.
- W2900930361 cites W2030224115 @default.
- W2900930361 cites W2033588393 @default.
- W2900930361 cites W2033801159 @default.
- W2900930361 cites W2036371533 @default.
- W2900930361 cites W2040703648 @default.
- W2900930361 cites W2040785900 @default.
- W2900930361 cites W2041155215 @default.
- W2900930361 cites W2042087938 @default.
- W2900930361 cites W2044358936 @default.
- W2900930361 cites W2045926738 @default.
- W2900930361 cites W2048462280 @default.
- W2900930361 cites W2049658833 @default.
- W2900930361 cites W2056446966 @default.
- W2900930361 cites W2059767336 @default.
- W2900930361 cites W2059996228 @default.
- W2900930361 cites W2060275913 @default.
- W2900930361 cites W2060818162 @default.
- W2900930361 cites W2061843008 @default.
- W2900930361 cites W2064073012 @default.
- W2900930361 cites W2064661601 @default.
- W2900930361 cites W2066101111 @default.
- W2900930361 cites W2067361585 @default.
- W2900930361 cites W2068304807 @default.
- W2900930361 cites W2069308265 @default.
- W2900930361 cites W2069433719 @default.
- W2900930361 cites W2076088849 @default.
- W2900930361 cites W2078977301 @default.
- W2900930361 cites W2079678302 @default.
- W2900930361 cites W2082799445 @default.
- W2900930361 cites W2083126023 @default.
- W2900930361 cites W2085715760 @default.
- W2900930361 cites W2086078595 @default.
- W2900930361 cites W2088226047 @default.
- W2900930361 cites W2088432253 @default.
- W2900930361 cites W2095424411 @default.
- W2900930361 cites W2097290405 @default.
- W2900930361 cites W2101090208 @default.
- W2900930361 cites W2101770250 @default.
- W2900930361 cites W2103916895 @default.
- W2900930361 cites W2110663171 @default.
- W2900930361 cites W2111309259 @default.
- W2900930361 cites W2112200517 @default.
- W2900930361 cites W2114282601 @default.
- W2900930361 cites W2118877816 @default.
- W2900930361 cites W2118881636 @default.
- W2900930361 cites W2123851255 @default.
- W2900930361 cites W2127912482 @default.
- W2900930361 cites W2128403792 @default.
- W2900930361 cites W2137512719 @default.