FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2900936706> ?p ?o ?g. }

• W2900936706 endingPage "152763" @default.
• W2900936706 startingPage "152763" @default.
• W2900936706 abstract "Hypericum perforatum is used in ethnopharmacology and has recently become popular in conventional medicine for treatment of mild to moderate depression. The abundance of potentially functional phytochemicals and their broader utilizations in traditional medicine suggests that ingestion of H. perforatum may impart additional secondary health benefits.Considering that many phytochemicals are known to display antioxidant activity, it was hypothesized that H. perforatum ingestion may inhibit oxidative stress and inflammation (OSI) which occurs in transient cycles following exercise and consumption of meals. The aim of this study was to explore the pharmacokinetics of H. perforatum phytochemicals after ingestion to predict the absorption timing of putative medicinal phytochemicals.In silico analyses of previously published plant extract phytochemical profiles were performed, wherein the Phytochemical Absorption Prediction (PCAP) model was used to predict the pharmacokinetics of phytochemicals. The predicted times for phytochemicals to reach maximum plasma concentration (Tmax), and associated antioxidant activities, were compared to prior clinical in vivo studies to assess the accuracy and applicability of predictions.The PCAP model identified that phytochemicals with antioxidant activity concurrently accumulate in plasma with Tmax in the range of 1.6-2.3 h after ingestion. Comparison with previously published results identified that attenuation of OSI following H. perforatum ingestion aligns with the predicted Tmax of antioxidant phytochemicals.Based on these results it is therefore recommended that H. perforatum administration occurs 2 h before meals to provide optimal secondary health benefits associated with inhibition of postprandial stress. Additionally, these results highlight the use of in silico analyses to inform ingestion time and optimize the health benefits from ingestion of plant-based foods and medicines." @default.
• W2900936706 created "2018-11-29" @default.
• W2900936706 creator A5039269607 @default.
• W2900936706 creator A5059817442 @default.
• W2900936706 creator A5086164069 @default.
• W2900936706 creator A5086470484 @default.
• W2900936706 date "2019-06-01" @default.
• W2900936706 modified "2023-09-27" @default.
• W2900936706 title "Pharmacokinetic properties of phytochemicals in Hypericum perforatum influence efficacy of regulating oxidative stress" @default.
• W2900936706 cites W174715135 @default.
• W2900936706 cites W1879559146 @default.
• W2900936706 cites W1963876824 @default.
• W2900936706 cites W1973207984 @default.
• W2900936706 cites W1978840408 @default.
• W2900936706 cites W1978871608 @default.
• W2900936706 cites W1982444921 @default.
• W2900936706 cites W1985734864 @default.
• W2900936706 cites W1990696669 @default.
• W2900936706 cites W1990771160 @default.
• W2900936706 cites W1997881702 @default.
• W2900936706 cites W2005747983 @default.
• W2900936706 cites W2024166669 @default.
• W2900936706 cites W2031971602 @default.
• W2900936706 cites W2038266887 @default.
• W2900936706 cites W2039749761 @default.
• W2900936706 cites W2040422172 @default.
• W2900936706 cites W2043563630 @default.
• W2900936706 cites W2044474173 @default.
• W2900936706 cites W2046582216 @default.
• W2900936706 cites W2051328183 @default.
• W2900936706 cites W2053287250 @default.
• W2900936706 cites W2053310956 @default.
• W2900936706 cites W2054506548 @default.
• W2900936706 cites W2056510708 @default.
• W2900936706 cites W2059029852 @default.
• W2900936706 cites W2064594610 @default.
• W2900936706 cites W2068080536 @default.
• W2900936706 cites W2072141425 @default.
• W2900936706 cites W2074137202 @default.
• W2900936706 cites W2076006785 @default.
• W2900936706 cites W2078317560 @default.
• W2900936706 cites W2081187091 @default.
• W2900936706 cites W2083840820 @default.
• W2900936706 cites W2086959952 @default.
• W2900936706 cites W2089220405 @default.
• W2900936706 cites W2091685154 @default.
• W2900936706 cites W2108685524 @default.
• W2900936706 cites W2124441017 @default.
• W2900936706 cites W2127550132 @default.
• W2900936706 cites W2144843569 @default.
• W2900936706 cites W2153394357 @default.
• W2900936706 cites W2154745788 @default.
• W2900936706 cites W2163490578 @default.
• W2900936706 cites W2170258455 @default.
• W2900936706 cites W2312452216 @default.
• W2900936706 cites W2414089395 @default.
• W2900936706 cites W2529013547 @default.
• W2900936706 cites W2613154581 @default.
• W2900936706 cites W2730345332 @default.
• W2900936706 cites W2762627153 @default.
• W2900936706 cites W2765866238 @default.
• W2900936706 cites W2768841553 @default.
• W2900936706 cites W2779336640 @default.
• W2900936706 cites W2792695057 @default.
• W2900936706 cites W2799948602 @default.
• W2900936706 cites W2803948958 @default.
• W2900936706 cites W4239169228 @default.
• W2900936706 cites W2773964750 @default.
• W2900936706 doi "https://doi.org/10.1016/j.phymed.2018.11.023" @default.
• W2900936706 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31004882" @default.
• W2900936706 hasPublicationYear "2019" @default.
• W2900936706 type Work @default.
• W2900936706 sameAs 2900936706 @default.
• W2900936706 citedByCount "8" @default.
• W2900936706 countsByYear W29009367062020 @default.
• W2900936706 countsByYear W29009367062021 @default.
• W2900936706 countsByYear W29009367062022 @default.
• W2900936706 countsByYear W29009367062023 @default.
• W2900936706 crossrefType "journal-article" @default.
• W2900936706 hasAuthorship W2900936706A5039269607 @default.
• W2900936706 hasAuthorship W2900936706A5059817442 @default.
• W2900936706 hasAuthorship W2900936706A5086164069 @default.
• W2900936706 hasAuthorship W2900936706A5086470484 @default.
• W2900936706 hasConcept C112705442 @default.
• W2900936706 hasConcept C126322002 @default.
• W2900936706 hasConcept C185592680 @default.
• W2900936706 hasConcept C193230392 @default.
• W2900936706 hasConcept C195475562 @default.
• W2900936706 hasConcept C2776151105 @default.
• W2900936706 hasConcept C2776651039 @default.
• W2900936706 hasConcept C2778004101 @default.
• W2900936706 hasConcept C55493867 @default.
• W2900936706 hasConcept C556039675 @default.
• W2900936706 hasConcept C71924100 @default.
• W2900936706 hasConcept C98274493 @default.
• W2900936706 hasConceptScore W2900936706C112705442 @default.
• W2900936706 hasConceptScore W2900936706C126322002 @default.
• W2900936706 hasConceptScore W2900936706C185592680 @default.

• next