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• W2900962811 abstract "In traditional medicine, guduchi (Tinospora cordifolia) is considered as an adaptogen with immunomodulatory prowess. A 25 kDa protein from guduchi stem has been characterized as an immunomodulatory protein (ImP). The aim of this study was to evaluate the intrinsic immunogenicity of guduchi ImP and adjuvant activity using ovalbumin (OVA) as antigen in BALB/c mice. Mice were given guduchi ImP (30 and 60 μg) by intranasal administration to respective groups (n = 6) on days 1, 14 and thereafter weekly till day 42. Immunogenic response was monitored by serum IgG/IgA levels (days 14, 35 and 50). The adjuvant activity was measured by serum anti-OVA IgG/IgA responses to administration of 30 μg OVA with guduchi ImP. The effect of guduchi ImP on the spleen status was examined by splenic weight (day 50). Guduchi ImP administration displayed a significant increase in anti-guduchi ImP IgG (5–7 fold) and anti-guduchi ImP IgA (3–4 fold) on day 50 vs. control. Guduchi ImP showed a significant increase in anti-OVA IgG (6–7 fold) and anti-OVA IgA (4–5 fold) on day 50 vs. control. The splenic index of guduchi ImP group increased significantly in both the immune and adjuvant response groups; however, the splenic index in the adjuvant response group was markedly higher. The results indicate that guduchi ImP is a strong immunogen by itself and enhances the immunogenicity of mucosally-administered antigen in BALB/c mice. Based on the results of this animal study, it appears that guduchi ImP shows a potential for future studies in humans." @default.
• W2900962811 created "2018-11-29" @default.
• W2900962811 creator A5081515669 @default.
• W2900962811 creator A5086508852 @default.
• W2900962811 date "2020-04-01" @default.
• W2900962811 modified "2023-09-27" @default.
• W2900962811 title "Humoral immune and adjuvant responses of mucosally-administered Tinospora cordifolia immunomodulatory protein in BALB/c mice" @default.
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• W2900962811 doi "https://doi.org/10.1016/j.jaim.2017.10.006" @default.
• W2900962811 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7329723" @default.
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• W2900962811 hasPublicationYear "2020" @default.
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