Matches in SemOpenAlex for { <https://semopenalex.org/work/W2900979774> ?p ?o ?g. }
- W2900979774 endingPage "331" @default.
- W2900979774 startingPage "321" @default.
- W2900979774 abstract "Inner and outer blood-retinal barriers (BRBs), mainly composed of retinal endothelial cells and retinal pigment epithelial (RPE) cells, respectively, maintain the integrity of the retinal tissues. In this study, we aimed to investigate the mechanisms of the outer BRB disruption regarding the interaction between RPE and microglia. In mice with high-fat diet-induced obesity and streptozotocin-induced hyperglycemia, microglia accumulated on the RPE layer, as in those after intravitreal injection of interleukin (IL)-6, which is elevated in ocular fluids of patients with diabetic retinopathy. Although IL-6 did not directly affect the levels of zonula occludens (ZO)-1 and occludin in RPE cells, IL-6 increased VEGFA mRNA in RPE cells to recruit microglial cells. In microglial cells, IL-6 upregulated the mRNA levels of MCP1, MIP1A, and MIP1B, to amplify the recruitment of microglial cells. In this manner, IL-6 modulated RPE and microglial cells to attract microglial cells on RPE cells. Furthermore, IL-6-treated microglial cells produced and secreted tumor necrosis factor (TNF)-α, which activated NF-κB and decreased the levels of ZO-1 in RPE cells. As STAT3 inhibition reversed the effects of IL-6-treated microglial cells on the RPE monolayer in vitro, it reduced the recruitment of microglial cells and the production of TNF-α in RPE tissues in streptozotocin-treated mice. Taken together, IL-6-treated RPE and microglial cells amplified the recruitment of microglial cells and IL-6-treated microglial cells produced TNF-α to disrupt the outer BRB in diabetic retinopathy." @default.
- W2900979774 created "2018-11-29" @default.
- W2900979774 creator A5018933458 @default.
- W2900979774 creator A5022974146 @default.
- W2900979774 creator A5035016379 @default.
- W2900979774 creator A5040142944 @default.
- W2900979774 creator A5089754599 @default.
- W2900979774 creator A5090333957 @default.
- W2900979774 date "2018-11-16" @default.
- W2900979774 modified "2023-10-17" @default.
- W2900979774 title "Interaction between microglia and retinal pigment epithelial cells determines the integrity of outer blood-retinal barrier in diabetic retinopathy" @default.
- W2900979774 cites W1267894645 @default.
- W2900979774 cites W1484398243 @default.
- W2900979774 cites W1583152018 @default.
- W2900979774 cites W1969597610 @default.
- W2900979774 cites W1972296893 @default.
- W2900979774 cites W1979814725 @default.
- W2900979774 cites W1992910123 @default.
- W2900979774 cites W2000919900 @default.
- W2900979774 cites W2004349171 @default.
- W2900979774 cites W2012903920 @default.
- W2900979774 cites W2043145415 @default.
- W2900979774 cites W2053270619 @default.
- W2900979774 cites W2053588089 @default.
- W2900979774 cites W2060842460 @default.
- W2900979774 cites W2067514922 @default.
- W2900979774 cites W2089853352 @default.
- W2900979774 cites W2090649564 @default.
- W2900979774 cites W2104617137 @default.
- W2900979774 cites W2121919167 @default.
- W2900979774 cites W2147457499 @default.
- W2900979774 cites W2153127461 @default.
- W2900979774 cites W2160870679 @default.
- W2900979774 cites W2161818169 @default.
- W2900979774 cites W238288757 @default.
- W2900979774 cites W2463461993 @default.
- W2900979774 cites W2514622389 @default.
- W2900979774 cites W2581144175 @default.
- W2900979774 cites W2602883505 @default.
- W2900979774 cites W2729371721 @default.
- W2900979774 cites W2757271110 @default.
- W2900979774 cites W2769071992 @default.
- W2900979774 cites W2788797941 @default.
- W2900979774 doi "https://doi.org/10.1002/glia.23542" @default.
- W2900979774 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30444022" @default.
- W2900979774 hasPublicationYear "2018" @default.
- W2900979774 type Work @default.
- W2900979774 sameAs 2900979774 @default.
- W2900979774 citedByCount "77" @default.
- W2900979774 countsByYear W29009797742019 @default.
- W2900979774 countsByYear W29009797742020 @default.
- W2900979774 countsByYear W29009797742021 @default.
- W2900979774 countsByYear W29009797742022 @default.
- W2900979774 countsByYear W29009797742023 @default.
- W2900979774 crossrefType "journal-article" @default.
- W2900979774 hasAuthorship W2900979774A5018933458 @default.
- W2900979774 hasAuthorship W2900979774A5022974146 @default.
- W2900979774 hasAuthorship W2900979774A5035016379 @default.
- W2900979774 hasAuthorship W2900979774A5040142944 @default.
- W2900979774 hasAuthorship W2900979774A5089754599 @default.
- W2900979774 hasAuthorship W2900979774A5090333957 @default.
- W2900979774 hasConcept C134018914 @default.
- W2900979774 hasConcept C169760540 @default.
- W2900979774 hasConcept C177779419 @default.
- W2900979774 hasConcept C17991360 @default.
- W2900979774 hasConcept C201750760 @default.
- W2900979774 hasConcept C203014093 @default.
- W2900979774 hasConcept C2775962179 @default.
- W2900979774 hasConcept C2776914184 @default.
- W2900979774 hasConcept C2777093970 @default.
- W2900979774 hasConcept C2777102633 @default.
- W2900979774 hasConcept C2778024200 @default.
- W2900979774 hasConcept C2778371105 @default.
- W2900979774 hasConcept C2779280383 @default.
- W2900979774 hasConcept C2779829184 @default.
- W2900979774 hasConcept C2779830541 @default.
- W2900979774 hasConcept C2780827179 @default.
- W2900979774 hasConcept C2780884517 @default.
- W2900979774 hasConcept C28328180 @default.
- W2900979774 hasConcept C529278444 @default.
- W2900979774 hasConcept C55493867 @default.
- W2900979774 hasConcept C555293320 @default.
- W2900979774 hasConcept C86803240 @default.
- W2900979774 hasConcept C95444343 @default.
- W2900979774 hasConceptScore W2900979774C134018914 @default.
- W2900979774 hasConceptScore W2900979774C169760540 @default.
- W2900979774 hasConceptScore W2900979774C177779419 @default.
- W2900979774 hasConceptScore W2900979774C17991360 @default.
- W2900979774 hasConceptScore W2900979774C201750760 @default.
- W2900979774 hasConceptScore W2900979774C203014093 @default.
- W2900979774 hasConceptScore W2900979774C2775962179 @default.
- W2900979774 hasConceptScore W2900979774C2776914184 @default.
- W2900979774 hasConceptScore W2900979774C2777093970 @default.
- W2900979774 hasConceptScore W2900979774C2777102633 @default.
- W2900979774 hasConceptScore W2900979774C2778024200 @default.
- W2900979774 hasConceptScore W2900979774C2778371105 @default.
- W2900979774 hasConceptScore W2900979774C2779280383 @default.
- W2900979774 hasConceptScore W2900979774C2779829184 @default.