FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2900992342> ?p ?o ?g. }

• W2900992342 abstract "Non-small cell lung cancer (NSCLC) is a major type of human lung cancer and the primary cause of cancer-associated cases of mortality worldwide. Phosphatase and tensin homolog (PTEN) is a potent tumor suppressor gene in various human cancer types. The aim of the current study was to explore the role of PTEN and its associated regulatory mechanisms in NSCLC. Firstly, the expression of PTEN was detected using western blotting in a variety of NSCLC cell lines. The results revealed that compared with normal control cells, PTEN levels were significantly decreased in NSCLC cell lines (P<0.01). Short hairpin (sh)RNAs specific to PTEN were also used to knockdown endogenous PTEN in NSCLC cells. The results indicated that cell viability was significantly increased in PTEN-knockdown cells compared with those transfected with negative control shRNA (P<0.01). Conversely, overexpression of PTEN in A549 and SK-MES-1 cells significantly decreased the optical density of NSCLC cells (P<0.01). Flow cytometry was used to investigate the cell cycle; the results revealed that PTEN knockdown significantly increased the percentage of cells at G0/G1 phase (P<0.01) and decreased the number of cells at S phase (P<0.01). The molecular mechanism was further explored using western blotting and the results demonstrated that PTEN overexpression increased the levels of cleaved caspase-3 (P<0.01). These results suggest that PTEN may be a potential target gene for gene therapy in patients with NSCLCs." @default.
• W2900992342 created "2018-11-29" @default.
• W2900992342 creator A5024061277 @default.
• W2900992342 creator A5028303506 @default.
• W2900992342 creator A5032285655 @default.
• W2900992342 creator A5057236160 @default.
• W2900992342 creator A5078874118 @default.
• W2900992342 creator A5083019914 @default.
• W2900992342 creator A5087458403 @default.
• W2900992342 date "2018-11-16" @default.
• W2900992342 modified "2023-09-29" @default.
• W2900992342 title "PTEN inhibits non‑small cell lung cancer cell growth by promoting G0/G1 arrest and cell apoptosis" @default.
• W2900992342 cites W1900250971 @default.
• W2900992342 cites W1966446241 @default.
• W2900992342 cites W1981748118 @default.
• W2900992342 cites W1983906597 @default.
• W2900992342 cites W2014554544 @default.
• W2900992342 cites W2016664476 @default.
• W2900992342 cites W2050373746 @default.
• W2900992342 cites W2052089977 @default.
• W2900992342 cites W2054914387 @default.
• W2900992342 cites W2056067341 @default.
• W2900992342 cites W2058421409 @default.
• W2900992342 cites W2080595478 @default.
• W2900992342 cites W2099295163 @default.
• W2900992342 cites W2153360462 @default.
• W2900992342 cites W2157449758 @default.
• W2900992342 cites W2158253569 @default.
• W2900992342 cites W2161810908 @default.
• W2900992342 cites W2167122790 @default.
• W2900992342 cites W2286288823 @default.
• W2900992342 cites W2316248694 @default.
• W2900992342 cites W2325332043 @default.
• W2900992342 cites W2385742736 @default.
• W2900992342 cites W2406766989 @default.
• W2900992342 cites W2408897964 @default.
• W2900992342 cites W2410977756 @default.
• W2900992342 cites W2429907263 @default.
• W2900992342 cites W2461804848 @default.
• W2900992342 cites W2471681253 @default.
• W2900992342 cites W2478684609 @default.
• W2900992342 cites W2497971855 @default.
• W2900992342 cites W2498826978 @default.
• W2900992342 cites W2531150801 @default.
• W2900992342 cites W2543795704 @default.
• W2900992342 cites W2595235288 @default.
• W2900992342 cites W2598228252 @default.
• W2900992342 doi "https://doi.org/10.3892/ol.2018.9719" @default.
• W2900992342 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6313010" @default.
• W2900992342 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30655903" @default.
• W2900992342 hasPublicationYear "2018" @default.
• W2900992342 type Work @default.
• W2900992342 sameAs 2900992342 @default.
• W2900992342 citedByCount "10" @default.
• W2900992342 countsByYear W29009923422020 @default.
• W2900992342 countsByYear W29009923422021 @default.
• W2900992342 countsByYear W29009923422022 @default.
• W2900992342 crossrefType "journal-article" @default.
• W2900992342 hasAuthorship W2900992342A5024061277 @default.
• W2900992342 hasAuthorship W2900992342A5028303506 @default.
• W2900992342 hasAuthorship W2900992342A5032285655 @default.
• W2900992342 hasAuthorship W2900992342A5057236160 @default.
• W2900992342 hasAuthorship W2900992342A5078874118 @default.
• W2900992342 hasAuthorship W2900992342A5083019914 @default.
• W2900992342 hasAuthorship W2900992342A5087458403 @default.
• W2900992342 hasBestOaLocation W29009923421 @default.
• W2900992342 hasConcept C121608353 @default.
• W2900992342 hasConcept C126322002 @default.
• W2900992342 hasConcept C1491633281 @default.
• W2900992342 hasConcept C173396325 @default.
• W2900992342 hasConcept C190232843 @default.
• W2900992342 hasConcept C190283241 @default.
• W2900992342 hasConcept C2776256026 @default.
• W2900992342 hasConcept C2777609662 @default.
• W2900992342 hasConcept C2778264664 @default.
• W2900992342 hasConcept C2779549131 @default.
• W2900992342 hasConcept C2781018059 @default.
• W2900992342 hasConcept C29537977 @default.
• W2900992342 hasConcept C502942594 @default.
• W2900992342 hasConcept C54355233 @default.
• W2900992342 hasConcept C555283112 @default.
• W2900992342 hasConcept C62112901 @default.
• W2900992342 hasConcept C71924100 @default.
• W2900992342 hasConcept C81729549 @default.
• W2900992342 hasConcept C86554907 @default.
• W2900992342 hasConcept C86803240 @default.
• W2900992342 hasConceptScore W2900992342C121608353 @default.
• W2900992342 hasConceptScore W2900992342C126322002 @default.
• W2900992342 hasConceptScore W2900992342C1491633281 @default.
• W2900992342 hasConceptScore W2900992342C173396325 @default.
• W2900992342 hasConceptScore W2900992342C190232843 @default.
• W2900992342 hasConceptScore W2900992342C190283241 @default.
• W2900992342 hasConceptScore W2900992342C2776256026 @default.
• W2900992342 hasConceptScore W2900992342C2777609662 @default.
• W2900992342 hasConceptScore W2900992342C2778264664 @default.
• W2900992342 hasConceptScore W2900992342C2779549131 @default.
• W2900992342 hasConceptScore W2900992342C2781018059 @default.
• W2900992342 hasConceptScore W2900992342C29537977 @default.
• W2900992342 hasConceptScore W2900992342C502942594 @default.
• W2900992342 hasConceptScore W2900992342C54355233 @default.

• next